You’ll Never Worry About Cholesterol After This
Hello Health Champions. Cholesterol and heart attacks are perhaps the most
misunderstood topic in all of healthcare and as a result a lot of people get hurt and are suffering
needlessly. And here are just some of the problems we hear forever that HDL is good LDL is bad. High
cholesterol is bad and that's just way way too simplistic. There's so much more to it than that
we hear that a statin drug could be necessary after we try diet and exercise without success
but the question is what diet and what exercise are they trying and very often people ask me or
I see suggestions of natural remedies to lower cholesterol but the question is are we sure we
want to lower it now please keep in mind that I am not saying that a stat drug is never a good idea
I'm not saying that cholesterol can never be too high or out of balance that's not what I'm saying
but there may be like one percent of people with a genetic defect with familial hypercholesterolemia
whereas that drug is the right thing for them but for the vast majority of people who get
blanket recommendations of statin drugs because their cholesterol is too high
we need to understand a lot more and even though I will defend higher cholesterol numbers I'm not
saying that higher is always better and I'm not saying that you should not get concerned about
what your blood work says that you should just disregard everything on there what I am saying
is I think it's a bad idea to make a diagnosis on a single marker such as high cholesterol
or high LDL and if we then based on that diagnosis get a prescription for a chemical or medication
that will interfere with the function of the liver which we'll talk about
and interfere with health then I believe we are doing some of the greatest disservices
to mankind and we need to understand some of the things that I'm going to talk about
first we need to understand something about this molecule cholesterol first of all it's synthesized
in every cell of your body that has a nucleus that's basically every cell except red blood
cells can make cholesterol a lot of it is made in the liver and that's traditionally where we hear
that cholesterol is made and because the body makes cholesterol itself then if you eat less then
the body will make more if you eat more the body will make less the body needs to have a certain
amount of cholesterol and the brain is one of the places that's most dependent on cholesterol 23%
of all the cholesterol in your body is in the brain and interestingly
the cholesterol molecule is too large to cross the blood-brain barrier so all of the cholesterol in
the brain is manufactured in the brain because it's that important cholesterol is necessary
for many things and one of the most important is as a building material as a structural component
the cell membrane which is the surface bilayer of every cell in your body
30 mole percent meaning 30% of the number of molecules in that cell membrane
is cholesterol and if you look at these little arrows this yellow structure is cholesterol so 30%
is a lot more than what they're showing in this picture 30% of your cell membrane is cholesterol
and why is that cell membrane so important because the cell membrane is the actual decision maker of
everything in your body your body processes billions of bits of information every second
and it's all about the cell membrane because the cell membrane is a barrier that determines
what stays outside and what gets into the cell and inside the cell is where you have your metabolism
and your metabolic function and the manufacture of every hormone and protein and substance
in your body and cholesterol is a huge part of determining the properties of this cell
membrane because there's a fine balance between rigidity and flexibility when you determine
how the cell membrane works so cholesterol is critical for the function of that cell membrane
and where do you have the most important cell membranes that handle the most signals well in
the brain of course which has tons of cholesterol and then when the brain needs to send the messages
out to the periphery when the central nervous system talks to the peripheral nervous system
which has millions of these electrical wires that go to every little part of your body then it sends
it along a nerve pathway called an axon and this axon it's just like electrical wires in your house
basically that it needs a surface insulation just like your wires have that plastic coating so does
your axons and your nerves need an insulation and that insulation is called myelin that myelin is 27
cholesterol and there is a severe disease called multiple sclerosis which happens when this myelin
is defective or gets attacked cholesterol is also a precursor to bile so when your gallbladder
releases bile to dissolve fats to help you digest fats bile consists mostly of cholesterol
it's also a precursor to steroid hormones so a lot of your endocrine system a very fine-tuned
communication system depends on cholesterol so testosterone estrogen and progesterone are made
from cholesterol and also cortisol and very often I talk about cortisol in this channel because
cortisol is a stress hormone and too much of it on a chronic basis contributes to a lot of health
problems but it doesn't mean that we don't need it it's still critical because if you can't have
a stress response then you're basically a sitting duck that means you can't respond to the events
of life and you might just be standing there when the bus comes to run you over
so with all these functions of cholesterol do we really want to just shut it down do we really just
unilaterally say that cholesterol is a bad thing you have too much let's shut it down there's no
wonder that there's such dramatic side effects when we try to interfere with cholesterol and what
about ldl and HDL we've heard that their LDL is bad HDL is good but they are just doing their job
ldl is a low density lipoprotein it's a carrier that contains a little bit more cholesterol
than the HDL does and therefore its job is to deliver cholesterol when the body needs it when
appropriate the HDL is high density lipoprotein so it has a lower percentage of cholesterol
so therefore it tends to attract it collects and returns cholesterol so if the body has to have
LDL or cholesterol delivered then it would seem like a really good thing
to have some LDL to deliver that right and if the body needs HDL to collect then that would seem
like a really good thing the appropriate amount of LDL and the appropriate amount of HDL is a
good thing it's not that LDL or HDL is good or bad what we want to be concerned with
is the properties the state the health of these particles and what we want to watch is small LDL
when the LDL is large and fluffy there's nothing wrong with it there are no ill health effects
but when it gets small it is because it's damaged by inflammation and by oxidative stress
and we'll talk a lot about this so you get it totally clear so the small LDL also it is a bad
thing in a sense that it indicates that something is wrong but the small LDL itself is just a victim
of inflammation and oxidative stress and what is the cause of inflammation and oxidative stress
it is sugar toxins and excess free radicals and that excess is key to understand that
oxidative stress is necessary to produce energy free radicals is necessary
as a result of producing energy and performing metabolism but when things get out of balance
and we have all these things in excess that's when we have a problem and I've used this
analogy before but I really want to reinforce this that we want to stop calling LDL bad because LDL
shows up after the problem when we have oxidative stress LDL is delivered to repair the damage
it's like we see the fire department at the scene of an accident and we say oh that evil
fire department is there causing accidents again no they showed up after and they're trying to help
the victim because the victim indicates that something bad happened but LDL and HDL are both
good things just like these first responders are and when the blood work comes back with a
cholesterol over 200 then it's almost a knee-jerk response for a lot of practitioners to recommend
a statin drug so what do statins do there are a couple of things we'll talk about but one of the
things that's really important to understand is it can upregulate the number of LDL receptors on the
liver so the liver recycles these LDL particles and on the surface of an LDL particle there is
something called an apo b protein that can be recognized by these receptors and then the liver
recycles these LDL's so the statin drug increases the number of receptors and now we can start
recycling these LDL's but here's the thing it is only the large and the fluffy the buoyant LDL
that's healthy that get recycled right so we reduce the total number of cholesterol
of LDL cholesterol by reducing the fluffy buoyant LDL but it is the oxidized damaged LDL that we're
trying to get rid of and this has a damaged Apo-B protein so the receptor can't recognize it see no
matter how much we up regulate the receptors there is no change to these oxidized LDL'
so we could make an argument that we're still doing a good job because if we reabsorb more
of the fluffy LDL then there will be less LDL overall in total to get oxidized in the future but
what really happens that's more important is that we change the ratio and we'll talk more about that
that we the ratio of the oxidized to the buoyant the small to the large LDL that ratio goes up
and gets much much worse and this is one of the more important indicators for heart disease
so even though the statin drug will reduce the total number it will make the ratio worse the
small LDL does damage in many ways first of all it's an indicator of damage because if we have
a lot of small LDL we know that there's a lot of oxidative stress and inflammation but furthermore
this inflammation and oxidative stress it can create damage or cracks in the inside surface and
the intima of the blood vessel and if you notice that this plaque here is not inside the opening
it's not inside the lumen of the blood vessel it is between the surface layer and the muscular wall
so the surface layer the inside has to crack it has to get more loose so that these particles can
get through and create these plaques and the small particles will slip through the cracks
much much easier the large fluffy ones don't tend to do that and the other problem like we talked
about is the small LDL cannot be recognized by the receptors so when we have a buildup of these
and they slip through then we need for someone else to take care of them and this is where the
immune system comes in you have white blood cells called macrophages they're like little Pac mans
and they follow these small particles in through the cracks or wherever these small LDL's are but
if they've gone through these cracks behind the intima now that's where they hang out and that's
where the immune cells go and now they gobble up as many of these little LDL's as they can and then
when they're full now they've contained the LDL's but they've turned into foam cells and that is
basically what the plaque is but now let's look at some actual blood work to help us understand
what we need to look for to understand the bigger picture we don't want to make a diagnosis we don't
want to hyper focus on one variable we want to understand the bigger picture what are
all of the markers or some of the markers involved with insulin resistance metabolic syndrome
poor metabolic health inflammation stress etc. here is a patient that came in first to me around
September and we did some blood work and then we repeated the blood work after about three months
almost exactly three months first thing we look at I've condensed this we're just looking at a few
variables here but glucose according to the reference needs to be 65.99 and I think
the 99 is too high I think it needs to be under 88, 85 ish 65 is fine if you're on a low carb
diet otherwise it probably indicates hypoglycemia but this guy had really good glucose control even
when he came in at 82 after a few months it was 74 so both of those values are good no big deal
then we look at some liver enzymes the AST is often called the liver enzyme but it is
part of several different organs and these enzymes are not really supposed to be
in the blood they end up in the blood when the cells wear out and they spill their content
and some of that is normal because we have a turnover of cells so if a few cells break
and spill their enzymes that's okay and the range for this one is 0 to 40 and
it's never going to be zero but 40 is really too high you want it kind of to be 25 or so
and he started out at 29 but after three months he was at 20. so we see some improvement
the alt is also not a hundred percent specific for liver but it's mostly specific to liver
and that one they put at zero to forty four he started out at forty again a little bit too high
after three months he's in a much better range 27. then we look at total cholesterol and they want to
see that 100 to 199 in my mind a completely crazy arbitrary number if it is under 150 i will be
much much more concerned than if it's 300 because cholesterol is necessary and if it gets too low
then that means your liver is not healthy enough to make it could be something like heavy metal
toxicity so anyway this person had 277 and this is by the way it's a 43 year old male and then after
three months it is one point worse so basically no difference we look at triglycerides which is the
fat in the blood so traditionally we hear that if you eat a high fat diet your fat in the blood will
go up and they want to see that 0 to 149 if it's zero you'll be dead if it's 149 I think that's too
high I want to see that probably between 50 to 80. and he started out at 112 after three months it
was 65. VLDL is also a great indicator of insulin resistance just like triglycerides are because the
VLDL is a very large very low density lipoprotein it has even more triglycerides in it than the LDL
so its job is to deliver the triglycerides into circulation and if your cells are resistant and
it doesn't accept and and let that triglyceride in for fuel because it already has too much fuel that
cell is resistant and the triglycerides will build up and if the cells don't want the triglycerides
the VLDL has nobody to deliver to so therefore the triglycerides and the VLDL both go up with
insulin resistance the lab range for VLDL is 5 to 40 and I never want to see 40 because that is
strongly pre-diabetic this guy came in at 20 which is pretty good but still a little bit too high I'd
rather see it under 17, 18 or under 15. but after three months he is at ten which is a very healthy
number so he had some insulin resistance starting out even though he had good glucose control
at 82 he was still a little bit insulin resistance based on the triglycerides and the VLDL but after
three months it's looking much better then we look at the LDL-C which is calculated LDL or the
milligrams or the mass of LDL it doesn't count the particles which we'll get to in a second
and this number they want to see under 99 again the range is 0 to 99 and it's zero you'll be dead
so I don't know why the range goes to zero but 99 again is a totally arbitrary number because it's
about the health of the LDL particles not the total amount and my patient started out at 209
so more than double what he was supposed to have and after three months he had 215 so basically
no change or even a little bit worse and the only thing that shows up on these blood reports
is the high flag for total cholesterol and LDL so in their minds this guy is a perfect candidate
for statin medications but if we're starting to understand the bigger picture and we look
at all these markers that have to do with the true risk markers for heart disease we see that
glucose got better AST, ALT enzymes got better and triglycerides and VLDL got better so he had
five out of seven markers that got dramatically better while two of these stayed the same so to
me this is saying this person is getting healthier and this is the level of cholesterol that his body
likes to have now so far all these numbers you could get on a very standard blood work
but if we want to start understanding a little bit more we add something called an NMR profile
where we can start looking at the size and the number of particles so when we look at the LDL
particle number then the range is supposed to be under a thousand and my patients started out
at two thousand seven hundred so almost three times higher number of LDL particle that looks
like a disaster right but we don't want to jump to conclusions because we see a lot of the other
markers are actually getting better so we want to know what's happening here and one of the things
we want to analyze this is we want to understand what does this mean what is the significance
of these different numbers and when we look at the number of small LDL's they want to see less
than 527 out of a thousand in the mainstream criteria that means they think it's okay if you
have up to 53 percent of all your LDL be small and damaged and why do I construct that number
and look at it because that represents the degree of inflammation and oxidative stress in the system
if you have a thousand LDL particles on average 53 of those are going to get damaged and to me
that is way too high I don't care about the total number as much as I do the percentage
that get damaged so my patient here started out at 1400 three months earlier so he was at 52
again I'm not happy with that at all but even though he has a lot of LDL particles he is no
worse than the mainstream criteria for acceptable but again I want to see that much lower and what
we see then is after three months even though his total cholesterol basically stayed the same
and his LDL went up his particle number went down by over 300. and when we look at the nitty gritty
and we look at the small LDL particles this is nothing short of amazing he went from 1400 to 200
small particles he did away with 85 percent of his particles and he went from 52 percent to 9
again why is this so huge because the 52 percent represents how many percent
get damaged by oxidation and inflammation and if we can go from 52 percent to 9 percent we
have massively reduced his risk of heart disease so what do we do with this we follow up again in
three months and now we see that we have one two three four five six seven out of nine markers are
vastly improved so we check again in three months and we see make sure that we're still going in the
right direction but we don't jump to conclusions based on a single number now let's understand a
little bit more about the mechanisms of statin drugs because anytime you have high cholesterol
they want to prescribe a statin so we want to understand what's actually happening in the
body so does a statin drug medication reduce the total amount of cholesterol yes absolutely it does
and one way is that it up regulates the receptors we get more of the recycling but
it does not reduce the small LDL so even though it reduces the total and the LDL it doesn't reduce
the kind that we try to get rid of so I just want to emphasize that over and over it's so critical
but the main way that the statin does its work is through something called the mevalonate pathway
and here's how that works when the body makes cholesterol it starts out with the substance
called HMG-CoA reductase and then through a number of different steps that I don't bother
with the details in the end the body ends up with cholesterol so the names here are not important
I just want you to show that there's a number of different steps and we end up with cholesterol but
once we take a statin once we take a medication to lower cholesterol and to block the production then
we knock out a lot of this HMG-CoA reductase and when we do that of course we also knock out the
end result of that pathway which is cholesterol but there's one more detail and that is
there's another product from a component halfway down called CoQ10 and the CoQ10 also gets knocked
out to a large degree to probably whatever percentage we reduce cholesterol by we're
also going to reduce CoQ10 because they're part of the same pathway and what does CoQ10 do it
is one of the enzymes that the mitochondria use to produce energy so 95% of our energy of
all the energy used by every cell in your body depends on CoQ10 so any time that you block the
production of CoQ10 you're also blocking some of the production of energy so if you have to be
on a cholesterol medication for whatever reason or if you're working to get healthy so you could
have that discussion with your doctor at the very least you want to make sure that you supplement
quite massively with CoQ10 probably at least 300 milligrams a day and cholesterol medication are
very controversial because they have a much higher rate of side effects than just about anything else
out there and here are some of those SAMS stands for statin associated symptoms
and in increasing severity it starts with myalgia which is muscle pain then we have muscle disease
we have myositis which is muscle inflammation now the disease is so bad that we start breaking some
cells and they spill an enzyme called creatinine kinase so now it means the muscles are breaking
down more than they should and the worst version of this is called rhabdomyolysis and
"rhabdo" means striated or skeletal muscle "myo" means muscle and "lysis" means it's basically
melting that your muscles are just disintegrating this is completely disabling and sometimes fatal
part of this picture is also joint inflammation tendon disorders arthritis and things like that
because joints get 90 percent of their stability support from muscles so if the
muscles don't work and they're not firing right then the joints are going to get unstable and
suffer and get inflamed as well statins have also been associated with type 2 diabetes
with neurological problems with neurocognitive effects and cognitive you want to think
focus memory intelligence things like that also hemorrhagic stroke bleeding stroke bleeding in
the brain hepatotoxicity that you're interfering so much with the liver that the liver gets toxic
and the kidneys can also get toxic and there's many more conditions so lots of side effects are
observed but they keep saying that they're unclear about the mechanism but we do know
that it interferes with the production of coq10 so we will have a loss of energy so whatever body
parts whatever organs use the most energy are probably going to be the ones to suffer the most
and those would be the brain the heart the liver and the muscles because they are higher
metabolically active than most other tissues and other than that cholesterol medications are so
beneficial because after all they lower cholesterol right but I hope you see by now that
just looking at one number and saying we need to lower cholesterol in itself is not the goal
here's something that will hopefully get your attention in a study they found that lipophilic
statins which is a subclass a type most common class of statin drugs more than doubles the risk
of dementia one of the most devastating conditions one of the things that people are the most afraid
of is to lose their whole personality and their cognition these medications can more than double
and this was from the society of nuclear medicine and molecular imaging in 2021 annual meeting
so they did some pet scans which is sophisticated brain imaging and they found a substantial
decline in metabolism substantial decline in energy production and activity
in the posterior cingulate cortex that is the first place to lose function to have decreased
function when people have early Alzheimer's here's another study from neurology 2005 and they found
that when we look at the risk of dementia there was a longitudinal study they followed people for
many many years as they were aging and at 70 years old they looked at the people with the overall
lowest cholesterol not because they were taking a medication or anything they just looked at
what are their cholesterol levels and they compared the lowest group to the highest group and
they found that there was 69 percent less dementia in the people with the highest cholesterol
they followed this along and when these people were 76 years old they found that there was 80
percent less dementia in the people with the highest cholesterol and in the 79 year old group
it was still a 55 percent less dementia so what this means is that cholesterol is neuroprotective
it protects you against dementia and now you may be thinking well maybe i have to sacrifice my
brain a little bit as a trade-off for better heart health and they often claim that it is
beyond the shadow of a doubt it's very very clear that cholesterol medication reduces cholesterol
and reduces plaquing and heart disease and that may or may not be true depending on
what study you look at but what if you're just lowering cholesterol and then dying from something
else so when we look at all cause mortality dying from for any reason and this was a study in Lancet
in 1997 we see the people with the lowest cholesterol we put them at a hundred as a as
a reference and then we see the people with medium cholesterol had 40 percent less mortality and the
people in the group with the highest cholesterol had a 60 reduction in all-cause mortality
so again what they're saying you're less likely to die for any reason if you have higher cholesterol
but here's the one I hear the most still because people they go low carb they cut out the sugar
they start improving their health they feel better and then they're still scared because
someone tells them that a low carb high fat diet will raise your cholesterol and they specifically
say that you can't eat all that meat and all that butter because saturated fat will increase your
LDL is that true well maybe i think there is maybe a correlation that saturated fat will increase but
what we see is that it increases the fluffy LDL the buoyant harmless LDL and what happens
with sugar carbohydrates and processed seed oils these are the things that cause inflammation and
oxidative stress they will increase the small LDL so even if you eat saturated fat and have a higher
total level of LDL what we're concerned with is what percentage of the LDL has been damaged
and now you're probably wondering then the example that I gave you what did this guy do did he eat
low fat like they recommend no he ate more meat and vegetables and butter and more saturated fat
but he ate less fast food because he had had some bad habits in the past that we
got rid of and he pretty much cut out all the sugar and he reduced his carbohydrate
now the thing to understand I made this point before I want to make it again that you have to
cut the carbohydrates low enough to dramatically reduce insulin you can't go from 60 carbohydrate
to 30 percent carbohydrate and call that low carb because you're still making too much insulin and
now with all that insulin you still can't burn through that saturated fat you have to lower
sugar eliminate sugar and lower the carbohydrates enough that there's a significant change in your
insulin now that saturated fat is good for you and because this person came to our office we
also put them on very specific supplements a very specific program and what was so specific
we identify the root causes that this person needed to handle
and for him it was scars first of all because scars interfere with the meridian with the
acupuncture chi that flows in the skin if you have scars then that distorts that information
electromagnetic fields was a big thing so electromagnetic radiation from wi-fi and
Bluetooth and cell phones and laptops and iPads and things like that can distort the communication
that your body is trying to send he also had some chemical issues we needed to gently detoxify
he had some digestive intel food intolerances he gave him some digestive enzymes then he was low in
vitamin d that was a simple one and he also needed a little bit of immune support and down the road
he needed a little bit of adrenal support so why am I mentioning this because so many people ask me
that does Ashwagandha work does turmeric work is vitamin d good
vitamin d is good for you if you're low in vitamin d you should add some but if you have a headache
or a digestive problem a thousand different people with a headache could have a thousand different
root causes so we're not addressing the headache we're addressing the root cause and that is the
only way that we can create long-term change and when they tell you you need to get on a
cholesterol medication if you still have high cholesterol after trying diet and exercise
so which diet are they talking about because if you don't understand the things we talk about
in these videos chances are that what you have tried have been heart healthy diets recommended
by the mainstream who are low-fat lean meats lots of fruits grains and seed oils and while you're
much better off if you eat this from whole food rather than eating sugar and fast food
for most people it's still not enough to make a big difference because you're not reducing
insulin enough to turn around that metabolic syndrome also we want to understand what
exercise are they talking about because people usually have the mindset of no pain no gain so
if you go and you join the so-called boot camp in the gym at five in the morning where they try to
exhaust you as much as possible in 45 minutes that may be the exact opposite of what you're
trying to do to burn fat because these boot camps will put you into a glycolysis into an anaerobic
metabolism where you break down sugar and when you break down the sugar you're going to get cravings
for more sugar and more carbohydrate and you're going to drive up your cortisol you're going to
break down muscle and you're going to create more stress and more inflammation if you do that wrong
so again there may be a very small percentage of genetic defects that could benefit from a
cholesterol medication but don't jump on one until you have done the correct diet and exercise for
a while and you understand what you're trying to change but here's what still happens a lot
i get people coming in and they might report on a video on YouTube and they say I feel amazing
my weight my glucose my a1c my insulin values my triglycerides my HDL my small LDL my VLDL my sleep
and pain they're all better I feel amazing but I'm still worried because my cholesterol is high
with all of this getting better now all I want is to bring my cholesterol down how do I do that
and the answer is you don't if all of these other values are better you are getting healthier
now I'm not saying that there is a number where you don't have to worry but 200
250 300 350 are probably totally fine if everything else looks good
if it's 500 700 thousand then I don't know then you need to have a discussion with somebody
now what if all the things that I've talked about are looking good or heading in the right direction
but you still have some doubts this is where you go for a calcium score or a coronary artery
calcium score so what they do is they do an imaging of your heart and your coronary arteries
and you get a number back so it's going to depend on the lab that performs it and where you are what
units they use and what the scale is the one I get back usually goes from 0
to 400 or higher and here's what that means if you get back a zero that's a negative test that
means you have no plaque that there's a very low risk for a heart attack or a myocardial infarction
if you're between 1 and 10 now there may be some plaque but if it's there it's going to be minimal
and you're still very low risk if it's between 11 and 100 you have mild plaque mild heart disease
but you're still at a mild risk for a heart attack if your numbers come back between 101 and 400 now
you have moderate heart disease there is some plaquing present and you have a moderate risk of
heart attack and if your number comes back over 400 then there is a large amount of plaque it's a
high probability that one or more of your coronary arteries have a substantial amount of blockage and
there's a relatively high risk of a heart attack in the next five years but very very few people
i don't think I've ever had anyone come back in this number so what is this talking about
that if they're trying to tell you that your high cholesterol
indicates that you are a candidate for heart disease why don't we just find out why don't we
take a picture and see if it's actually there and there's not a 100 correlation between the
calcium and the plaque because they're measuring the calcium and only indirectly guessing how
much plaque there is but there's a pretty good correlation there and it's a very inexpensive
test now get this insurance doesn't pay for this they'd rather pay tens of thousands of dollars
for cholesterol medication than to spend a hundred dollars on a test like this to actually find out
so if you're in doubt get with your doctor and have them order a calcium score and then you can
evaluate depending on what the results are when you get it back if you're on the top half of this
then you know you're in pretty good shape and in a few years you have another score and you make sure
that it's not getting worse then you can consult and evaluate with your doctor and at my office
wellness for life we have a department that can help you get some blood work and a consultation
to help you understand your blood work and if necessary or appropriate could get you a
calcium score after that I'll also put a link down below for five percent off on CoQ10 if you don't
have a good source already. If you enjoyed this video make sure you check out that one. And if you
truly want to master health by understanding how the body really works, make sure you subscribe,
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