Dr. Jeffrey Goldberg: How to Improve Your Eye Health & Offset Vision Loss

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welcome to the huberman Lab podcast

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where we discuss science and

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science-based tools for everyday life

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I'm Andrew huberman and I'm a professor

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of neurobiology and Ophthalmology at

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Stanford School of Medicine

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today my guest is Dr Jeffrey Goldberg Dr

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Jeffrey Goldberg is the chair of the

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Department of Ophthalmology at Stanford

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University School of Medicine he is a

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clinician and MD or medical doctor who

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sees patients every week as well as a

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PhD meaning a laboratory scientist who

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directs his own laboratory focused at

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understanding the mechanisms and cures

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for diseases of the eye Envision such as

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glaucoma retinitis Pigmentosa and

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macular degeneration indeed Dr Goldberg

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is one of the world leaders in

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developing methods to cure blindness he

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is also intensely knowledgeable about

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all things related to Vision so during

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today's discussion we indeed cover most

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all of visual and Eye Health you will

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learn for instance about the benefits as

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well as drawbacks of wearing corrective

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lenses such as contact lenses or

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eyeglasses for reading you will learn

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about the benefits and detriments of

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sunlight meaning how it can help your

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vision in fact how it can help reverse

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or prevent my own Opia nearsightedness

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as well as the things to be cautious

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about with respect to sunlight in terms

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of development of cataracts which are

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occlusions that prevent Vision we also

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discuss many tools for maintaining and

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improving Vision across the lifespan

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ranging from behavioral tools so

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specific Vision tasks and exercises for

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the eye that you can do that are known

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to improve or maintain your vision as

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well as specific surgical procedures

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such as LASIK surgery we get into all

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the details of for instance how often to

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do these various eye exercises how long

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the benefits are maintained as well as

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age-related considerations for things

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like Lasik eye surgery we even get into

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how to best clean your contact lenses

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whether or not to use disposable contact

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lenses or other forms of contact lenses

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we also discuss things like dry eye and

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the best remedies for dry eye and we

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talk about the scientific and clinical

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data around nutritional approaches and

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supplementation-based approaches for

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maintaining and improving Vision so

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whether or not you suffer from floaters

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or dry eye or you're considering

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changing your eye prescription or you

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have concerns about whether or not

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relying on corrective lenses is

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impairing your vision and you want to

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enhance your vision or if you're

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somebody who has perfect vision today's

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episode is going to include science and

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protocols that will be highly relevant

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to you I should also add that if you are

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somebody who suffers from or who has

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family members who suffer from diseases

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of the eye that can impact Vision such

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as glaucoma retinitis Pigmentosa and

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macular degeneration we also delve deep

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into the discussion about the most

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Advanced Technologies for preventing and

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offsetting vision loss due to those

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diseases as well thanks to Dr Goldberg's

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incredible knowledge his Clarity of

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communication and his generosity with

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that knowledge by the end of today's

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episode You Will Be armed with all of

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the modern information you need in order

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to best maintain and improve your eye

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and vision health before we begin I'd

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like to emphasize that this podcast is

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separate from my teaching and research

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roles at Stanford it is however part of

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my desire and effort to bring zero cost

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to Consumer information about science

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and science related tools to the general

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public in keeping with that theme I'd

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now for my discussion with Dr Jeffrey

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Goldberg Dr Jeffrey Goldberg welcome

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thanks it's great to be here you and I

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go way back

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we will spare people the discussion

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about all of that but

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I'm really excited for today's

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discussion because I get a tremendous

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number of questions about vision and Eye

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Health and of course as a neuroscientist

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who has worked on the visual system I

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sometimes have answers or partial

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answers but more often than not I don't

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have the answers

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and yet I'm confident that you do or

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that if you don't you can direct us to

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the proper place to get those answers so

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to kick things off I want to ask you

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what was one of the most commonly asked

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questions when I solicited for questions

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in anticipation of this episode which is

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how early should one do an eye exam on

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their child and how regularly should we

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all be doing eye exams

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also

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is the fact that I think I can see

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normally confirmation that I can see as

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well as I think I can so that's really

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three questions but baby comes out do

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they check their eyes right away and if

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so how and how often should they check

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and what kind of information is there

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yeah it's as a great question it's

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obviously something that touches us all

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so the the answer that really differs a

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little bit uh at the different stages of

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Life first of all every every baby gets

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an eye exam or should be getting an eye

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exam and uh one of the main things that

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you really just are screening for right

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when that baby is born right in the

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nursery right in those first few days is

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to just look for a red reflex you know

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when you take a camera picture a Flash

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picture and sometimes you get red eye

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that's actually the light from the flash

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as you know reflecting against the

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retina coming back out of your eye it

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looks red and

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um and a red reflex is actually very

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normal that's that that's great and if

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you have a one of a number of

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diseases in the eye that can present

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even in babies even in newborn babies

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including most concerning but thankfully

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least common retinoblastoma which is the

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most common pediatric eye cancer which

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again thankfully is quite rare uh those

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babies won't have a red reflex in that

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eye it'll be kind of a whitish or gray

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reflex and so even just that first

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little you know doctor's taking the

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little pen light and even just flashing

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it in that's in the baby's eyes so

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that's that's that's our first eye exam

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and hopefully we've all had that and

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hopefully every baby being born today is

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getting that getting that first eye exam

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is really just looking for that red

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reflex

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uh it's not typical as long as that's

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looking good

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um to worry about getting an eye exam

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from there kind of through

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um childhood like maybe early Elementary

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School unless they your baby is

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presenting with one of a number of

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features that parents often pick up on

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for example as the baby's aging through

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those first couple of years you know

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through the first couple of years babies

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actually don't have great visual Acuity

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and so as they're aging over those first

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couple years it's normal for them to

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have you know roving eye movements for

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example be searching their environment

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but over those first couple of years if

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parents start noticing the baby isn't

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you know isn't uh making eye contact or

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looking where a sound is certainly if

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they have what's called nystagmus like

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these rapid flickering alternating eye

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movements uh anything like that of

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course you're going to trigger trigger

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an eye exam but otherwise most babies

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other than their pediatrician doing that

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red reflex check when they're in for

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their regular well child checks uh

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that's really all that's uh needed

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through that when most kids get to

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elementary school age there will often

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be often done at the schools and

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amblyopia screening exam if kids eyes

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either if one eye doesn't see that well

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like maybe you're very nearsighted or

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farsighted in one eye and pretty normal

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sighted in the other or the two

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refractive errors are quite different

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from each other that can lead to a

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condition you've talked about on the

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podcast before called amblyopia which is

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probably one of the more common or most

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common eye diseases of children

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or if the eyes are in a line you know

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our eye muscles and the Brain behind

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them are really responsible for keeping

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the two eyes looking straight ahead and

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if that's not working properly and one

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eye is is off kilter and therefore the

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image of what we're looking at is

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falling on different spots of the retina

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it's not sinking upright in the brain

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that can lead to this disease condition

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called amblyopia where that eye is no

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longer talking to the brain properly and

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there's a pretty easy screening exam

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that can be done for strabismus the

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misalignment of the eyes that kids will

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do in elementary school the other main

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presenting symptom of kids in elementary

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school is when they admit to their

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parents I can't see the board or I can't

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see the teacher up front and then they

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might be quite nearsighted and so that

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will also trigger an exam and so those

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are usually the parts for for babies for

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toddlers for children school-aged

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children that might reasonably trigger

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an exam a couple of questions about

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early eye exams and we'll um get on to

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uh eye exams in older visuals in a

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second but I want to interrupt you with

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this question so you mentioned that um

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you know there can be a misalignment of

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the eyes I've seen many people's babies

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where there is one eyeball that seems to

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be kind of drifting around and then it

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might correct but sometimes they'll have

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a we don't want to get technical here

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for our listeners we'll keep it General

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but either convergent eyes or one eye

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converging cross eyes or walleyed you

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know again using uh that non-technical

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language here

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um and my understanding is that the

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brain is taking that information in and

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it's very plastic it's changing at these

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early stages of development and that

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it's fairly critical to get that stuff

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corrected early on because if you wait

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too long the brain can essentially

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become blind to the the um or rather the

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the brain cannot learn to handle the

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proper alignment so in other words if a

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kid has cross eyes

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crossed eyes excuse me and they're not

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corrected uh until their 20s it's

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possible that they will never recover

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normal vision whereas if you recover if

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you align the eyes properly early in

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development they can indeed recover

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Vision how early can and should one

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consider getting those eye realignments

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done yeah yeah pretty much right on what

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they'll do is if they detect any eye

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misalignment and sometimes parents are

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are good at noticing that and sometimes

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you take a picture and one eye got the

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red eye reflex and the other one didn't

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and sometimes people notice that their

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kids eyes are sort of turning in it

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seems like too much

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um sometimes there's what's called

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pseudostrabismus which is where actually

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depending on your Anatomy if you have a

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little extra skin sort of on the inside

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corners of your eyes it makes your eyes

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look turned in when actually they're

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straight but if your eyes are actually

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turned in or slightly less common in

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children more common in adults

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misalignment turned out

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it's really important to correct that

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early and the reason is as you were

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saying the brain starts ignoring it it

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fails to fully develop the straw wrong

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connections from the for the data coming

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in from one of those two eyes into the

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brain and if you pass certain sort of

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thresholds during development during

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childhood without correcting that

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connectivity getting those two eyes to

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work together properly you can

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permanently lose that

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um and so we use sort of we used to use

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very sort of uh you know gross numbers

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like it's fully correctable if you can

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intervene before age three it's partly

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correctable if you can intervene before

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age six you got a chance before age nine

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but it turns out in follow-on studies

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that even kids into their young teens

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have a shot at correcting that I brain

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connection that amblyopia that that loss

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of vision uh that that can occur during

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early development so even if you're only

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you know unfortunately detecting that

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later on in childhood or even sort of

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the tween years or early teen years it's

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still worth a try to really push to

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um retrain the weaker eye and then also

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realign the muscles so that they can

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work together to keep the eyes focused

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I'll tell you it's interesting and

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there's a lot more to learn about brain

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plasticity and probably a lot of really

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cool new

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therapies yet to discover that could

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reopen what's called critical period

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plasticity this this this plasticity

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that we have during development that

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kind of goes away as we age and and that

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critical period plasticity as you know

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has been the best studied actually in

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the visual system and the idea that we

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could reopen that is really fantastic

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but for different parts of that ibrain

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connection there's different periods for

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critical period plasticity for example

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even if you get the amblyopic eye to see

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well again and then you realign the eyes

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and now they're working together a lot

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of kids will never recover full depth

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perception stereopsis the use of two

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eyes to see depth for example so why

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that part of the brain doesn't

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correct as well as the visual Acuity or

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central vision part of the brain I'm not

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sure if we understand that yet

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I'm going to ask for a curbside consult

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as sometimes called right now by telling

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you a story when I was a kid I went

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swimming without goggles and I had one

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eye closed and the other eye open and

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closing as it went in and out of the

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water because I'm a deficient swimmer

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and I only breathe to one side

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unless I really consciously forced

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myself to breathe to both sides in a

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freestyle swim got out of the pool and I

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was seeing double

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it was pretty eerie and then it became

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downright scary because I didn't recover

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my double vision until they patched one

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of the eyes to forcing me to use the

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other eye that had been closed the

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entire time

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and fortunately this was done early

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enough and it I was young enough that

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within I think it was about a day or so

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I restored what normal vision however my

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depth perception is terrible

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um I'm the kid that you know Fly ball

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was hit to me in the Outfield and it's

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coming it's coming and then it hit me

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this is why I've generally focused on

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foot Sports throughout my entire life as

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opposed to you know precise hand-eye

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coordination I'm better at throwing

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darts and things with one eye closed

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than I ever would be with both eyes

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maybe that's true for most people

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question I have is

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is it true that even just a few hours of

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misalignment of information to the two

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eyes early in development can

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permanently rewire the brain unless

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there are some corrective measures such

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as patching up one eye and the example I

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gave is just one but for instance if um

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uh you know someone injures you know

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gives a scratch on their cornea and they

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close they patch the eye and the person

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happens to be 10 years old is it

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important to then patch the other

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healthy eye after the the um you know

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the scratched eye is feeling better in

Time: 1058.52

other words how critical is it to ensure

Time: 1060.919

the balance of information coming into

Time: 1063.14

the two eyes even on the order of hours

Time: 1065.419

or days yeah your story is uh it has

Time: 1069.2

some features of uh you know totally

Time: 1071.78

usual how we think about misaligned eyes

Time: 1074.419

leading to amblyopia where one eye is

Time: 1076.76

weaker patching the strong eye so the

Time: 1079.039

weak eye can recover but not necessarily

Time: 1081.44

fully regaining depth perception and so

Time: 1084.08

that part of it is you know quite

Time: 1087.039

stereotypical the part of your story

Time: 1089.48

that's atypical is that for most kids

Time: 1093.86

um an hour to let alone minutes an hour

Time: 1096.5

to even an hour to a day if you were I

Time: 1100.1

don't know if you were a young kid and

Time: 1101.36

you just really were training up on

Time: 1103.34

throwing darts and you were just keeping

Time: 1105.26

one eye closed to throw the darts you

Time: 1107.12

know really practicing for an hour a day

Time: 1108.98

it'd be very unusual for that to trigger

Time: 1112.94

this kind of either strabismus

Time: 1115.1

misalignment of the eyes let alone

Time: 1116.62

amblyopia and the strabismus is what's

Time: 1119.36

giving you the double vision because

Time: 1120.559

they're misaligned let alone the

Time: 1122.2

amblyopia of one eye turning out weaker

Time: 1124.58

if I had to guess of course not having

Time: 1127.039

you know done your exam before that

Time: 1129.08

fateful day in the swimming pool if I

Time: 1131.419

had to guess I would guess that you may

Time: 1133.34

have had some intermittent business and

Time: 1137

your brain was already getting kind of

Time: 1139.22

hit

Time: 1140.48

and and you neither you nor your parents

Time: 1142.94

may have even noticed it it could be

Time: 1144.5

happening you know at other times a day

Time: 1146.12

or you're not kind of really paying

Time: 1147.679

attention it doesn't kind of stand out

Time: 1149.539

in the way that that that day that you

Time: 1152.059

got out of the swimming pool you really

Time: 1153.5

noticed it and it may not have been that

Time: 1155.059

strong it may have been quite

Time: 1155.96

intermittent but if you had had some

Time: 1158.24

years of intermittent isotropia or

Time: 1160.94

turning in of the eyes or exotropia

Time: 1163.22

turning out of the eyes that just

Time: 1165.14

happened here and there but was

Time: 1166.48

accumulating sort of uh damage or

Time: 1170

failure to connect over years leading up

Time: 1172.7

to that day in the swimming pool and

Time: 1174.5

that day just tipped you over the edge

Time: 1176.059

and you've got double vision you really

Time: 1177.559

noticed it that led to an eye exam and

Time: 1180.26

an eye care provider and they said wait

Time: 1182.12

a second this size stronger this size

Time: 1183.799

weaker you've got a little amblyopia

Time: 1185.9

we're going to start patching your

Time: 1187.16

strong eyes so you can get your weak eye

Time: 1188.6

back so for 99.9 percent of the kids who

Time: 1191.66

like you know yeah they get a little

Time: 1193.52

corneal scratch or they're patching one

Time: 1195.32

eye closed or or uh you know anything

Time: 1199.1

that's sort of a rare event like that

Time: 1201.26

nothing to worry about parents don't

Time: 1203.36

have to worry kids can be kids they can

Time: 1205.34

play they can do that kind of thing and

Time: 1207.919

uh and not have to worry and and it's

Time: 1209.96

unfortunate that we can't tell in

Time: 1211.28

advance

Time: 1212.539

which kid's been having the intermittent

Time: 1214.52

amblyopia because we don't do a standard

Time: 1216.559

eye exam on every five-year-old who's

Time: 1218.96

not complaining of anything but but yeah

Time: 1221.419

so that's a that's an unusual case in

Time: 1223.34

yours and if I had to guess I I would

Time: 1224.9

bet that you were having some sort of

Time: 1227.26

subclinical untracked Uncharted

Time: 1230.5

unnoticed maybe strabismus leading up to

Time: 1233.9

that point okay great thank you you can

Time: 1236.059

send me a bill at the end

Time: 1237.98

um

Time: 1238.64

along those lines

Time: 1240.679

I'm 47 years old so I was part of the

Time: 1244.039

generation that grew up with some

Time: 1245.96

computers in the classroom but not a lot

Time: 1247.64

nowadays

Time: 1249.86

kids from a very young age are looking

Time: 1251.9

at iPads and

Time: 1253.4

phones and screens and things very close

Time: 1257.36

up and there is a wealth of experimental

Time: 1260.539

animal data showing that if you limit

Time: 1262.7

Vision to just close range that the

Time: 1266.66

eyeball lengthens and therefore the

Time: 1269.059

visual image Falls in front of and not

Time: 1271.94

directly onto the neural retina the

Time: 1274.76

essentially the light sensing portion of

Time: 1276.919

the of the eye and those animals become

Time: 1280.58

myopic or nearsighted

Time: 1283.1

what can we say about the environmental

Time: 1285.799

conditions in which kids are seeing

Time: 1289.82

from the time they're born through let's

Time: 1292.34

say adolescents and their teen years in

Time: 1294.38

terms of

Time: 1295.22

how their visual system wires up and are

Time: 1298.46

there any recommendations that are

Time: 1301.159

coming from the scientific literature

Time: 1302.9

clinical studies clinical trials excuse

Time: 1305.12

me or otherwise that indicate what a

Time: 1308.78

healthy visual environment consists of

Time: 1311.059

yeah yeah that's a great question and

Time: 1314.12

actually it's really relevant these days

Time: 1317.179

because uh you know myopia is so common

Time: 1321.58

uh it's more common

Time: 1325.1

um

Time: 1325.76

an Asian populations you know it's

Time: 1328.88

called an epidemic in China in

Time: 1331.82

California we have a lot of Asian

Time: 1333.919

Heritage or Asian Americans and so we

Time: 1336.14

see a lot like at Stanford we see a lot

Time: 1338.539

of

Time: 1340.039

um you know myopia in kids on adults and

Time: 1343.88

really starting to get thoughtful on the

Time: 1345.74

science of myopia control how do we how

Time: 1348.559

do we provide the right environments now

Time: 1350.6

what's interesting is that for decades

Time: 1352.78

the Assumption some of the data really

Time: 1357.44

led us to the path of thinking like gosh

Time: 1359.6

the more you spend near activities and

Time: 1362.48

these are Mouse model experiments like

Time: 1364.4

you described but also well-designed

Time: 1366.98

human cohort studies you know figuring

Time: 1368.96

out like asking you know kids and

Time: 1371.12

families like how long is your kid

Time: 1372.679

reading or in front of the computer how

Time: 1374.78

myopic are they how nearsighted are they

Time: 1376.76

versus how much time is your kid in

Time: 1379.82

front of the computer doing near work

Time: 1381.62

how myopic or nearsighted are they and

Time: 1384.32

these well-designed cohort studies did

Time: 1386.24

Point tour words this concept that if

Time: 1389.24

you do too much near work as a kid that

Time: 1392.539

you're more likely to develop

Time: 1394.84

nearsightedness as you get through those

Time: 1396.919

those sort of you know uh pre-teen and

Time: 1399.679

even into the teen years which is when

Time: 1401.659

most of that myopia progression or

Time: 1403.76

eyeball elongation is actually happening

Time: 1406.46

to cause nearsightedness

Time: 1408.559

it's only been in the last few years

Time: 1410.9

that some really exciting Studies have

Time: 1412.88

actually pointed in a slightly different

Time: 1414.62

direction

Time: 1416.72

and that's that maybe it's not all not

Time: 1419.299

to say it's not about near activity but

Time: 1421.58

maybe it's not all about near activity

Time: 1423.14

maybe it's actually a little more about

Time: 1425.059

the kind of light we're getting into our

Time: 1427.88

eyes and I think you've talked about

Time: 1429.62

this before and it's really important

Time: 1431.299

when they've now studied and asked the

Time: 1433.52

kids instead of just how much near and

Time: 1435.08

how much far are you doing how much time

Time: 1437.24

are you spending indoors in indoor

Time: 1439.159

lighting which doesn't have full

Time: 1440.48

spectrum light in a typical indoor

Time: 1442.28

environment versus how much time are you

Time: 1444.08

spending Outdoors

Time: 1445.7

playing in the yard you could be reading

Time: 1447.98

outside but what are you just what kind

Time: 1449.9

of time are you spending outside and and

Time: 1453.32

of course when you're outside in

Time: 1454.94

sunlight even it's in direct sunlight

Time: 1456.919

you're getting a different spectrum of

Time: 1458.78

kind of Full Spectrum Lighting from the

Time: 1460.58

sun and it looks like it's pretty clear

Time: 1463.58

now actually that it has maybe more to

Time: 1466.1

do with outdoor lighting time than just

Time: 1470.72

near work and so I think that you know

Time: 1474.14

we we've we've actually already seen the

Time: 1476.72

first couple randomized controlled

Time: 1479.179

trials where they're having kids

Time: 1481.48

intentionally spending time Outdoors

Time: 1484.159

versus sort of Standard Life which you

Time: 1486.679

know is going to be often much more

Time: 1488.36

indoor time and uh and seeing some

Time: 1491.299

effects you follow those kids over a

Time: 1493.22

couple of years and the kids who spend

Time: 1496.159

time Outdoors are are progressing in

Time: 1499.34

their nearsightedness less like they're

Time: 1501.38

they're nearsighted prescription is not

Time: 1504.02

getting as strong as the kid kids who

Time: 1506.059

are spending more time indoors and

Time: 1508.039

there's some pretty good biology that's

Time: 1509.72

getting worked out going back to animal

Time: 1511.28

models more about about how that might

Time: 1513.74

be working in the retina in this inside

Time: 1516.2

the eye but it's pretty compelling uh

Time: 1519.62

concept and and so you know as a parent

Time: 1521.659

uh you you may want to be you may want

Time: 1524.299

to be telling your kid like okay yeah I

Time: 1526.64

want you to read that book or you know

Time: 1528.62

if your kids plan on the phone or

Time: 1530.779

something like that or the iPad or

Time: 1532.34

something like that they're allowed that

Time: 1533.72

time okay you can have that time but I

Time: 1536.179

want you to spend some of the time that

Time: 1537.62

you're doing that Outdoors are there any

Time: 1539.72

thresholds for the amount of time that

Time: 1541.58

one would suggest their child be

Time: 1543.62

outdoors to get that full spectrum light

Time: 1546.26

it's a great question you know we talk

Time: 1548.24

about cohort studies where we just ask

Time: 1551.419

people what are they doing and there

Time: 1553.52

seems to be you know a little bit of

Time: 1554.84

what we would call a dose dependent

Time: 1556.46

response maybe the more time Outdoors

Time: 1558.32

might be better we don't know if there's

Time: 1560

an upper limit like gosh if you go over

Time: 1561.86

two or three hours there's no additional

Time: 1563.9

benefit talk about that cohort studies

Time: 1566.6

the real gold standard for answering

Time: 1569.36

these kinds of questions are randomized

Time: 1572.779

controlled trials and specifically

Time: 1574.9

placebo-controlled or or a control group

Time: 1577.159

that's not getting the intervention

Time: 1578.72

that's our highest level of evidence for

Time: 1581.539

clinical evidence for for any of this

Time: 1583.58

kind of science when we're talking about

Time: 1585.5

humans or pre-clinical models in the

Time: 1587.539

laboratory and the study that hasn't

Time: 1590.9

been done yet to really answer that

Time: 1592.88

question is to randomize kids to telling

Time: 1596.12

this group of kids you just do your

Time: 1598.22

normal life tell this group of kids we

Time: 1600.32

want you outside an hour this group of

Time: 1602.6

kids we want you outside two hours a day

Time: 1604.64

this group occurred three hours a day

Time: 1606.62

and see between the groups is there a

Time: 1609.5

big difference like we have pretty good

Time: 1611.36

evidence now from the studies that have

Time: 1612.919

been done that the difference between

Time: 1614.6

zero

Time: 1616.22

and one or two hours is clearly There is

Time: 1619.82

five minutes enough is five hours better

Time: 1622.279

I don't think we know the answers to

Time: 1624.02

those questions yet like what's the

Time: 1625.76

right dose but there's probably at least

Time: 1628.46

some dose dependence to that and it I

Time: 1631.76

can imagine it's a little bit hard to

Time: 1633.02

tease apart the near far viewing from

Time: 1635.36

the indoor outdoor because yes of course

Time: 1637.76

a child could be outside on an iPad up

Time: 1640.64

close

Time: 1641.48

but it's hard to imagine that at some

Time: 1643.279

point they aren't seeing off into the

Time: 1644.659

distance far viewing as it's called and

Time: 1648.08

the reverse is also true if you're

Time: 1649.64

indoors unless you live in a very very

Time: 1651.44

large home or you're staring off a

Time: 1653.539

balcony far viewing is much harder to

Time: 1656

achieve yeah so it's and perhaps it

Time: 1659.12

isn't important to isolate these

Time: 1660.559

variables although I can see the

Time: 1661.82

challenge in developing a really good

Time: 1663.32

clinical trial randomized clinical trial

Time: 1665.299

for this meanwhile I I you know I'm con

Time: 1667.94

I'll go into the grave shouting you know

Time: 1670.4

or saying rather and suggesting that

Time: 1672.74

people get some morning sunlight in

Time: 1674.059

their eyes to set their circadian rhythm

Time: 1676.4

um but far viewing a few at least a few

Time: 1679.94

minutes and ideally hours per day or a

Time: 1682.64

mixture of near and far viewing by being

Time: 1684.32

outdoors just seems like a good thing to

Time: 1686.6

do regardless of age so are there any

Time: 1688.46

data in older people not necessarily

Time: 1691.279

elderly but older people so um people in

Time: 1693.44

there from say 25 years of age into

Time: 1696.5

their 60s or 70s that getting outdoors

Time: 1698.72

and getting this full spectrum light is

Time: 1701.12

healthy for the eye in ways that are

Time: 1703.64

separate from the known healthy effects

Time: 1705.44

of doing that on circadian rhythm

Time: 1706.88

setting yeah yeah the Circadian Parts

Time: 1709.039

pretty clear the

Time: 1712.279

and most patients and most in most

Time: 1714.38

people the new the development of

Time: 1716.419

nearsightedness happens a lot until age

Time: 1718.52

10 little more through age 20. a little

Time: 1722

more than that into the in you know in

Time: 1724.1

through the 20s up to 30. tiny bit in

Time: 1727.159

the 30s up to 40. but usually by those

Time: 1730.4

later ages your prescription might be

Time: 1732.86

changing a quarter of a diopter that's

Time: 1735.74

the measurement that we use when we you

Time: 1737.48

know give you your glasses prescription

Time: 1739.039

a quarter of a diopter half a diopter it

Time: 1742.4

could get a half after more nearsighted

Time: 1744.32

or less nearsighted you know once you're

Time: 1746.6

aging into your 40s 50s and Beyond so

Time: 1749.6

most of the action on nearsightedness

Time: 1752.24

development is actually really happening

Time: 1754.34

in the younger ages so again the the

Time: 1757.279

premise of intervening in an older

Time: 1759.44

person and I'll just include you and me

Time: 1761.72

and older people for the sake of this

Time: 1763.46

definition as much as I'm reticent to do

Time: 1765.38

that in general

Time: 1767.059

um I think the the premise of Inc of of

Time: 1770.299

sort of light modulation from

Time: 1772.48

nearsightedness in older people is

Time: 1775.039

probably probably not so strong I think

Time: 1777.44

there are a lot of other benefits you've

Time: 1779.12

talked a lot about circadian rhythm

Time: 1781.64

there are so many health benefits to

Time: 1783.98

exercise and you know if you're getting

Time: 1785.659

Outdoors there's a good chance you're

Time: 1787.34

going to be walking or bicycling you

Time: 1789.62

know so so exercise value for the health

Time: 1792.08

of our eyes and the rest of our body is

Time: 1794.12

clearly there

Time: 1795.679

um but I don't know that there's really

Time: 1797.12

a strong premise that you're going to

Time: 1799.159

change your glasses prescription you

Time: 1801.74

know in our 40s or 50s or Beyond I'd

Time: 1804.679

like to take a quick break and

Time: 1806.179

acknowledge one of our sponsors athletic

Time: 1808.22

greens athletic greens now called ag-1

Time: 1810.86

is a vitamin mineral probiotic drink

Time: 1813.38

that covers all of your foundational

Time: 1815.12

nutritional needs I've been taking

Time: 1817.1

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delighted that they're sponsoring the

Time: 1820.88

podcast the reason I started taking

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athletic greens and the reason I still

Time: 1824

take athletic greens once are usually

Time: 1826.1

twice a day is that it gets to be the

Time: 1828.62

probiotics that I need for gut health

Time: 1830.36

our gut is very important it's populated

Time: 1832.52

by gut microbiota that communicate with

Time: 1835.159

the brain the immune system and

Time: 1836.419

basically all the biological systems of

Time: 1838.279

our body to strongly impact our

Time: 1840.38

immediate and long-term health

Time: 1842

and those probiotics and athletic greens

Time: 1844.22

are optimal and vital for microbiotic

Time: 1847.159

health in addition athletic greens

Time: 1849.26

contains a number of adaptogens vitamins

Time: 1850.94

and minerals that make sure that all of

Time: 1852.62

my foundational nutritional needs are

Time: 1854.24

met and it tastes great if you'd like to

Time: 1857.299

try athletic greens you can go to

Time: 1858.94

athleticgreens.com huberman and they'll

Time: 1862.1

give you five free travel packs that

Time: 1863.72

make it really easy to mix up athletic

Time: 1865.34

greens while you're on the road in the

Time: 1867.02

car on the plane Etc and they'll give

Time: 1869.059

you a year's supply of vitamin d3k2

Time: 1871.64

again that's athleticgreens.com huberman

Time: 1874.22

to get the five free travel packs and

Time: 1876.14

the year supply of vitamin D3 K2 it's

Time: 1879.02

probably worth touching on some of the

Time: 1880.399

do's and some of the don'ts for Eye

Time: 1882.08

Health generally and then I promise I'm

Time: 1885.08

going to get us back to adult eye exams

Time: 1886.82

because I have a lot of questions about

Time: 1888.679

that

Time: 1890.059

I can imagine that it's probably not a

Time: 1892.76

great idea to be exposed to extremely

Time: 1894.919

bright light and this is why people who

Time: 1896.899

weld wear eye Shields but of course most

Time: 1900.799

people are not welding

Time: 1902.84

um

Time: 1903.5

what other sorts of environmental

Time: 1905.299

conditions are detrimental to our vision

Time: 1907.58

health across the lifespan including

Time: 1910.58

brightness of light we talked a little

Time: 1912.919

bit about near far obviously we want to

Time: 1915.5

keep toxins and acids and solvents and

Time: 1917.96

things out of the eye but what do you

Time: 1919.34

see

Time: 1920.299

I'm not because hopefully not commonly

Time: 1922.039

but what are some of the things that you

Time: 1923.899

feel might not be discussed enough in

Time: 1925.64

terms of Eye Health yeah you know I

Time: 1928.7

think at all ages eye safety is

Time: 1932.36

something that we don't talk about

Time: 1933.559

enough

Time: 1935.059

um you know our eyes are delicate the

Time: 1939.38

front surface of the eye the cornea the

Time: 1941.6

Clear Window that lets the light go into

Time: 1943.34

your eye that's a delicate very

Time: 1945.74

sensitive structure it's thin maybe a

Time: 1948.32

millimeter at the thickest a half

Time: 1950.299

millimeter in the center of our eye

Time: 1952.64

uh the retina is it it's neural tissue

Time: 1956

this is like really an outgrowth of the

Time: 1957.559

brain this is very sensitive it's

Time: 1959.36

subject to degenerative disease and

Time: 1961.58

injury our eyes even if they just get

Time: 1964.46

hit can get very inflamed our eyes can

Time: 1967.34

be more inflammatory than a bruise on

Time: 1969.38

our skin on our shoulder might be so eye

Time: 1972.02

safety is a big one and people who are

Time: 1974.559

working in certain industries

Time: 1978.14

um you know anyone who's doing any metal

Time: 1979.76

grinding people who are even just

Time: 1982.1

gardening you know and if you're if

Time: 1983.899

you're doing some significant gardening

Time: 1985.64

and cutting and you could you know Fleck

Time: 1987.679

a little bit of dirt you know there's a

Time: 1989.36

lot of there's a lot of for example

Time: 1991.34

fungus that lives in the ground natural

Time: 1993.38

stuff it's all very normal in the in the

Time: 1995.84

Earth but you know our eyes aren't

Time: 1997.88

really made to absorb that fungus and

Time: 2001.059

and have have a piece of dirt kind of

Time: 2003.279

stick in our eye like that and so people

Time: 2006.1

are at risk I think for you know for not

Time: 2008.32

and we see too much kind of

Time: 2010.779

really unnecessary eye injury eye trauma

Time: 2014.679

that if people wore either their glasses

Time: 2017.019

because they happen to wear prescription

Time: 2018.34

glasses or goggles or for more advanced

Time: 2022.659

work you know safety goggles of course

Time: 2025.84

um if you're sanding doing wood shop

Time: 2028.24

projects anything like that sawing

Time: 2030.64

including you know again in the garden

Time: 2032.62

cutting things

Time: 2034.899

um you know I think I think eye safety

Time: 2037.179

you know eye trauma is a big one and you

Time: 2040.659

know we probably see one or two

Time: 2043.96

um what we call open Globes a week come

Time: 2046.72

into the Opera into the emergency room

Time: 2049.24

and

Time: 2051.28

um you know those are tough because you

Time: 2053.32

know again the eyes delicate and it can

Time: 2054.82

do a lot of healing but but not infinite

Time: 2057.339

right and so we really you know that's

Time: 2059.56

that's one that I think is really

Time: 2062.139

an untapped opportunity is just a little

Time: 2064.599

more education around

Time: 2067.3

um around eye protection protecting

Time: 2069.76

against eye trauma what about eye

Time: 2071.619

cleanliness there's some pretty dramatic

Time: 2073.899

videos also I've put some of these on my

Time: 2076.48

Instagram handle of these are MRIs of

Time: 2079.54

people rubbing their eyeballs and people

Time: 2081.339

really getting a sense of first of all

Time: 2083.56

a restatement of what you said getting a

Time: 2085.3

real sense of just how much the eyes are

Time: 2087.7

an outgrowth of the brain because of the

Time: 2089.56

op when you see with the optic nerves

Time: 2091.599

and all their beauty and the eyeballs

Time: 2094.24

moving around as someone rubs their eyes

Time: 2095.679

I have to imagine that rubbing your

Time: 2096.76

eyeballs a little bit isn't bad but I

Time: 2098.08

actually called you I don't know if you

Time: 2099.4

remember when I was a junior Professor I

Time: 2101.74

woke up from a nap one day and I

Time: 2103.119

couldn't see out of one eye I was

Time: 2104.92

freaking out so of course I called you

Time: 2106.26

and I had pressure blinded Myself by

Time: 2109.48

falling asleep on my hand or something

Time: 2111.28

like that and you assured me that my

Time: 2112.78

vision would come back and indeed it did

Time: 2114.339

so you play dual role of ophthalmologist

Time: 2116.26

and psychiatrist thank you and indeed I

Time: 2119.32

can see out both eyes

Time: 2121.48

um now

Time: 2123.339

um but

Time: 2125.5

rubbing our eyes getting gunk in our

Time: 2128.079

eyes you know I think unless somebody

Time: 2129.579

has lost their Vision temporarily

Time: 2132.46

it's hard to imagine this is like a big

Time: 2134.32

deal but when it happens it is truly

Time: 2136.839

frightening we're so dependent on Vision

Time: 2139

so um you know what are your

Time: 2141.04

recommendations about rubbing or not

Time: 2142.96

rubbing eyeballs about

Time: 2144.88

um hand washing and cleanliness and also

Time: 2146.92

how do you wash an eye properly yeah do

Time: 2149.38

you use soap and flush it with water or

Time: 2150.88

do you just flush it with water or

Time: 2152.14

should you not even do that should use

Time: 2153.28

saline I didn't realize these might

Time: 2154.78

sound like low level questions but these

Time: 2156.16

are the things that people deal with on

Time: 2157.78

an all too frequent basis yeah you know

Time: 2160.119

for most people most of the time

Time: 2161.98

actually the eyes are a very good clean

Time: 2164.8

environment and actually are tears are

Time: 2168.28

are contain enzymes that help break down

Time: 2171.16

bacteria and bacterial toxins and so for

Time: 2174.52

most people regular eye washing doesn't

Time: 2177.7

have to be any part of their standard

Time: 2179.56

routine in terms of the surface of the

Time: 2181.72

eye the part of your eye the conjunctiva

Time: 2183.88

uh over the whites of the eyes

Time: 2185.68

underneath the eyelids anything

Time: 2186.88

underneath the eyelids it's pretty

Time: 2188.8

self-cleaning and actually our tear

Time: 2190.599

production and blinking is very good at

Time: 2193.599

keeping our eyes clean the eyelids

Time: 2196.78

eyelashes can be another story and

Time: 2199.119

especially as we age uh we can you know

Time: 2202.359

like our skin is breaking down a little

Time: 2204.28

differently than when we were younger

Time: 2205.9

you can develop what we sort of

Time: 2208

nicknamed scurf which is like kind of

Time: 2210.16

little dead skin bits that accumulate

Time: 2212.2

around the eyelashes a lot of people

Time: 2214.18

develop what we call blepharitis which

Time: 2216.64

is just just means inflammation of the

Time: 2218.8

eyelashes yeah and for that doing some

Time: 2221.68

eye scrubs is a good idea they actually

Time: 2224.079

sell little pads that you can buy kind

Time: 2226.96

of little that you rip open and you can

Time: 2228.7

use to kind of lightly clean the

Time: 2230.14

eyelashes but you can also just use like

Time: 2233.5

a No More Tears baby shampoo just pump a

Time: 2236.74

little bit into the palm of your hand

Time: 2238.119

once or twice a day let a little uh

Time: 2241.359

dilute it with a little water and under

Time: 2243.52

the sink and either with your finger or

Time: 2245.2

an edge of a washcloth just very lightly

Time: 2247.72

rub the eyelashes what I like to do with

Time: 2249.82

the eyes closed with the eyes closed and

Time: 2251.74

don't scrunch them closed too tight

Time: 2254.079

because you're actually burying the

Time: 2255.88

eyelashes when you do the roots of the

Time: 2258.28

eyelashes when you really scrunch so

Time: 2260.92

just gently close your eyes just you

Time: 2262.78

know real gentle closure and then just

Time: 2264.88

lightly scrub it shouldn't be abrasive

Time: 2266.68

you're not trying to exfoliate the

Time: 2268.96

eyelids or eyelashes in any way just

Time: 2271.48

lightly rub with that kind of dilute No

Time: 2273.88

More Tears baby shampoo and that can

Time: 2275.8

really help people with their eye

Time: 2278.14

Comfort if you feel like you've got

Time: 2280.42

something in your eye your ideal eye

Time: 2283.24

wash is actually going to be a sterile

Time: 2285.22

Salient solution a saltwater solution

Time: 2287.8

that you know they sell little bottles

Time: 2289.78

over the counter eye wash Solutions like

Time: 2292.96

that a lot of people wear contacts will

Time: 2294.88

have that kind of eye wash solution just

Time: 2296.92

a sterile saline eye wash just pure salt

Time: 2300.099

water doesn't have to have any other

Time: 2301.599

chemicals or preservatives in it you can

Time: 2304.48

of course use not actual uh seawater or

Time: 2307.66

salt water not salt water thank you yeah

Time: 2309.7

not salt water out of your salt pool not

Time: 2311.92

salt water out of the ocean but like a

Time: 2314.74

saline salt water that's available in a

Time: 2316.9

sterile now you can also just use

Time: 2318.64

artificial teardrops and some of those

Time: 2320.68

common non-preservatives some of those

Time: 2322.54

come preserved versions those are all

Time: 2324.7

also completely safe in the to use in

Time: 2326.74

the eye and there you can you know you

Time: 2328.48

can sort of Spritz into your eye you

Time: 2330.339

know hold the lid open and give it a

Time: 2332.02

little Spritz if you feel like you've

Time: 2333.82

got something in your eye a piece of

Time: 2335.38

dirt or A Lash that's not coming out

Time: 2337.18

just to rinse it but but having like a

Time: 2339.82

regular routine you know you're not

Time: 2342.579

going to hurt anything with the

Time: 2344.02

occasional eye rubbing we all do these

Time: 2346.119

things just kind of as a you know even a

Time: 2348.16

nervous habit or just absent-mindedly

Time: 2350.8

you know you might you know scratch your

Time: 2352.72

arm or rub your eyes or things like that

Time: 2354.7

that's fine you're not going to hurt

Time: 2356.02

anything there are conditions where

Time: 2358.78

people sort of develop kind of a almost

Time: 2361.359

like a psychological habit there are

Time: 2363.7

certain conditions where people actually

Time: 2365.02

do too much eye rubbing it can be

Time: 2367.3

dangerous if you're in that group but

Time: 2368.859

for the regular run-of-the-mill every

Time: 2371.44

day occasional I rubbing fine if you

Time: 2374.32

certainly if you get a lash in there and

Time: 2375.82

you're trying to rub it and blink it and

Time: 2377.619

tear it out and again in that situation

Time: 2380.32

you can use some artificial tears

Time: 2382.72

wedding drops saline drops those would

Time: 2385.839

be the way to do it what an incredible

Time: 2387.64

tissue the way you describe it you know

Time: 2390.04

the self-cleaning and yet so delicate

Time: 2393.52

a piece of the brain literally lining

Time: 2395.98

the back of each of our eyes like like a

Time: 2398.14

pie crust I mean it's a really

Time: 2399.82

remarkable

Time: 2401.38

um biological system of course I don't

Time: 2403.359

have to tell you that it's just it it

Time: 2405.339

never ceases to to amaze me

Time: 2408.339

let's talk about eye exams in adults

Time: 2410.8

so

Time: 2412.78

people are aware presumably that they're

Time: 2415.14

optometrists and ophthalmologists I

Time: 2417.28

think it's important that we Define

Time: 2418.599

their different and also overlapping

Time: 2420.64

roles and

Time: 2423.16

for those that you know are past High

Time: 2425.14

School age probably not getting eye

Time: 2426.82

exams unless they're sensing a problem

Time: 2429.24

perhaps not even with blurry vision or

Time: 2432.119

difficulty seeing at a distance but

Time: 2434.92

sometimes just what feels like fatigue

Time: 2437.079

of the eyes or a hard time maintaining

Time: 2439.119

alignment of the eyes

Time: 2441.22

um so how often do you recommend people

Time: 2442.96

get eye exams what is a true regular eye

Time: 2445.42

exam and is it important that people go

Time: 2447.94

to an ophthalmologist or will an

Time: 2449.5

optometrist suffice typically

Time: 2451.24

optometrists are a little bit easier for

Time: 2453.099

most people to access because there's

Time: 2454.599

usually one someplace near an eyeglass

Time: 2456.82

store so what are their roles how often

Time: 2459.82

should we get our eyes checked yeah

Time: 2462.7

um optometrists and ophthalmologists do

Time: 2464.68

have very overlapping roles in being Eye

Time: 2468.099

Care Providers there are something over

Time: 2470.92

40 or 50 000 optometrists in the United

Time: 2473.44

States or somewhere around 20 000

Time: 2476.4

ophthalmologists in the United States

Time: 2478.74

optometrists get an optometry degree

Time: 2481.119

they often have OD after their name

Time: 2484.38

ophthalmologists usually went you know

Time: 2486.4

went to medical school so they either

Time: 2488.2

have an MD after their name or they kind

Time: 2490.839

of a do version of a medical degree and

Time: 2494.38

uh and then optometrists will have done

Time: 2496.359

additional clinical training in that

Time: 2498.28

area in their area of Eye Care provision

Time: 2501.42

ophthalmologist MD doctor

Time: 2503.5

ophthalmologist Eye Care providers in

Time: 2506.38

addition to that training will have done

Time: 2508.26

surgical training in Ophthalmology

Time: 2512.26

um now there's a lot of overlap and

Time: 2516.46

um in both scenarios uh you can be

Time: 2519.579

getting your sort of General exam taken

Time: 2521.619

care of maybe a screening exam I think

Time: 2524.68

that there's been a traditional

Time: 2526.18

differentiation between optometrists and

Time: 2529.42

ophthalmologists with optometrists

Time: 2531.28

providing a little more of the primary

Time: 2534.28

care eye screening maybe managing early

Time: 2538.42

disease common diseases as well with

Time: 2542.619

more advanced disease often sort of

Time: 2544.9

upgrading to perhaps specialist

Time: 2547.5

ophthalmologists in those areas but that

Time: 2551.2

distinction has been declining over time

Time: 2554.26

it's still true that in I think most if

Time: 2556.78

not all states only the MD

Time: 2558.78

ophthalmologists surgeons can do eye

Time: 2561.339

surgeries but both both groups of eye

Time: 2565.3

care providers can diagnose both can

Time: 2568.38

prescribe appropriate eye drop

Time: 2571.24

treatments including prescription eye

Time: 2573.16

drop treatments for for many of our

Time: 2575.32

diseases eye diseases

Time: 2578.56

and um and in some states

Time: 2581.7

optometrists have successfully lobbied

Time: 2584.2

for uh sort of expanded rights of

Time: 2586.599

providing Air Care Eye Care and again

Time: 2589.72

um access to care for you know the

Time: 2592.66

regular person wherever they may live is

Time: 2595.24

is the most important element and so

Time: 2598.18

being able to access eye care whether

Time: 2600.579

it's with an optometrist in your

Time: 2602.44

community or an ophthalmologist that may

Time: 2604.72

be in your community or maybe at a

Time: 2606.339

distance I think that's the the really

Time: 2608.319

important thing is to access care now

Time: 2610.66

kind of like we were talking about with

Time: 2612.099

kids uh if you're in your teens 20s

Time: 2615.88

maybe even 30s and not having any

Time: 2618.76

problem you've got no complaints you can

Time: 2621.4

see a distance you can see it near

Time: 2624.579

um you know so you can read without

Time: 2625.72

classes you can drive without classes

Time: 2629.5

um you're not having any eye pains you

Time: 2631.96

know pains around the eyes you know

Time: 2634.72

redness of the eyes you may never

Time: 2637.119

present to an eye care provider through

Time: 2640.72

the first four Decades of life

Time: 2642.819

and almost all the time it's going to be

Time: 2646.78

okay right if you're not symptomatic the

Time: 2649.42

chance you've got some terrible lurking

Time: 2651.64

disease in there is low

Time: 2655

but we do wish that we had a little more

Time: 2658.3

screening going on because there are

Time: 2660.16

some diseases glaucoma for example my

Time: 2662.8

specialty the two main risk factors for

Time: 2665.619

glaucoma are increasing age and that

Time: 2668.74

usually presents you know in most cases

Time: 2670.48

actually after age 40 but also

Time: 2673.06

increasing eye pressure and if your eye

Time: 2675.46

pressure is too high you can't feel that

Time: 2677.74

that won't feel funny to you if it sort

Time: 2679.9

of slowly is crept up over the years and

Time: 2682.54

so from a screening perspective it is

Time: 2684.76

good to get some kind of screening exam

Time: 2688.18

could be at a public health fair could

Time: 2690.28

be that you go into the local

Time: 2691.839

optometrist just say hey I've never been

Time: 2694.42

checked I'd like to be checked once make

Time: 2696.16

sure everything's good could you ask for

Time: 2697.78

sorry to interpret could somebody say

Time: 2699.28

I'd like my pressures checked as I

Time: 2701.02

recall the optometrist they're going to

Time: 2702.339

do a puff test so they're going to blast

Time: 2703.839

some air get a sense of how how rigid or

Time: 2706.66

or soft again using non-clinical

Time: 2709.839

non-technical language here the eyeball

Time: 2711.94

happens to be

Time: 2713.26

um not right now by the way I'm sure

Time: 2714.64

there are are several hundreds of

Time: 2716.5

thousands of people who are with eyes

Time: 2718.42

closed touching the sides of their

Time: 2719.56

eyeballs and I'm only half joking please

Time: 2721.72

don't do this folks I'm given the

Time: 2723.52

conversation we just had about eye

Time: 2724.78

cleanliness and eye rubbing but my

Time: 2726.579

understanding is that the old fat truly

Time: 2728.56

old-fashioned eye pressure exam was you

Time: 2731.14

would close your eyes and the

Time: 2732.52

ophthalmologist would gently press to

Time: 2735.46

see whether or not your eyes were more

Time: 2737.02

rigid than last time yeah is that right

Time: 2738.94

yeah that's called ballot mint and you

Time: 2740.74

can kind of you can you can kind of just

Time: 2742.78

take one second if you're listening and

Time: 2744.819

press on your eyes just very lightly and

Time: 2746.619

you there's a little give of course the

Time: 2748.24

eyelids part of that give but but it's

Time: 2750.04

not it's not like rock hard and if we

Time: 2752.859

press and it feels under the eyelid like

Time: 2755.319

gosh something under there is a rock

Time: 2757.119

hard then we know something is wrong

Time: 2759.099

that is way too high pressure if it's

Time: 2761.68

raw card but I'll tell you our ability

Time: 2763.66

to differentiate the fine points of eye

Time: 2765.7

pressure other than Rock Hard or not

Time: 2769.3

rock hard is pretty limited so yeah the

Time: 2772.42

optometrist office or the

Time: 2774.16

ophthalmologist office office as part of

Time: 2776.02

a comprehensive screening exam they'll

Time: 2778.359

check the eye pressure they'll look at

Time: 2780.339

the surface of your eyes make sure

Time: 2781.839

everything's looking healthy there

Time: 2783.04

including the eyelids and lashes and

Time: 2785.26

they'll look inside the eye and be able

Time: 2786.76

to screen for these diseases that way

Time: 2788.619

too in addition to checking if you're

Time: 2790.839

complaining of any you know blurriness

Time: 2792.88

at distance or at near now after age 40

Time: 2796.78

or so a lot of people will present to an

Time: 2800.38

eye care provider because we all get

Time: 2802.96

what's called presbyopia and presbyopia

Time: 2806.2

just translates to disease a vision of

Time: 2810.16

the agent so you know myopia is our word

Time: 2813.04

for nearsighted hyperopia is farsighted

Time: 2816.64

actually amatropia means normal sighted

Time: 2819.339

so I can see it distance without any

Time: 2820.96

glasses I'm amitropic

Time: 2823.78

but then we all get presbyopia and as we

Time: 2827.2

age the lens inside our eye that's

Time: 2830.26

helping focus light onto our retina gets

Time: 2833.56

stiffer

Time: 2834.7

such that our eye muscles are no longer

Time: 2837.339

able to relax and reshape that lens and

Time: 2840.52

we're not as good as we age at

Time: 2843.78

moving our Focus from distance Vision

Time: 2846.64

distance Vision by the way is basically

Time: 2848.079

anything three feet or further away

Time: 2850.119

You're basically viewing light rays

Time: 2853.3

coming from Infinity once you're past

Time: 2855.16

three feet so three feet or further

Time: 2858.16

being able to focus that into 14 inches

Time: 2860.98

or 12 inches which might be a normal

Time: 2862.72

comfortable reading space for you

Time: 2865.96

we lose that ability to flex our lens

Time: 2868.78

relax our lens uh refocus our lens from

Time: 2872.26

distance to near and most people around

Time: 2875.14

age 40 could be a couple years before

Time: 2877.54

could be five or ten years later that

Time: 2879.64

you notice it but sort of around that

Time: 2881.5

time you start needing reading glasses

Time: 2884.38

you need a little extra even if you can

Time: 2886.48

see fine at distance and don't need

Time: 2888.22

prescription glasses for distance you

Time: 2890.68

need a booster you need reading glasses

Time: 2892.599

for near I don't know if you're

Time: 2893.92

experiencing this yet and yeah I'm

Time: 2896.02

really intrigued by this but maybe you

Time: 2898.839

could clarify when you say reading

Time: 2900.52

glasses do you mean just a magnifier

Time: 2902.319

because I use a you know a 0.5 or a 0.75

Time: 2905.74

magnifier for reading but I try and rely

Time: 2908.38

on them

Time: 2909.339

as little as possible and I want to get

Time: 2911.38

to this about using glasses as a crutch

Time: 2913.96

and the problems with that I have a

Time: 2916.18

story about that too you know it's no

Time: 2918.819

coincidence I decided to work on Vision

Time: 2920.26

I mean after all

Time: 2922.119

um I had a bunch of vision issues that

Time: 2924.099

fortunately are corrected but you know I

Time: 2927.52

I do experience for instance when I wake

Time: 2929.38

up in the morning if I look at my phone

Time: 2931.18

which by the way folks I try and get

Time: 2933.22

outside and see sunlight first before

Time: 2934.66

ever looking at the phone but I'll

Time: 2937.3

notice when I first look at my phone in

Time: 2940.3

the morning that I can see it very

Time: 2942.099

clearly through my right eye but that if

Time: 2944.2

I cover my right eye my left eye is

Time: 2946.06

extremely blurry to the point where I'm

Time: 2947.619

like oh I'm calling Jeff you know I'm

Time: 2949.3

I'm afraid but then over the course of

Time: 2951.28

maybe 10-15 minutes it resolves and I

Time: 2953.8

don't think it's because something's in

Time: 2955.119

my eye I don't think it's pressure of

Time: 2957.099

having slept on that side I don't think

Time: 2958.48

it's a lubrication of the eye issue

Time: 2961.42

um but the two eyes seem to come into

Time: 2963.819

Focus so to speak um at different rates

Time: 2966.819

early in the day and if I pop my readers

Time: 2969.4

on I can see right away so I will use

Time: 2971.92

readers late in the day often

Time: 2974.44

um if I want to read at night or

Time: 2975.819

something that's right just it feels so

Time: 2977.079

much more relaxing I feel like like I

Time: 2979.18

can finally relax whereas otherwise I

Time: 2981.64

realize that I'm straining in order to

Time: 2983.2

see does is there any um clinical

Time: 2985.18

clinical data and what I just described

Time: 2987.16

yeah you know Andy I'll tell you my

Time: 2990.099

story that's like that and

Time: 2992.68

um we were living down in San Diego when

Time: 2995.079

you and I were both professors at UC San

Time: 2997.119

Diego

Time: 2997.92

and uh we had moved into a house and I

Time: 3002.099

found a pair of glasses a pair of

Time: 3004.2

reading glasses uh in a closet and you

Time: 3007.44

know we asked around you know did any of

Time: 3009.48

the grandparents uh leave some glasses

Time: 3011.76

behind nobody seemed to know who they

Time: 3013.619

were so we finally just decided like

Time: 3015.359

well I guess the people who moved out of

Time: 3017.4

the house just left a pair of glasses

Time: 3019.02

you know in this in the back of this

Time: 3020.4

closet

Time: 3021.839

and then I tried the glasses on

Time: 3024.48

and I looked at my phone up close and

Time: 3027.48

was just like oh my God wait a second I

Time: 3030.839

didn't realize how blurry my near Vision

Time: 3033.78

was and this is back I was about 40 42

Time: 3036.18

something like that so

Time: 3038.46

so I didn't even realize until I put on

Time: 3041.7

the readers and these were

Time: 3043.44

you know 1.25 magnifiers you know so

Time: 3046.92

awesome yeah

Time: 3049.16

and I'll tell you

Time: 3052.02

I got addicted because who doesn't like

Time: 3055.38

good Vision right right I mean oh my God

Time: 3057.9

now I can make the type smaller on my

Time: 3060.18

phone I can you know it was wonderful

Time: 3062.16

and you can relax a bit I mean the

Time: 3064.2

musculature that's responsible for for

Time: 3066.24

moving the lens and focusing the eye and

Time: 3067.92

then all this extraocular musculature

Time: 3069.9

and we forgot I mean I'm definitely

Time: 3071.04

going crow's feet

Time: 3072.9

um around my eyes uh probably because I

Time: 3076.5

you know squint or something but you

Time: 3078.3

know just the ability to relax one's

Time: 3080.099

face it just feels like you know more

Time: 3082.319

more energy I feel like can be devoted

Time: 3084.119

to what we're actually looking at yeah

Time: 3085.44

we're not making light of this yeah well

Time: 3087.48

pretty soon I just kept that one pair of

Time: 3090.119

glasses with me all the time and I would

Time: 3092.339

just keep them in a pocket and whip them

Time: 3094.079

out whenever I was you know working at

Time: 3095.819

near using my phone at a little greater

Time: 3098.16

distance like a typical computer

Time: 3099.48

distance I could still see the computer

Time: 3101.099

fine so it really started for like kind

Time: 3102.9

of that close-up phone it was it was I

Time: 3105.119

could get into here but not all the way

Time: 3107.099

into here

Time: 3108.48

and um yeah and then pretty soon I was

Time: 3111.72

just totally addicted and so you know

Time: 3114.42

then I had to go buy 10 pairs and leave

Time: 3117.72

them one by the bedside table you know

Time: 3120.359

one in the car one in the computer bag

Time: 3122.28

one on everything I work at yeah because

Time: 3125.099

I'd leave them anywhere and forget them

Time: 3127.64

yeah exactly you know yeah

Time: 3130.619

so

Time: 3132.119

um yeah so

Time: 3134.099

whether using the readers

Time: 3138.2

accelerates the progression of

Time: 3142.76

dependence on the readers is still uh

Time: 3147.78

not you know that's still up for debate

Time: 3149.4

you know some studies say maybe yeah

Time: 3151.14

some studies say maybe no but certainly

Time: 3154.099

psychologically we get addicted to good

Time: 3157.559

easy vision and if you don't have to

Time: 3159.9

squint and if you're not straining your

Time: 3162

muscles and all of a sudden the text on

Time: 3164.28

your phone looks crisper again uh boy

Time: 3167.52

that's addictive you're gonna like good

Time: 3169.559

vision and so it feels like you're

Time: 3171.599

getting dependent and how much of that

Time: 3173.339

is changing the eye muscles and how much

Time: 3175.68

of that is just the psychology of

Time: 3177.24

wanting to have good Vision I think

Time: 3179.22

probably the jury's a little bit out on

Time: 3180.72

that point but point being you're either

Time: 3183.059

either way your dependence will grow and

Time: 3186.18

as you continue to age 40s 50s up until

Time: 3189.18

about 60 65.

Time: 3192.54

the ability to shape that lens gets

Time: 3195.3

weaker and weaker and weaker and so you

Time: 3198.359

need to move from the 0.5 to the 1.0 to

Time: 3201.96

the 1.5s and to the coke bottle to the

Time: 3205.26

code well thankfully not you eventually

Time: 3207.48

max out at about plus 2.5 or plus three

Time: 3211.2

because that's the amount of extra

Time: 3214.28

refractive power that you need in

Time: 3216.359

magnifiers to take the equivalent of

Time: 3219.78

your Infinity viewing and bring it up to

Time: 3222.78

14 inches to read it near basically you

Time: 3225.359

need a plus three and then you don't

Time: 3226.98

need any

Time: 3229.22

lens eye muscle action whatsoever so you

Time: 3234.18

kind of max out around 2.5S or threes

Time: 3237.48

so because most people will hit this

Time: 3241.92

somewhere in their 40s this sort of like

Time: 3243.839

gosh I'm having trouble on the phone

Time: 3246.18

I think most people actually use that

Time: 3248.4

that's like kind of the first time for a

Time: 3250.5

lot of people they're like well I guess

Time: 3252.119

I should go to the eye office right see

Time: 3254.04

the optometrist or maybe ophthalmologist

Time: 3255.96

and when they go in they should be

Time: 3258.72

getting the standard in either of those

Time: 3260.52

offices will be to give you a full

Time: 3263.099

screening exam including maybe it's the

Time: 3266.099

puff test or a blue light test or a

Time: 3268.14

little pen that can check your eye

Time: 3269.819

pressure and having a look inside and

Time: 3272.28

seeing if you're retina optic nerve look

Time: 3274.079

healthy it's kind of screening for all

Time: 3276.18

the main diseases and so and they'll

Time: 3279

tell you at that point hey you look

Time: 3281.04

great if you feel like your glasses

Time: 3283.2

aren't doing it for you in a year or

Time: 3284.88

three years come back or they might say

Time: 3287.22

hey I've detected something I'm worried

Time: 3289.14

about you and they'll set up a routine

Time: 3291.48

for your ongoing Eye Care

Time: 3294.66

assuming that somebody doesn't have

Time: 3297.3

um you know some form of amblyopia or

Time: 3300.18

the need for some a really robust

Time: 3302.339

corrective lenses

Time: 3304.859

and they are already using readers let's

Time: 3307.8

say a plus one

Time: 3310.44

or so you know plus one plus or minus

Time: 3312.359

0.5 reader

Time: 3314.22

would you recommend based on my

Time: 3316.079

experience and based on your experience

Time: 3317.76

that people strive to avoid using them

Time: 3320.7

for as long as they can because in some

Time: 3323.28

sense if that's the recommendation then

Time: 3326.4

the recommendation is that people kind

Time: 3327.839

of deal with the fact that they're

Time: 3328.92

seeing a little less well or a lot less

Time: 3330.48

well than they possibly could so I'm

Time: 3331.859

assuming that people can still drive

Time: 3333.18

well people can still read but it

Time: 3335.4

involves a little bit more effort in

Time: 3336.42

other words are we weakening Our Eyes by

Time: 3338.4

using these these readers I I realize

Time: 3340.68

you said that the data are a little bit

Time: 3341.94

mixed but as long as one can perform

Time: 3344.76

their required daily activities would we

Time: 3347.52

be better off

Time: 3348.98

delaying the use of readers

Time: 3351.54

there's two important answers to that

Time: 3354.3

question one is regarding the lens and

Time: 3358.5

the eye muscles that control the lens

Time: 3360.66

and it's entirely plausible that's what

Time: 3363.359

I was saying kind of the data is mixed

Time: 3364.8

on but it's plausible that if we would

Time: 3366.72

just exercise like work a little harder

Time: 3369.66

kind of not use as strong a reader as we

Time: 3372.839

want or not use that reader as often as

Time: 3375.66

we might really enjoy uh are we

Time: 3378.72

exercising those muscles and kind of

Time: 3380.819

exercising the ability to to stretch

Time: 3383.76

versus relax the lens and kind of slow

Time: 3387

the progression from the 1.0 reader to

Time: 3391.14

the 1.25 reader to the 1.5 reader Etc

Time: 3394.619

right and so that that's why I'm saying

Time: 3396.599

the data is mixed but there's a good

Time: 3398.04

premise that maybe if you're exercising

Time: 3400.079

but let me give you the on on the other

Time: 3402.48

hand it's probably ideal

Time: 3406.02

to give your retina and your brain the

Time: 3410.339

sharpest visual signals you can

Time: 3413.88

so why hamstring your retina and your

Time: 3418.8

brain and your vision and your enjoyment

Time: 3421.619

and ability to read or do near work by

Time: 3425.16

constantly undercutting the the reading

Time: 3428.7

glasses or leaving them out or you're

Time: 3432.3

not helping the whole back part of yours

Time: 3435.42

maybe you're maybe you're helping the

Time: 3437.16

lens but you're definitely not helping

Time: 3439.559

your retina and brain by feeding it

Time: 3441.72

blurry information all of that time so I

Time: 3445.98

actually think just give in use the

Time: 3449.46

readers have your enjoy your Best Vision

Time: 3452.9

all the time and if that means wearing

Time: 3455.76

glasses and by the way if that means

Time: 3457.8

that you're going to have minus two

Time: 3459.78

glasses for vision and you'll eventually

Time: 3461.7

need minus 250s for distance Vision or

Time: 3465.18

if you're going to need readers 1.5

Time: 3467.64

readers now and in a few years 2.0

Time: 3470.22

readers okay so you'll get the next

Time: 3473.04

reader it's it's it's actually not a big

Time: 3475.14

deal you can you can you know you're not

Time: 3477.42

you're not hurting you're probably

Time: 3479.76

helping and in the meantime it's an

Time: 3482.4

enormous enjoyment to actually have good

Time: 3484.5

Vision all the time right so so I

Time: 3487.38

actually counsel people

Time: 3489.599

just wear the glasses that work best for

Time: 3491.579

you you know you're only minimally

Time: 3493.619

changing how your prescription is going

Time: 3496.079

to change over time very minimally so

Time: 3498.96

just enjoy your Best Vision even if it's

Time: 3502.079

using readers for clothes or

Time: 3503.579

prescription glasses for far

Time: 3506.099

I appreciate that recommendation I do

Time: 3508.44

enjoy you using the readers at night it

Time: 3510.839

really helps for all the reasons I

Time: 3512.76

mentioned before

Time: 3515.04

I've noticed that driving at night

Time: 3517.079

presents an enormous strain on my visual

Time: 3519.599

system and I've noticed this for a

Time: 3520.98

number of years are there any I know

Time: 3523.079

there's something called stationary

Time: 3524.16

night blindness I don't think I'm

Time: 3525.66

stationary night blind

Time: 3527.819

um I think the mutation for stationary

Time: 3529.5

night blindness was identified in the

Time: 3531.96

Colusa horse or something like that

Time: 3533.64

these were horses that you could walk up

Time: 3534.96

to very easily and they wouldn't even

Time: 3536.16

see you until you're right there

Time: 3537.18

someone's going to correct me on this

Time: 3538.44

it's the internet but I think that the

Time: 3540.66

mutation was identified

Time: 3542.76

um Etc but I don't think I'm stationary

Time: 3544.38

night blind but I do find that driving

Time: 3546.18

at night I get very fatigued and then

Time: 3550.02

I'll sometimes even wear my plus one

Time: 3551.94

readers when I drive at night which

Time: 3555

removes the fatigue even though I'm

Time: 3557.22

looking more or less at a distance are

Time: 3559.14

there some conditions that make it hard

Time: 3560.579

for people to see at night for which

Time: 3562.74

they would want corrective lenses

Time: 3565.619

um and what what sorts of biology

Time: 3567.78

underlies that assuming that somebody is

Time: 3570.119

not stationary night blind or a Colusa I

Time: 3573.119

think is the name of the breed horse

Time: 3575.4

yeah that's a great question you know we

Time: 3578.099

for the for the optical defects in our

Time: 3581.46

eyes most or many of which can be

Time: 3584.28

corrected with just having the right

Time: 3585.839

prescription lenses we can get away with

Time: 3589.26

it without using those Corrections in

Time: 3592.14

brighter light

Time: 3593.46

and so during the daytime

Time: 3596.88

um you know you could be slightly blurry

Time: 3599.64

you know if I have a real bright light

Time: 3602.059

uh and a good high contrast book you

Time: 3605.04

know with black letters on the white

Time: 3606.599

page I can get away with reading that

Time: 3608.819

without my readers unlike if if I'm in

Time: 3612.119

dim light then I feel and that might be

Time: 3613.68

kind of what you're describing if you're

Time: 3615

reading at night you actually prefer to

Time: 3616.98

use the readers a little more even at

Time: 3618.72

night because we can make up for a lot

Time: 3621.839

of that blur if we just have bright

Time: 3624

enough signal and contrast coming into

Time: 3626.4

our eyes makes sense yeah so when you're

Time: 3629.339

driving at night and noticing this this

Time: 3631.619

might be revealing a little bit of a

Time: 3633.96

need for glasses now I'm not suggesting

Time: 3636.9

this is the answer but far more common

Time: 3639.66

than having congenital stationary night

Time: 3642.359

blindness would be being what's called a

Time: 3645.48

latent hyper rope okay now we talked

Time: 3649.14

about already how the lens inside our

Time: 3651.48

eye goes from focusing it distance to

Time: 3654.42

then we squeeze the muscles the lens

Time: 3656.16

actually rounds up and allows us to

Time: 3658.02

focus it near

Time: 3659.4

some people's Optical system of their

Time: 3662.04

eye is actually wired or designed or

Time: 3665.94

sort of set up in length not for regular

Time: 3669.299

distance which would be anywhere from

Time: 3670.859

about three feet to Infinity

Time: 3673.2

but it's actually designed it's actually

Time: 3675.299

tuned for being beyond Infinity which

Time: 3678.72

doesn't make any actual sense when you

Time: 3680.64

talk about it but just the Optics of the

Time: 3682.5

eye at their best Focus are actually

Time: 3684.72

focusing the light behind the retina and

Time: 3687.839

and if you're doing that when you're

Time: 3690.119

younger you're actually using some of

Time: 3692.28

your focusing power to to use those

Time: 3695.88

muscles strain those muscles relax that

Time: 3698.04

lens round up that lens and have your

Time: 3701.579

vision Focus From Beyond Infinity to

Time: 3705.66

normal distance like distance vision and

Time: 3709.14

so if you're a latent hyperope you are

Time: 3711

constantly using those muscles and again

Time: 3714.059

if you're tired it's the end of the day

Time: 3716.4

your muscles are feeling a little

Time: 3717.96

fatigued uh your latent hyperopia or by

Time: 3722.4

the way if you've had a drink or two

Time: 3724.64

alcohol can do this too your latent

Time: 3727.98

hyperopia can kind of kick in especially

Time: 3730.559

as we're age and we're not as good at

Time: 3732.599

refocusing that lens anyway and now all

Time: 3735.66

of a sudden your vision is kind of

Time: 3738.72

reverting to its natural state which is

Time: 3741.42

slightly out of focus at distance

Time: 3743.28

because it's actually focused beyond

Time: 3745.559

Infinity if you will and so all of a

Time: 3748.559

sudden you put on that plus one just for

Time: 3750.24

a little extra booster kick and you're

Time: 3751.92

like oh yeah yeah distance vision is

Time: 3753.66

clean and easy now so

Time: 3755.94

I'll have to bring you into the clinic

Time: 3757.559

to really be sure but you could be

Time: 3759.839

exhibiting a little bit of that kind of

Time: 3761.579

latent hyperopia I definitely want the

Time: 3764.16

eye exam and I want it from you and I've

Time: 3765.78

been called a lot of things in life um

Time: 3767.64

and we can now let add perhaps latent

Time: 3770.7

hyper

Time: 3771.9

opiate

Time: 3773.18

uh to that

Time: 3775.559

I'd like to take a quick break and thank

Time: 3777.54

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Time: 3783.359

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Time: 3785.16

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your health goals I've long been a

Time: 3788.76

believer in getting regular blood work

Time: 3790.079

done for the simple reason that many of

Time: 3792.42

the factors that impact your immediate

Time: 3793.799

and long-term Health can only be

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assessed with a quality blood test the

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problem with a lot of blood and DNA

Time: 3798.9

tests out there however is that they'll

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give you information about certain lipid

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markers or hormone markers but no

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information about what to do with all of

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that data inside tracker makes it very

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easy to look at your levels of hormones

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metabolic factors lipids Etc and then to

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assess what sorts of Behavioral

Time: 3815.579

nutritional supplementation or perhaps

Time: 3817.38

other interventions you might want to

Time: 3818.819

use to bring those numbers into the

Time: 3821.4

ranges that are appropriate and indeed

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optimal for you if you'd like to try

Time: 3825.119

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insidetracker.com huberman and get 20

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off any of inside tracker's plans that's

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inside tracker.com huberman to get 20

Time: 3834.119

off another easier and again this

Time: 3837.66

discussion is not designed to be an eye

Time: 3839.28

exam for me but I have yet another

Time: 3841.619

experience that I think illustrates the

Time: 3844.44

key importance of both critical period

Time: 3846.599

plasticity and the questions about

Time: 3849.599

whether or not to rely on corrective

Time: 3851.04

lenses and that is from the time I was

Time: 3853.799

pretty young I could make my sister

Time: 3854.94

laugh by deviating one eye inward so not

Time: 3857.52

crossing my eyes but moving one eye

Time: 3859.079

Inward and then what happened was when I

Time: 3861.299

was in college and studying a lot a lot

Time: 3864.66

and getting very fatigued I noticed that

Time: 3866.4

this I started just kind of drifting a

Time: 3868.079

little bit so I went to the campus

Time: 3871.02

Health Center and they gave me a

Time: 3873.299

prescription for a prism lens which of

Time: 3876.059

course redirects the image but then I

Time: 3878.099

noticed that this eyeball moving Inward

Time: 3880.68

and I guess for those of you watching on

Time: 3882.299

uh on YouTube and not just listening um

Time: 3884.819

I can do this

Time: 3886.14

um by just moving one eye in all right

Time: 3888.299

as I can move this side yeah it's a

Time: 3890.28

fairly pronounced it started to really

Time: 3891.48

drift in at a relaxation State and I

Time: 3894.18

started seeing double again so I thought

Time: 3895.559

whoa these prism this one prism lens is

Time: 3899.22

a crutch of the sort that I really don't

Time: 3900.66

want crushed the glasses it broke them

Time: 3903.059

and it never went back to them

Time: 3905.819

um I have voluntary control over it but

Time: 3907.98

that's one example where the corrective

Time: 3910.44

lens can actually create a pretty

Time: 3912.18

significant shift in eye position if one

Time: 3914.94

relies on it so this gets back to this

Time: 3917.04

issue of

Time: 3918.42

um when should people Force themselves

Time: 3920.4

to work with their natural vision maybe

Time: 3923.22

do some more far viewing

Time: 3925.38

um as opposed and certainly get outside

Time: 3926.94

and get sunlight into the sunlight full

Time: 3928.92

spectrum light as opposed to relying on

Time: 3930.96

active lenses yeah and and you've raised

Time: 3933.96

a very important distinction here and

Time: 3936.54

that's the distinction between the

Time: 3938.28

muscles that are inside our eye that we

Time: 3941.16

use to relax and refocus the lens and

Time: 3944.16

the muscles that are on the outside of

Time: 3945.9

the eyeball of course inside our orbit

Time: 3948

but on the outside of the eyeball that

Time: 3949.74

turn the eyes and if everything's

Time: 3952.319

working right keeps our eyes really

Time: 3954.18

yoked straight and we talked about

Time: 3956.099

earlier uh this possibility that you may

Time: 3958.98

have been having a little bit of

Time: 3960.359

intermittent esotropia or intermittent

Time: 3963.299

turning in of the eyes that then

Time: 3965.76

culminated on that day of a day at the

Time: 3967.799

pool when you really noticed it

Time: 3969.74

and your ongoing ability to actually

Time: 3972.78

turn one eye in could be related to that

Time: 3975.18

I remember as a kid standing in front of

Time: 3977.22

the mirror and I I couldn't get my eyes

Time: 3979.02

to cross even though friends could do it

Time: 3981.059

and you know so you know I I was in the

Time: 3983.64

losing group on that on that end you

Time: 3985.92

became an ophthalmologist and then I

Time: 3987.24

became an ophthalmologist and I must say

Time: 3988.98

it is very reassuring that you have

Time: 3990.539

excellent Vision you know I always worry

Time: 3992.16

when I go to a new dentist and then I

Time: 3993.839

look up at them in one moment and if

Time: 3995.46

they're not wearing a mask that their

Time: 3996.66

teeth are not you know pristine I think

Time: 3998.579

well what am I doing here so at you know

Time: 4000.68

an ophthalmologist with excellent Vision

Time: 4002.42

brings me uh great comfort the toddler's

Time: 4005.24

children should have shoes right exactly

Time: 4008.299

um but yeah so so when to correct when

Time: 4011

not to correct with lenses and I realize

Time: 4013.099

here we haven't talked at all about

Time: 4014.18

contacts we've been talking about

Time: 4015.819

eyeglasses yeah let's come to contacts

Time: 4018.26

in a sec if you want but yeah let me

Time: 4020.539

return to your question the difference

Time: 4022.52

between providing corrective lenses that

Time: 4025.94

allow you to focus for near or distance

Time: 4028.72

uh in your glasses so that you can go

Time: 4032.66

easy on the inside the eye eye muscle

Time: 4035.24

having to work so hard a lot of people

Time: 4036.98

get eye strain and sort of uh headaches

Time: 4039.2

even from that from not having adequate

Time: 4041.9

correction that they're wearing that's

Time: 4044.18

different actually especially when we're

Time: 4046.4

children or again into that maybe even

Time: 4048.44

into the teens and even young adult

Time: 4050

years

Time: 4051.26

from the eye muscles on the outside of

Time: 4053.48

the eyes which are supposed to be yoking

Time: 4055.22

our eyes straight and so that you have

Time: 4057.079

them both looking at the same point in

Time: 4058.88

space and and there it's actually quite

Time: 4062.24

a common treatment to try to under

Time: 4064.94

correct and ask people to exercise and

Time: 4068.9

not just give a prism that says hey if

Time: 4071.66

your eyes in sometime we'll use a prism

Time: 4073.579

so the light sort of looks right to you

Time: 4075.619

but rather under correct that and sort

Time: 4078.38

of really force you to exercise trying

Time: 4081.5

to yoke your two eyes straight together

Time: 4083.78

and so that's that's in contrast and

Time: 4086.42

they're actually I think many

Time: 4088.339

optometrists who often specialize in in

Time: 4091.16

what are the right glasses to give in a

Time: 4093.559

situation like that wherever possible

Time: 4096.759

especially during

Time: 4099.08

uh development as our bodies are

Time: 4101.42

developing as we're sort of growing in

Time: 4103.04

our younger years uh take the approach

Time: 4106.4

of intentionally trying to under correct

Time: 4108.92

not use a prism or not use a full prism

Time: 4111.98

correction uh and um to really help uh

Time: 4116.779

sometimes it's also like an

Time: 4118.1

accommodative reflex that your eyes are

Time: 4120.02

just you're spending so much time

Time: 4121.219

reading it near when you read it near

Time: 4123.5

your eyes actually naturally turn in a

Time: 4125.779

little bit to focus uh at that nearer so

Time: 4128.359

that they can be looking at the same

Time: 4130.16

word on the page and that can also if

Time: 4133.16

you've got kind of too much muscle drive

Time: 4135.08

you can overshoot that and so sometimes

Time: 4137.719

just using not a prism but like a little

Time: 4140

bit of a plus lens in kids just so they

Time: 4142.339

don't have to work quite so hard to turn

Time: 4144.319

their eyes in and sort of over exercise

Time: 4147.259

those muscles these are all great

Time: 4149.6

examples we're going to an eye care

Time: 4151.759

provider often for these kinds of issues

Time: 4153.62

an optometrist is the right first place

Time: 4155.48

to start

Time: 4156.62

you'd like to say that every optometrist

Time: 4158.9

and every ophthalmologist is always

Time: 4160.699

going to give the exact right thing for

Time: 4162.679

for each kid or young adult or older

Time: 4164.779

adult to do and and we wish all medical

Time: 4167.359

care providers were were always right on

Time: 4169.759

Target and a lot of times it's a perfect

Time: 4172.46

science but a lot of times it's an

Time: 4173.96

imperfect science and so it could be

Time: 4176.42

that at least with you know we're now 20

Time: 4178.819

25 30 years later but like it could be

Time: 4181.16

that today that 20 year old version of

Time: 4184.64

yourself would have been given a

Time: 4186.259

different uh approach to having one eye

Time: 4189.14

intermittently occasionally turning in

Time: 4191.42

like that is there any real value to

Time: 4195.08

um near far exercises you know so-called

Time: 4197.36

pencil push-ups or a smooth Pursuit

Time: 4200.179

tracking I've talked a little bit about

Time: 4201.92

it before on the podcast but that was

Time: 4203.719

you know some time ago so what are your

Time: 4205.82

thoughts on on that is there any value

Time: 4207.8

whatsoever I mean they require a little

Time: 4209.3

bit of work just like going to the gym

Time: 4211.04

but you know you know 25 reps a day of

Time: 4214.04

near far

Time: 4215.48

um especially as one is transitioning

Time: 4216.92

from age 30 to age 50

Time: 4219.26

um is it worthwhile yeah is it harmful

Time: 4221.84

in any way definitely not harmful and

Time: 4224.48

again uh you know would it slow down or

Time: 4228.199

sort of uh slow down your progression to

Time: 4231.34

presbyopia or needing those reading

Time: 4233.6

glasses uh could be some people also

Time: 4236.239

develop

Time: 4237.44

um sort of uh you know a real failure to

Time: 4240.32

properly turn their eyes in and so they

Time: 4242.6

actually would benefit if you've been

Time: 4244.46

diagnosed with that inability or having

Time: 4246.56

double vision at near but not at

Time: 4248.6

distance

Time: 4250.34

um so that kind of convergence in

Time: 4252.46

insufficiency for example then then

Time: 4256.04

pencil push-ups off and get prescribed

Time: 4258.14

as a way to try to exercise those skills

Time: 4260.36

and you know uh in your eye muscles I

Time: 4263.659

should interrupt here and just tell

Time: 4265.04

people for those of you that are

Time: 4266

listening not watching the pencil

Time: 4267.199

push-up we can put a link to it in the

Time: 4270.14

show note caption so it's essentially

Time: 4271.4

taking a pen or pencil looking at it at

Time: 4274.28

um at arm's distance and then slowly

Time: 4276.86

moving it toward your nose and

Time: 4278.62

deliberately working hard and it is a

Time: 4281

bit of effort to continue to focus on it

Time: 4283.699

at a close distance at some point it

Time: 4285.38

will become blurry because I can't cross

Time: 4288.08

my eyes any further unless I become a

Time: 4290.659

cyclops and then moving it back out

Time: 4292.34

again and doing that for you know 10 to

Time: 4294.26

25 repetitions maybe once or twice a day

Time: 4297.14

a few times a week that's what those are

Time: 4299.96

pencil push-ups yeah yeah so

Time: 4302.78

um you're certainly not going to hurt

Time: 4303.98

anything there are other situations

Time: 4306.02

where those really do get prescribed and

Time: 4308.42

there's definitely some good clinical

Time: 4310.34

trial data suggesting that they can

Time: 4312.08

actually help for example recovery from

Time: 4314

concussion a lot of people actually

Time: 4317.12

one of the really telling ways to

Time: 4319.28

diagnose concussion and this can be

Time: 4322.04

concussion from sports or a fall or you

Time: 4324.92

know any any source of concussion your

Time: 4328.159

smooth Pursuit which is the ability

Time: 4330.08

let's say I've got a DOT moving around

Time: 4331.94

in a circle on a screen and I'm

Time: 4334.28

following that thought with my eyes my

Time: 4336.32

eyes should be able to very smoothly

Time: 4338.06

follow that circle around

Time: 4341.14

watching a hockey game is that like your

Time: 4344

body fan right like that you know just

Time: 4346.1

following a ball you know following any

Time: 4348.44

movement with smooth Pursuits of your

Time: 4350.659

eyes

Time: 4351.5

and after concussion that actually those

Time: 4354.62

systems in our brain the sort of

Time: 4356.36

reflexive ability to properly follow

Time: 4358.34

that use that visual input to tell your

Time: 4361.159

eye muscles exactly where to move

Time: 4363.44

gets disrupted and so all of a sudden

Time: 4365.42

your smooth Pursuit starts to look

Time: 4367.04

choppy it's not so smooth anymore and

Time: 4368.96

it's actually a way to diagnose and

Time: 4371.54

follow recovery from concussion and part

Time: 4375.38

of the visual rehab sort of neuro rehab

Time: 4379.1

one of the approaches being used and

Time: 4381.5

further studied still in recovery from

Time: 4384.62

concussion is actually doing those kinds

Time: 4386.84

of exercises like pencil push-ups or

Time: 4389.98

basically what you've described is

Time: 4392.06

focusing from far away to focusing near

Time: 4394.64

and doing that back and forth and using

Time: 4396.98

that to sort of like help regain uh the

Time: 4400.82

tighter control of our eye movements and

Time: 4403.46

that eye brain connection so if

Time: 4405.86

traumatic brain injury causes deficits

Time: 4408.08

in smooth Pursuit eye movements and some

Time: 4409.94

of the recovery protocols for traumatic

Time: 4412.4

brain injury are to have people do

Time: 4414.02

smooth Pursuit protocols and pencil

Time: 4415.58

push-ups are these also the sorts of

Time: 4417.8

things that anyone can just do I mean

Time: 4420.58

whenever possible we like to share tools

Time: 4424.159

for various aspects of Health on this

Time: 4426.26

podcast but of course we don't want

Time: 4428.06

people cowboying this stuff in a way

Time: 4430.28

that could be detrimental to their to

Time: 4432.14

their Vision so is it okay to get on

Time: 4434.06

YouTube and find a smooth Pursuit um

Time: 4437.719

Tool uh we can put a link to these there

Time: 4440.239

there are several of them

Time: 4441.679

um and people spend a few minutes doing

Time: 4443.12

this yeah

Time: 4444.92

you're definitely not going to hurt

Time: 4446.54

anything so totally fine to do it and

Time: 4449.42

some people may notice you know like

Time: 4451.4

they feel a little more visually active

Time: 4454.34

if they do these kinds of exercises

Time: 4457.64

um I think most people would do them and

Time: 4459.62

not notice something in their daily life

Time: 4461.9

we actually have

Time: 4464.3

um

Time: 4464.96

made so much progress you know in

Time: 4467.84

research in thinking about how do we

Time: 4470.719

take the diseased or dysfunctioning or

Time: 4474.08

aging eye and get it back to healthy and

Time: 4478.219

normal

Time: 4479.42

but there's a whole other area of

Time: 4482.48

science that's we're really just barely

Time: 4484.88

touching we've actually we've actually

Time: 4486.56

just opened a vision performance center

Time: 4490.06

to really get at not just how do we

Time: 4492.739

rehab the sick eye back to health but

Time: 4496.4

what's the difference between

Time: 4497.659

functioning normally and functioning

Time: 4500.42

above normally

Time: 4501.98

for example athletes when they get

Time: 4504.62

studied for visual Vision

Time: 4506.38

characteristics they have faster visual

Time: 4509.78

reflexes higher visual Acuity uh how

Time: 4513.92

much of that was you know genetic how

Time: 4516.14

much of that is trained we don't really

Time: 4518.06

understand could we train all of us with

Time: 4520.82

you know normal vision to get up to

Time: 4524.06

Supra normal vision these are like great

Time: 4527.3

important questions that are really

Time: 4528.92

relevant to you know every regular

Time: 4531.92

person of course you know people doing

Time: 4533.36

Esports and the gaming communities and

Time: 4536.48

athletes is part of what we're studying

Time: 4538.159

in the vision performance center but

Time: 4539.78

these are really really big

Time: 4541.699

opportunities to try to understand how

Time: 4544.04

do we move people from normal vision to

Time: 4546.5

Super normal vision and there's evidence

Time: 4548.6

that you can do it so here's a great

Time: 4550.64

example some athletes train

Time: 4553.96

using these special goggles that

Time: 4557.42

actually use electrical signals in the

Time: 4559.94

glasses part of the goggles to actually

Time: 4561.98

black out your vision one thirtieth of

Time: 4565.52

every second two thirtieths of every

Time: 4567.739

second three thirtieths of every second

Time: 4570.14

now imagine you and I are passing a

Time: 4572.3

basketball back and forth except you're

Time: 4574.699

wearing goggles and all of a sudden

Time: 4576.739

you're only getting 90 percent of the

Time: 4579.199

data of where's that basketball on its

Time: 4581.78

way to my hands now you're only getting

Time: 4583.82

eighty percent now you're only getting

Time: 4585.38

70 percent of that visual information

Time: 4587.56

and you are practicing right you are

Time: 4590.48

getting good at catching a basketball

Time: 4592.36

when you only have a fraction of the

Time: 4595.28

visual information and now I put you

Time: 4597.8

back on the basketball court without the

Time: 4599.9

goggles you might be really good at

Time: 4603.32

passing that basketball around and

Time: 4605.06

catching that basketball right and so

Time: 4607.1

the idea that we could train and

Time: 4609.8

understand the biology of training to

Time: 4612.92

get the eyes from normal to supernormal

Time: 4615.44

Performance I think it's an amazing area

Time: 4617.9

and one that we've really just started

Time: 4619.58

to dig into that's fantastic so this is

Time: 4622.46

a a new program at Stanford through the

Time: 4624.98

department of Ophthalmology is it linked

Time: 4627.26

up at all with the woosai performance

Time: 4628.88

Institute yeah actually there's been a

Time: 4631.159

lot of focus over the years I think in

Time: 4633.44

human performance and there's actually a

Time: 4635.36

new human performance uh Alliance and

Time: 4638.179

Center we've we've we've long had really

Time: 4641.12

run through the department of our

Time: 4642.32

Orthopedics a human performance

Time: 4645.199

laboratory that's really you know much

Time: 4647.36

more about joints and muscles and

Time: 4650.239

strength and conditioning and stretching

Time: 4653.38

to layer on to that now a real

Time: 4656.659

understanding of how vision is operating

Time: 4658.9

you know it's interesting let's go back

Time: 4661.82

to the example of concussion you know

Time: 4663.5

we've got I don't know about 800 Varsity

Time: 4665.719

student athletes and all the different

Time: 4667.34

sports at Stanford and you might have a

Time: 4670.28

student athlete come in and say you know

Time: 4672.08

something doesn't feel right I got a

Time: 4674.06

little hit on the head I feel like my

Time: 4676.88

vision is a little bit messed up maybe

Time: 4678.8

I've got a mild concussion you could

Time: 4681.56

imagine doing some of these tests on

Time: 4684.44

some of these performance athletes for

Time: 4686.659

example and saying well gosh you look

Time: 4689.36

normal

Time: 4690.5

but actually they used to be operating

Time: 4693.199

at a supernormal rate and this is a

Time: 4695.719

noticeable decrement for them and so

Time: 4698.6

just starting to study and understand

Time: 4700.58

what's the difference between normal and

Time: 4702.92

supernormal how do we go back and forth

Time: 4705.02

between those two how do we measure that

Time: 4706.76

difference and maybe ultimately how do

Time: 4708.62

we train into that difference I think

Time: 4710.42

it's going to be exciting and not just

Time: 4711.86

for athletes you know for for regular

Time: 4713.719

people you know you talk about driving

Time: 4715.58

at night is there a solution where we

Time: 4717.56

could train our eyes to be better at

Time: 4720.14

driving at night and I don't know maybe

Time: 4721.82

reduce the number of accidents that

Time: 4723.38

happen out in the world so well

Time: 4725.179

certainly there's

Time: 4726.38

um physical training protocols which are

Time: 4728.179

redefining what a 60 year old or 70 year

Time: 4731

old

Time: 4731.719

could look like and feel like and be

Time: 4734.12

able to perform like why not do the same

Time: 4736.52

for vision

Time: 4737.9

um so I don't think there's anything

Time: 4739.54

Supernatural or greedy about doing it I

Time: 4742.58

think that's the excitement of biology

Time: 4744.8

and neuroplasticity that you can extend

Time: 4746.719

it forward as opposed to just trying to

Time: 4748.82

wire up correctly during development

Time: 4750.98

this is a perfect time for me to ask you

Time: 4753.199

a question that I'd love a clear answer

Time: 4755.719

on if it's possible it's not always

Time: 4758.12

possible which is

Time: 4759.739

could you define 2020 vision and a few

Time: 4763.58

of the variants so that any person could

Time: 4766.76

understand it so we think of 2020 as

Time: 4769.4

perfect vision what does that mean what

Time: 4772.34

would degraded Vision look like

Time: 4775.219

whatever those numbers are and then what

Time: 4778.1

would above normal super normal vision

Time: 4781.219

look like yeah and is it true that

Time: 4783.56

fighter pilots have Supra normal vision

Time: 4786.08

yeah that's another population like like

Time: 4788.9

like many athletes of of people who may

Time: 4792.199

have sort of better than normal vision

Time: 4794.659

2020 you know we Define almost

Time: 4797.78

everything we do based on you know kind

Time: 4801.14

of a average not sick human being adult

Time: 4805.64

whatever it is right and so 2020 Vision

Time: 4808.28

means that you can read the smallest

Time: 4812.36

letters at 20 feet away that the average

Time: 4816.56

healthy person can read

Time: 4819.56

at 20 feet away so you can read at 20

Time: 4822.38

what they can read at 20. okay now if

Time: 4825.92

you have worse than 20 20 Vision maybe

Time: 4827.96

you have 20 25 Vision 2040 Vision maybe

Time: 4830.78

you have 2200 Vision which on the eye

Time: 4833.6

chart at the office is like the Big E at

Time: 4836.36

the very top is 2200 Vision that means

Time: 4840.679

you can read at 20 feet what a normal

Time: 4844.82

person could read at 200 feet right so

Time: 4848.96

you've got pretty limited lower Vision

Time: 4851.08

we can measure down to like 2400 2800 at

Time: 4856.04

that point we're getting into like gosh

Time: 4857.84

can you count how many fingers I'm

Time: 4859.58

holding up you know that kind of thing

Time: 4861.56

and then ultimately hand motion can you

Time: 4864.26

even tell if my hand is moving in this

Time: 4866.3

side of your vision or this side of your

Time: 4867.92

vision

Time: 4869.54

and then ultimately after that light

Time: 4871.64

perception can you tell if the room

Time: 4873.5

lights are on or off right and that's

Time: 4875.239

kind of the edge of of being actually

Time: 4877.76

fully blind we call Legal blindness in

Time: 4880.34

the United States typically 2200 or

Time: 4882.739

worse and is it true that there are

Time: 4884.78

people who are legally blind that are

Time: 4886.46

out there driving as we're having this

Time: 4888.32

conversation I I have to imagine that

Time: 4890.96

that is unfortunately the case but it

Time: 4893.9

shouldn't be because those people

Time: 4895.1

obviously are really severely impaired

Time: 4897.26

and and that's obviously quite dangerous

Time: 4899.6

so so so that's 20 20. now

Time: 4903.14

it gets worse 2040 2080 20 100 can it

Time: 4906.8

get better yeah it turns out that people

Time: 4909.08

can be sort of on the other end of that

Time: 4911.42

curve and so we could have athletes and

Time: 4913.52

fighter pilots or people who have had

Time: 4915.739

LASIK surgery who are 2015

Time: 4919.6

2010. if you're 2010 that means you can

Time: 4923.54

see it 20 feet what the average person

Time: 4925.34

needs to be only 10 feet away to see

Time: 4927.739

right and so you've got better than

Time: 4930.32

normal vision and people do get to that

Time: 4932.84

through a variety of ways and so it is

Time: 4935.179

possible to have better than 20 20

Time: 4938.06

vision

Time: 4939.92

does the degree of visual Acuity because

Time: 4943.34

that's really what we're talking about

Time: 4944.36

here differ dramatically between the two

Time: 4946.94

eyes

Time: 4948.32

in most healthy people know

Time: 4951.86

um you know remember we talked about

Time: 4953.54

you're born with something like 2200

Time: 4955.52

Vision takes you a couple of years and

Time: 4957.26

it can be a little bit asymmetric 2200

Time: 4959.719

Vision yeah that reminds me um I've seen

Time: 4962.3

images of what babies can see you know

Time: 4964.46

parents love looking at their child and

Time: 4966.38

thinking their child is looking right

Time: 4967.76

back at them and indeed often the child

Time: 4969.26

is looking right back at them and your

Time: 4971.96

face to your child sorry to break this

Time: 4973.52

to you folks is incredibly blurry even

Time: 4976.76

at that close distance for probably the

Time: 4979.04

first six to eight months events before

Time: 4980.9

you come into sharp relief they're not

Time: 4982.58

seeing the fine details of your face

Time: 4984.26

yeah so smile big that's right smile

Time: 4986.9

break keep those eyebrows dark right and

Time: 4988.82

keep cooing at them because they can

Time: 4990.44

hear pretty well that's right yeah the

Time: 4992.36

Optics of newborn babies are just

Time: 4993.86

dreadfully bad yeah but they need

Time: 4995.659

visuals now other species not you know

Time: 4999.56

Hawks

Time: 5001.199

Raptors owls that hunt uh they can

Time: 5005.739

naturally have 2010 28 Vision right so

Time: 5011.14

much better vision and that's just their

Time: 5013.42

normal vision as best as has been

Time: 5015.52

measured so so there's definitely the

Time: 5018.28

potential for us to have better than 20

Time: 5021.4

20 Vision now all of this we call Visual

Time: 5023.62

Acuity and just to be clear for everyone

Time: 5025.179

that's the vision in the very center of

Time: 5028.84

your vision like when you're reading or

Time: 5030.76

looking that's the very center of your

Time: 5032.56

vision

Time: 5033.64

our vision is actually described

Time: 5035.26

variably as a hill of vision the peak is

Time: 5038.26

in the center that's let's say 2020 in

Time: 5041.199

most people right but it's it's normal

Time: 5043.78

to have that slope off and our visual

Time: 5046.12

Acuity your ability to read the eye

Time: 5047.92

chart on the edges of your vision if you

Time: 5050.32

can read the Big E that's pretty normal

Time: 5052.06

like you would be 2200 out on the edges

Time: 5055.12

of your vision and we would feel like

Time: 5057.219

yep that's pretty normal

Time: 5059.199

um so so our highest Acuity Visions in

Time: 5062.02

the center and that's a big part of why

Time: 5063.76

we spend a lot of time using those eye

Time: 5065.56

muscles to look around right we gotta we

Time: 5067.96

gotta get a little bit of a high Acuity

Time: 5069.82

view of what's around us uh fill in fill

Time: 5072.88

in the gaps of what our what our brain

Time: 5075.1

is is interpreting our peripheral world

Time: 5077.56

to look like it's almost like we have

Time: 5079.3

two visual systems we have a high Acuity

Time: 5081.4

High pixel density camera in the middle

Time: 5084.1

and then surrounding that is a pretty

Time: 5086.5

low resolution but very fast detector

Time: 5089.26

camera yes yeah yeah you mentioned Lasik

Time: 5092.44

but I want to make sure that before we

Time: 5094.48

talk about Lasik that we talk a little

Time: 5095.98

bit about contact lenses is there any

Time: 5098.52

detriment to having a piece of glass or

Time: 5101.14

a piece of plastic on the front of your

Time: 5102.58

eye all the time and the reason I ask is

Time: 5104.26

not because I think we should live

Time: 5106.199

necessarily exactly like our ancestors

Time: 5108.76

but it's a pretty bizarre adaptation

Time: 5112.659

to put a lens directly onto the front of

Time: 5115.06

the eye you have to imagine that the

Time: 5116.32

cells and tissues there are accustomed

Time: 5118.719

to getting a certain amount of oxygen

Time: 5120.159

they're accustomed to get a certain

Time: 5121.78

amount of interaction with the

Time: 5123.58

environment and and you also are now

Time: 5125.56

adding another surface the way that the

Time: 5127.78

tears are going to interact with the

Time: 5130.3

um you know with the cornea of the eye

Time: 5131.679

are probably changed and who knows maybe

Time: 5133.719

it doesn't make any negative difference

Time: 5135.76

at all but you know putting a contact

Time: 5137.86

lens on the front of the eye is you know

Time: 5140.02

about as close to putting a device on

Time: 5142

your brain as I can think of except for

Time: 5144.58

maybe the cochlear uh implant yeah yeah

Time: 5148.9

that's a great question now first of all

Time: 5151.659

um I want to distinguish uh there are a

Time: 5154.719

few really medical uses for different

Time: 5158.199

kinds of contact lenses like scleral

Time: 5160.84

contact lenses for people of certain

Time: 5162.82

diseases there are other kinds but I

Time: 5164.98

think what we really want to talk about

Time: 5166.12

right now is just kind of the

Time: 5167.38

run-of-the-mill I want to get my

Time: 5169.6

prescription taken care of but instead

Time: 5171.58

of wearing glasses I'm going to wear

Time: 5173.02

contacts

Time: 5174.719

contacts even the newest generation

Time: 5177.4

contacts yes they sort of uh change the

Time: 5182.08

tier Dynamics on the surface of your eye

Time: 5184.659

they

Time: 5186.88

um they decrease the oxygen you know

Time: 5189.58

diffusion that's just sort of out in the

Time: 5191.62

air onto the surface of our eye onto the

Time: 5194.08

cells that are on the surface of our eye

Time: 5196.38

but most of us especially as we're

Time: 5200.26

younger have enough tear film Reserve

Time: 5203.62

enough oxygen Reserve that we can easily

Time: 5207.1

tolerate these polymer gel soft contact

Time: 5210.219

lenses and and wear them happily the

Time: 5214.44

advantage of contact lenses over glasses

Time: 5218.139

purely from the perspective of

Time: 5220.6

correcting your vision is that there's

Time: 5224.08

different elements of of of of of the

Time: 5228.159

shape of your eye that need to be

Time: 5230.02

corrected if you need corrective lenses

Time: 5232.06

and so for example if you're for the

Time: 5235.239

basketball shape of your eye is a little

Time: 5237.28

too steep or a little too shallow that's

Time: 5241

what the standard glasses correct you

Time: 5245.139

may have been told that you have

Time: 5246.4

something called astigmatism that's

Time: 5248.86

where instead of having a basketball

Time: 5250.659

shaped eye you have a slightly football

Time: 5252.94

shaped die it's not round in the same

Time: 5255.28

dimensions on both axes and again

Time: 5258.34

glasses can correct that but then

Time: 5260.44

there's higher order aberrations in our

Time: 5263.38

corneas in the clear window in the front

Time: 5265.12

of our eyes or or to some degree in the

Time: 5267.82

lens inside the eye that are that are

Time: 5269.62

focusing the light that the glasses

Time: 5271.659

prescription can't correct but if you

Time: 5274.179

have a nice smooth contact lens on the

Time: 5276.58

front it can correct so a lot of people

Time: 5278.679

who wear glasses and contacts will

Time: 5280.9

report that they have a much higher

Time: 5283.06

quality of vision with their contact

Time: 5285.28

lens correction than with their glasses

Time: 5287.739

correction and again in service of

Time: 5290.58

enjoying the best Vision that you can

Time: 5293.199

enjoy in your daily life that's an

Time: 5296.139

upside to seeing if contacts could work

Time: 5298.54

Frio now there's another element though

Time: 5301.239

and that's like gosh is there a risk of

Time: 5303.34

contact lenses and especially as we age

Time: 5308.32

um we have less tear film reserves so

Time: 5311.32

contacts may become less tolerable as we

Time: 5314.08

age

Time: 5315.58

and the other thing is being really good

Time: 5317.44

about the cleaning because you know the

Time: 5319.3

contacts can trap bacteria or fungus and

Time: 5323.5

if you get a corneal infection from a

Time: 5326.02

contact lens it actually can be quite

Time: 5328

devastating to your cornea even if you

Time: 5330.1

successfully treat the infection you can

Time: 5332.08

be left with some corneal scarring

Time: 5333.88

thankfully this happens very rarely but

Time: 5337.3

when it does happen it can be quite

Time: 5338.92

difficult on you know on the person

Time: 5340.78

thereafter to sort of suffer through

Time: 5342.699

having maybe a scar from that infection

Time: 5345.04

on the surface of their cornea that they

Time: 5346.96

that leads to some blurring vision for

Time: 5349

example so we always recommend that if

Time: 5352.78

you're going to wear contacts that you'd

Time: 5354.699

be really attentive to whether you're

Time: 5356.38

tolerating them well

Time: 5357.94

and then also to be really attentive to

Time: 5360.46

the recommended use and cleaning of the

Time: 5362.92

contact lenses I actually recommend that

Time: 5365.86

even though they're a little more

Time: 5367.3

expensive to afford that people should

Time: 5369.82

almost always be just using the daily

Time: 5371.98

contact lenses that they don't have to

Time: 5374.679

clean or use for you know two weeks or

Time: 5377.32

four week period so these are disposable

Time: 5379.6

contacts highly disposable and I hate to

Time: 5381.76

think of you know I don't know filling

Time: 5383.32

our oceans or what have you with uh more

Time: 5385.36

more more polymer plastic but at least

Time: 5387.699

the contact lenses are small and it's

Time: 5389.92

much safer for your eye to use a daily

Time: 5392.92

disposable than to use a two week or a

Time: 5395.32

four week and be responsible for the

Time: 5397.239

cleaning the other thing to be really

Time: 5399.58

responsible about is sleeping in them

Time: 5402.28

overnight because overnight when your

Time: 5404.199

eyelids are closed of course now you're

Time: 5405.639

getting even less oxygen to the surface

Time: 5408.219

of your eye actually most bacteria

Time: 5410.739

especially many of the Infectious

Time: 5412.36

bacteria to our bodies and to the

Time: 5414.58

surface of our eye are actually bacteria

Time: 5417.52

that Don don't really like oxygen and so

Time: 5420.46

we've got a low risk of getting

Time: 5422.32

bacterial infections on the surface of

Time: 5424.36

our eye but if we use contacts too much

Time: 5427.239

don't clean them or sleep in them

Time: 5429.159

overnight when our eyelids are closed

Time: 5430.54

and now there's even less oxygen kind of

Time: 5432.88

helping keep the surface more more clean

Time: 5435.219

if you will that increases the risk a

Time: 5438.159

lot so being really good with the

Time: 5441.04

recommended use and cleaning of the

Time: 5442.9

contacts is critical considering daily

Time: 5445.12

use contacts you don't have to and look

Time: 5447.1

most contacts are going to be the two

Time: 5448.42

week or four-week kind where you put

Time: 5450.1

them in the cleaning solution overnight

Time: 5451.6

each time give them a good rinse and put

Time: 5453.4

them back in the next day and again most

Time: 5455.62

people 99.99 some percent of people are

Time: 5459.1

going to do just fine with that follow

Time: 5461.32

the instructions and never get into

Time: 5463.12

trouble

Time: 5464.139

as we age they're going to become less

Time: 5466.179

tolerable people are going to say I used

Time: 5467.739

to wear my contacts for 12 hours now my

Time: 5470.08

eyes feel really dry after six or eight

Time: 5472.36

or ten hours

Time: 5473.8

maybe some years after that they say

Time: 5475.54

gosh I could barely use it for four

Time: 5476.98

hours I only use them when I go out on a

Time: 5478.84

Saturday night uh and and that's okay

Time: 5481.6

you can you can you can back off as you

Time: 5483.82

need to back off but in the meantime if

Time: 5486.34

it helps you especially in the younger

Time: 5488.02

decades if it helps you really enjoy uh

Time: 5491.679

Your Best Vision great

Time: 5495.219

what about UV protection in eyeglass

Time: 5498.46

lenses and or contacts

Time: 5501.659

I've dealt with many questions about

Time: 5504.46

blue light I am not somebody who

Time: 5506.5

believes that all blue light is terrible

Time: 5507.94

I think it's important to avoid Bright

Time: 5510.34

Lights of any wavelength late at night

Time: 5512.44

if you want your melatonin production to

Time: 5514.36

be normal and you want to sleep well it

Time: 5515.98

doesn't matter if you're wearing blue

Time: 5517

blockers or not if you're just under

Time: 5518.38

blastingly Bright Lights it's going to

Time: 5520.719

suppress your melatonin and yet some

Time: 5522.699

people enjoy blue blockers for that

Time: 5524.199

reason nowadays A lot of people wear

Time: 5525.52

blue blocker

Time: 5527.02

glasses or blue blocking lenses or

Time: 5529.96

contacts throughout the entire day

Time: 5531.28

thinking that blue light is bad for our

Time: 5533.44

eyes during the day I happen to

Time: 5535

subscribe to the idea that we want as

Time: 5536.26

much bright light as we safely can

Time: 5537.76

tolerate during the day ideally from

Time: 5539.26

sunlight

Time: 5540.76

in order to set our circadian rhythm and

Time: 5543.4

yet a lot of eyeglasses and a lot of

Time: 5545.5

contact lenses out there have UV a and

Time: 5549.1

or UVB blocking features to them so what

Time: 5551.98

are your thoughts on this and I'm

Time: 5552.94

perfectly happy to be wrong and revise

Time: 5554.56

my my stance on this

Time: 5557.02

um yeah what what do you think about

Time: 5558.639

this UV a B blocking yeah it's a good

Time: 5562

it's it's a it's really important to

Time: 5563.8

distinguish that UV light on the light

Time: 5566.739

spectrum is right next to blue light red

Time: 5569.86

lights on the other end and of course

Time: 5571.54

infrared is beyond that and our eyes

Time: 5574.36

other animals can see these but our eyes

Time: 5576.699

can't see infrared that's why we call it

Time: 5579.04

Beyond red and we can't see ultraviolet

Time: 5581.679

we call it Beyond violet UV light is

Time: 5585.28

right next to Blue Light UV light is

Time: 5588.82

known to have a lot of adverse effects

Time: 5592.659

it's not really good for our skin and

Time: 5595

therefore you know we really want to

Time: 5596.32

avoid Sunburn and kind of UV data you

Time: 5598.84

know exposure and damage on our skin

Time: 5600.6

similarly it's not really good on our

Time: 5602.8

eyes and it affects both the ocular

Time: 5604.719

surface a little bit in terms of like

Time: 5606.46

kind of how dry or irritable your eyes

Time: 5608.32

might feel for some people and certainly

Time: 5610.96

over the long term UV light will

Time: 5614.199

accelerate the formation of cataract

Time: 5616.54

which is a blurring of an oxidative

Time: 5619

blurring of the lens inside the eye

Time: 5621.3

profound UV light can be damaging to the

Time: 5624.219

retina if you're getting way too much on

Time: 5626.02

the inside

Time: 5627.36

so uh so blocking UV light I believe is

Time: 5631.659

just absolutely standard in every pair

Time: 5635.32

of eyeglasses and I don't know actually

Time: 5638.62

how much to what degree the different

Time: 5640.3

kinds of contact lenses also filter at

Time: 5643.12

least UV light now blue blockers blue

Time: 5646.12

blocking glasses is totally different

Time: 5648.46

and

Time: 5650.26

as I say like I think almost all glasses

Time: 5652.54

because the Plastics almost all glasses

Time: 5654.94

are not made of glass anymore they're

Time: 5656.26

made of plastics but I think almost all

Time: 5658.96

of them now filter the UV light which

Time: 5661.239

again is like probably the safe move for

Time: 5664.179

our eyes and periocular environment

Time: 5666.639

around the eye environment

Time: 5668.52

so blue blockers you know that's been a

Time: 5672.219

huge fan I'll tell you the last three

Time: 5673.719

years through the pandemic everybody

Time: 5675.219

getting on their computer hours in front

Time: 5677.86

of Zoom meetings where we used to walk

Time: 5679.659

from building to building for a meeting

Time: 5681.4

things like that

Time: 5683.5

um I you know I I remember you know like

Time: 5686.44

this sort of big uptick in these kinds

Time: 5689.679

of questions and I'm not sure that

Time: 5692.86

there's any data that blocking blue is

Time: 5695.82

helpful in any way and as you say it may

Time: 5699.1

actually play into sort of circadian

Time: 5701.8

entrainment of our natural daily Rhythm

Time: 5704.38

so so I think blocking UV is a good idea

Time: 5707.139

and I think it's pretty standard you

Time: 5709.6

know they make glasses is by the way

Time: 5711.1

that actually react to UV light they're

Time: 5713.98

called transitions there may be a few

Time: 5715.6

different brands I don't know uh but but

Time: 5718

you know these are the sunglasses that

Time: 5720.1

are clear except then they turn dark if

Time: 5723.699

you're out in the sunlight and it's not

Time: 5725.62

just any sunlight it's actually the UV

Time: 5728.76

wavelengths that that cause the chemical

Time: 5731.38

reaction in the glasses to turn from

Time: 5733.9

from Clear see-through to to sunglass

Time: 5736.12

blocked glasses

Time: 5737.8

and um

Time: 5739.42

you may notice if you if any of you out

Time: 5741.88

there are using these kinds of glasses

Time: 5743.62

uh that they don't work in the car

Time: 5745.84

you'll wear them in the car and they

Time: 5747.94

won't go to sunglasses even though it's

Time: 5749.679

sunny out and again that's because all

Time: 5752.02

standard car glass also filters UV

Time: 5755.139

that's why if you're riding around in

Time: 5756.52

the car and it's sunny out you've got

Time: 5757.84

your hand you know up next to the window

Time: 5759.88

uh wearing a t-shirt you never get a

Time: 5762.58

sunburn through the car window anymore

Time: 5764.199

because all our car glasses also

Time: 5766.6

filtering UV light for us so so that's a

Time: 5770.62

very informative answer and before we

Time: 5772.6

started recording you and I were

Time: 5773.92

discussing this practice of morning

Time: 5775.36

sunlight viewing which again I highly

Time: 5777.46

recommend over and over and you pointed

Time: 5780.159

out that low solar angle sunlight so

Time: 5783.219

sunlight low in the sky viewed for maybe

Time: 5786.04

10 minutes a morning and again not

Time: 5787.48

forcing oneself to look at it and stare

Time: 5789.52

but blinking as needed is not going to

Time: 5792.1

cause extensive UV damage to the eyes

Time: 5794.739

it's really the when the sun is directly

Time: 5796.9

overhead that we're getting a lot of UV

Time: 5800.199

which raises this other question which

Time: 5802.6

is for people that don't wear corrective

Time: 5804.159

lenses and therefore are not blocking UV

Time: 5806.5

light to the eyes

Time: 5808.179

um what should they do are they in

Time: 5810.04

trouble should they be wearing a brimmed

Time: 5811.54

hat brimmed Hat's a great idea that I've

Time: 5814

got a rid of a lot of the direct light

Time: 5815.62

into the eye of course you still have

Time: 5817.3

reflected light off of surfaces and that

Time: 5820.179

that can include UV light of course

Time: 5823.6

um you know wearing sunglasses outside

Time: 5825.219

even if you don't have corrective lenses

Time: 5827.08

you know it's may also be more

Time: 5828.76

comfortable to wear sunglasses outside

Time: 5831.94

um so so these are all fine you know

Time: 5834.699

at the end of the day it's probably not

Time: 5836.44

making a huge difference in the health

Time: 5838.48

of your eye whether you've spent the

Time: 5840.04

last 50 years wearing sunglasses really

Time: 5842.32

dogmatically for your outdoor time or

Time: 5844.54

not you know if you were going to

Time: 5847.06

develop let's just say age-related

Time: 5849.04

cataracts inside your eyes which

Time: 5851.98

we'll all get if we all live to 120 we

Time: 5854.92

all get cataracts you know it's going to

Time: 5856.719

happen some people younger some people

Time: 5858.28

older maybe if you were really dogmatic

Time: 5860.92

about wearing your UV blocking

Time: 5862.48

sunglasses maybe you'd get your your

Time: 5864.219

cataracts at 75 years old instead of 72

Time: 5866.92

years old it may not be a huge

Time: 5868.6

difference in that regard so again not

Time: 5871.659

something to be super stressed I think

Time: 5873.34

it's I think it's more a question of

Time: 5874.6

just what are you comfortable in uh and

Time: 5877

then certainly I will say the the other

Time: 5878.86

advantage of a wide brim hat is it's

Time: 5881.26

keeping sun off of your face and these

Time: 5883.48

are the you know some of the especially

Time: 5885.34

the upturned portions of your face like

Time: 5887.38

the cheeks and the nose these are the

Time: 5888.94

some of the most common places to get

Time: 5890.86

some of the skin cancers that you can

Time: 5892.54

get over a lifetime of sunlight exposure

Time: 5895.02

so you know the wide brain app is it's

Time: 5897.94

helping you for that as well

Time: 5900.219

can't help but ask about comfort

Time: 5902.8

at varying levels of brightness I'm the

Time: 5905.5

person that when sitting in a cafe or

Time: 5907.6

something and on a bright day I can be

Time: 5909.34

directly across from somebody like you

Time: 5910.9

who seems to be perfectly fine without

Time: 5912.699

sunglasses and maybe even more shaded

Time: 5914.62

under an umbrella or something of that

Time: 5916

sort and I'm squinting like crazy

Time: 5918.639

is it normal for there to be a pretty

Time: 5921.34

wide variation in sensitivity to light

Time: 5923.8

and does this have anything to do with

Time: 5925.719

the lightness or darkness of the eyes

Time: 5927.159

you have brown eyes I have green eyes

Time: 5929.26

but is there any real correlation there

Time: 5931.3

yeah you know it's a good question I

Time: 5933.46

don't know if it's been formally studied

Time: 5934.96

but I will tell you like I have the same

Time: 5936.88

impression you do which is that if you

Time: 5939.219

have uh blue eyes or light-colored eyes

Time: 5942.52

that you're more likely to have more

Time: 5945.28

sensitivity we know that there's

Time: 5947.62

differences in the iris muscles that

Time: 5950.02

constrict and dilate in response to

Time: 5952.659

light

Time: 5953.46

for example when you go into your eye

Time: 5956.139

care provider and they're going to do a

Time: 5957.58

dilated exam and they put the eye drops

Time: 5959.8

in your eye that dilate the eyes they

Time: 5961.659

sort of change the the nerve impulses

Time: 5964.42

onto the iris muscles of the iris

Time: 5966.88

dilates and you get those big big open

Time: 5969.639

eyes

Time: 5971.38

um people with blue eyes we absolutely

Time: 5973.84

know blue or Hazel or light colored eyes

Time: 5976

uh you put that eye drop to dilate there

Time: 5978.58

rise it's going to last four six eight

Time: 5981.4

hours whereas in a brown-eyed person

Time: 5983.26

often the dilation only lasts one two

Time: 5985.659

four hours so there's clearly biological

Time: 5989.199

differences between the irises and their

Time: 5992.32

muscles and maybe the nerves that feed

Time: 5993.94

those muscles uh between light-eyed

Time: 5996.46

people and and darker eyed people and

Time: 5999.1

that may also therefore relate to this

Time: 6002.52

differential sensitivity that some

Time: 6004.56

people have you know if you're not able

Time: 6006.179

to constrict your eyes in the bright

Time: 6008.34

light as effectively you're going to

Time: 6010.86

find that bright light more frustrating

Time: 6013.44

more annoying uh you know even painful

Time: 6016.199

people will feel like their eyes are

Time: 6017.639

cramping almost as they try to get that

Time: 6020.88

those eye muscles to activate to bring

Time: 6023.4

down the pupil and block some of that

Time: 6025.98

excess light from getting in interesting

Time: 6028.38

yeah let's go back to Lasik what is

Time: 6030.78

LASIK and

Time: 6032.76

should I get Lasik eye surgery does it

Time: 6035.76

does everyone need Lasik can it help

Time: 6037.199

every can it make us you know

Time: 6038.659

suprophysiological you know can it make

Time: 6040.98

me a 2010. you know often it can I'll

Time: 6043.98

just say that you know right up front it

Time: 6045.84

is amazing people will come out of Lasik

Time: 6048.239

surgery uh better than 2020 but uh the

Time: 6052.5

cornea we talked about before that's the

Time: 6054.3

Clear Window on the front of your eye

Time: 6056.04

all the light has to get through there

Time: 6057.48

and we talked about before already like

Time: 6059.46

if your cornea is misshapen if the

Time: 6061.679

basketball shape of it is too too

Time: 6064.26

shallow or too steep then you're going

Time: 6066.6

to need glasses to see a distance and

Time: 6068.699

also at near if it's to football instead

Time: 6071.58

of basketball then it's going to be what

Time: 6073.139

we call astigmatism and uh and then you

Time: 6076.199

can't you need a correction for that

Time: 6078.84

instead of correcting with glasses that

Time: 6081.6

sort of help shape the light so it can

Time: 6084

go through your slightly off-shaped

Time: 6086.76

cornea instead of wearing contact lenses

Time: 6089.58

which also shape the light just as it's

Time: 6091.98

entering your cornea right on the

Time: 6093.54

surface of the eye you can just reshape

Time: 6096.48

the cornea

Time: 6097.92

and the way Lasik does that there's a

Time: 6100.139

few different versions of Lasik but

Time: 6102.96

basically the way the Lasik does that is

Time: 6105

it actually ablates or uh gets rid of a

Time: 6110.1

little ring or rim of that corneal

Time: 6113.58

tissue

Time: 6114.659

so that for example if you were a little

Time: 6117

shallow and you got rid of a little bit

Time: 6119.94

of that tissue around the edge with the

Time: 6122.04

laser the Lasik you know starts with the

Time: 6124.739

word laser if you got rid of that edge

Time: 6127.02

tissue then you're sort of making it a

Time: 6128.82

little more basketball shaped right or

Time: 6130.98

if you were too steep on your cornea and

Time: 6133.619

you used the laser to kind of shave off

Time: 6135.54

a little bit of the the tip of that

Time: 6137.46

basketball right then you're flattening

Time: 6139.56

it out flattening out the cornea so it's

Time: 6141.659

that kind of reshaping and the

Time: 6143.76

technology has come so far that the

Time: 6148.5

Lasik procedures can actually correct

Time: 6151.26

not just the regular aberrations that we

Time: 6154.8

talked about but also some of these

Time: 6156.659

higher order aberrations and there are

Time: 6159.119

different monikers for this kind of

Time: 6160.98

Lasik it's all I think become fairly

Time: 6162.659

standard but wave front guided where

Time: 6165.36

it's actually using light waves to

Time: 6167.82

measure with a very exact localization

Time: 6170.36

exactly how much and where to laser for

Time: 6173.28

each individual eye to make that cornea

Time: 6176.34

pass the light as ideally as possible

Time: 6178.86

now one or a few percent of patients

Time: 6181.5

will actually have a dry eye problem so

Time: 6184.44

after a Lasik because so it does

Time: 6186.659

interfere a little bit with those

Time: 6187.98

corneal nerves for example and I and I

Time: 6190.86

do think that if you're a person who

Time: 6192.659

already has dry eye hopefully if you're

Time: 6195.119

asking your eye surgeon about Lasik

Time: 6197.82

hopefully you're being counseled that if

Time: 6200.159

you have dry eye this might not be a

Time: 6202.5

good idea for you just like contacts

Time: 6204.36

might not be a good idea for you if you

Time: 6206.1

already have a lot of dry eye but for a

Time: 6208.86

lot of people especially a lot of

Time: 6210.06

younger people it's quite common I I

Time: 6211.98

think the statistics suggests maybe 15

Time: 6213.96

or 20 percent of people who would

Time: 6216.54

benefit from LASIK you know who who

Time: 6218.4

would who would otherwise be wearing

Time: 6220.08

glasses may get Lasik at some point in

Time: 6222.179

their life and

Time: 6223.8

um you know I used to joke

Time: 6226.139

you know Lasik it costs more money than

Time: 6228.54

a pair of glasses but

Time: 6230.88

it doesn't cost more money than 10 pairs

Time: 6233.46

of prescription glasses over the course

Time: 6235.139

of a decade or two you know and so I

Time: 6238.02

used to joke that gosh if uh if everyone

Time: 6240.48

had to have laser eye surgery for their

Time: 6243.42

best vision

Time: 6244.739

and someone came along and said hey I've

Time: 6247.44

got an invention you don't have to have

Time: 6249.42

laser eye surgery anymore it rests on

Time: 6252.6

the ears and the bridge of your nose I

Time: 6254.28

call them glasses could they have sold

Time: 6256.739

those for a thousand two thousand

Time: 6258.36

dollars a pair I don't know maybe but

Time: 6260.699

you know there's kind of a cultural

Time: 6262.38

element of saying you know like I don't

Time: 6264.36

want to wear glasses you know I'd love

Time: 6266.28

to be able to walk around without

Time: 6267.36

relying on glasses or contacts of course

Time: 6269.88

people are very athletic or spending a

Time: 6272.159

lot of their time doing Athletics they

Time: 6273.9

may be quite irritated to have to deal

Time: 6275.639

with glasses or contacts people who have

Time: 6278.34

very severe prescriptions I mean if you

Time: 6280.619

wake up and you can't even really you

Time: 6282.6

know you're fumbling for your glasses on

Time: 6284.52

the bedside table because you have such

Time: 6286.38

a strong strong prescription you can't

Time: 6289.26

even see what it says on the alarm clock

Time: 6291.3

next to the bed you know these are all

Time: 6294.119

groups of patients who like really

Time: 6296.1

change their daily lives by getting out

Time: 6298.86

of glasses or contacts and taking

Time: 6301.26

advantage of Lasik and in I don't know

Time: 6303.84

99 of the time it's going to be like a

Time: 6306.659

safe comfortable outcome for the patient

Time: 6308.76

do they do Lasik on kids

Time: 6312.42

um there are certain conditions uh

Time: 6315.48

unusual cordial conditions where

Time: 6317.34

procedures like Lasik get used but I

Time: 6319.739

believe uh it's ideal to not do it on

Time: 6323.52

children uh or even even young teenagers

Time: 6327

and the reason goes back to what we were

Time: 6329.159

talking about before you are much more

Time: 6331.5

likely to change the shape of your eye

Time: 6334.38

and therefore the prescription you need

Time: 6337.02

and therefore what exactly the Lasik

Time: 6339.96

would laser while you're still in those

Time: 6342.3

growing years and you really want to be

Time: 6344.88

able to say hey my eyeglasses

Time: 6347.4

prescription has not changed in the last

Time: 6349.679

two or three or five years because if

Time: 6352.5

you do Lasik and then your eye keeps

Time: 6355.02

changing shape then by the next year all

Time: 6358.139

of a sudden the lasik's not doing you're

Time: 6360.119

backing glasses again right you can do a

Time: 6362.52

touch-up Lasik do a little bit more but

Time: 6365.04

it's generally you know you're going to

Time: 6366.78

be a happier person if you've reached

Time: 6369.48

that point in your life and maybe that's

Time: 6371.46

maybe that's your late teens more

Time: 6373.199

commonly it's into the 20s where your

Time: 6375.719

eye has stopped changing its

Time: 6377.46

prescription every year you've been

Time: 6379.619

steady and stable for some years and now

Time: 6382.38

you do the Lasik and it could easily

Time: 6384.239

last you a decade

Time: 6386.4

you mentioned dry eye

Time: 6388.8

get a lot of questions about dry eye and

Time: 6391.32

a few years ago I think you and I were

Time: 6393.36

at a meeting and someone

Time: 6394.92

who is very woven in with the companies

Time: 6398.34

that

Time: 6399.54

build and test drugs for different

Time: 6402.659

aspects of vision health said you know

Time: 6405.48

what the field really needs is a

Time: 6408.119

treatment that works for dry eye and I

Time: 6410.28

thought dry eye like of all things like

Time: 6412.5

why dry and then the more I learned

Time: 6413.88

about it I realized that there are

Time: 6415.98

millions and millions of people that

Time: 6417.48

really suffer from dry eye and for whom

Time: 6420.239

standard drops are just not working so

Time: 6423.239

what underlies dry eye is it some

Time: 6425.219

deficiency in the lacquer hormone glands

Time: 6426.96

that produce tears for the eye and and I

Time: 6429.36

think of Tears as just kind of salty

Time: 6430.739

water

Time: 6431.84

and I wonder if they are more than that

Time: 6434.82

is there an oil in there and if we know

Time: 6437.52

what's in tears why can't somebody just

Time: 6439.56

manufacture something that works as well

Time: 6441.36

as tears yeah you know it turns out you

Time: 6444.9

know we we've got a lot of other eye

Time: 6446.88

diseases

Time: 6448.28

but by far the most common eye disease

Time: 6452.34

and and I've been told by far the most

Time: 6455.04

common eye treatment you know purchased

Time: 6458.58

by anyone now granted it's almost always

Time: 6460.26

over the counter things like artificial

Time: 6462.239

tears is for dry eye

Time: 6464.4

and uh in part that's because as we age

Time: 6467.52

our

Time: 6469.02

tier quantity goes down and our tier

Time: 6472.8

quality goes down and so what do those

Time: 6474.659

do mean

Time: 6476.28

we have two different major elements to

Time: 6479.46

tiers and as you alluded to one is the

Time: 6482.52

salt water porn of part of the tears and

Time: 6485.04

those are made primarily by the lacrimal

Time: 6487.26

gland and there's a steady drip of those

Time: 6489.239

tears onto the ocular surface as well as

Time: 6491.58

reflexive tearing right if you get an

Time: 6493.38

eyelash in your eye or or you cry your

Time: 6496.5

lacrimal ground will actually squeeze

Time: 6498.179

out extra salt water tears uh onto the

Time: 6501.3

surface of the eye and so so that's

Time: 6503.34

that's where most of the sort of wet

Time: 6505.56

part is coming from but there's also

Time: 6508.02

essential oils critical oils these come

Time: 6511.619

from other types of glands including

Time: 6513.659

glands in our eyelids called meibomian

Time: 6515.58

glands and the oils form a surface over

Time: 6520.159

the salt water part of the tear film

Time: 6524.159

and and also intermix into the tears and

Time: 6528.36

as we age we go down in the quantity of

Time: 6532.56

both salt water part of our tears and

Time: 6535.08

oil part of our tears but also the

Time: 6537.9

quality and in particular the oil parts

Time: 6541.159

uh can often be seen to be going down

Time: 6544.08

more quickly

Time: 6545.719

the the eye drop industry has pretty

Time: 6550.679

much solved for replacing the salt water

Time: 6553.679

part of your tears right you can get

Time: 6556.08

either bottles of preserve preservative

Time: 6559.679

containing you know you could use that

Time: 6561.659

bottle all month or for a month or two

Time: 6563.58

or you can buy these strips of

Time: 6565.739

preservative free artificial tears which

Time: 6568.679

are really basically like the salt water

Time: 6570.84

components and you can use those

Time: 6572.4

preservative free ones we have patients

Time: 6574.26

using them every hour if they need to

Time: 6577.02

right you're not going to hurt anything

Time: 6578.46

with preservative free artificial tears

Time: 6580.619

you just drop them in just drop them in

Time: 6582.48

yeah either I as as often as you want or

Time: 6584.88

need when you feel it it's exacerbated

Time: 6588.36

in the world we live in uh

Time: 6591.6

especially these days now with more time

Time: 6594

on computer it turns out that when you

Time: 6596.699

read including when we maybe used to

Time: 6599.34

read more books than we do now but also

Time: 6601.38

read on the computer or stare at the

Time: 6603.179

computer screen or work on the computer

Time: 6604.98

or actually just even watch the TV

Time: 6607.86

I've done very careful studies you blink

Time: 6610.199

less when you're doing any of those

Time: 6612.42

activities

Time: 6614.04

and when you blink glass you're

Time: 6615.8

redistributing the tears less

Time: 6618.36

effectively and you're squeezing out

Time: 6621.54

less of the tears including less of the

Time: 6623.88

oils as effectively as you could be when

Time: 6626.699

you're blinking and so

Time: 6629.46

um so between aging tier quality tier

Time: 6632.699

quantity

Time: 6633.84

a lot of our activities

Time: 6635.94

we're kind of in this losing proposition

Time: 6638.219

now now I mentioned that uh we're pretty

Time: 6640.679

good at replacing the wet salty part of

Time: 6642.6

our tears but actually as an industry we

Time: 6645.3

haven't really figured out a

Time: 6647.58

how to really effectively replace the

Time: 6650.219

oily part and the oils do a few things

Time: 6652.739

including when you have a layer of oil

Time: 6655.139

on top of a layer of water

Time: 6657.42

the water is less likely to evaporate

Time: 6660.239

and so the oils help hold the tears on

Time: 6663.239

the surface of your eye and so if we're

Time: 6664.739

not making as many or as good oils as

Time: 6667.98

part of our tear film that's uh that's

Time: 6670.44

also like kind of working against the

Time: 6672.659

salt water part of our tears

Time: 6675

um so yeah as an industry as a community

Time: 6678

uh that we haven't really figured out

Time: 6680.94

how to get the oil part solved for

Time: 6683.04

either by effectively replacing the oils

Time: 6686.88

or

Time: 6688.44

treating our eyelids in a way kind of

Time: 6690.6

rejuvenating those oil glands getting

Time: 6693

them to kind of go back to their

Time: 6694.8

youthful State again you know so that

Time: 6696.84

the eyes including the eyelids and the

Time: 6699.119

oil glands unfortunately they're aging

Time: 6700.679

just like the rest of our body so so

Time: 6703.02

this is this this is one of the major

Time: 6705.239

features uh is uh is dry eye and and uh

Time: 6709.5

and it's tough on patients because you

Time: 6711.659

feel it it's really tough because you

Time: 6713.82

feel it yeah I have yet another

Time: 6716.119

experience to report where when I had

Time: 6719.04

the blepharitis which fortunately was

Time: 6721.56

transient I also experienced it every

Time: 6723.3

time I would blink I could feel the

Time: 6724.92

blink and boy I'll tell you I we all

Time: 6729.239

most of us take for granted uh what a

Time: 6732.6

pleasure it is to not observe the

Time: 6734.82

blinking of our eyes because for those I

Time: 6737.4

think in last about two weeks every time

Time: 6739.32

I blink I'd feel an almost sandpaper

Time: 6741.3

like experience it wasn't particularly

Time: 6743.219

painful but it was very uncomfortable

Time: 6745.199

because it suddenly conscious of every

Time: 6747.119

blink and it's very very distracting now

Time: 6749.88

that resolved when the blepharitis

Time: 6751.619

resolved but I can't even imagine what

Time: 6753.78

it would be like to deal with that all

Time: 6755.159

day long every day yeah really Dreadful

Time: 6757.44

yes it really is and it and so you're

Time: 6760.679

absolutely right it's a very it's one of

Time: 6762.6

our really big unmet needs and and

Time: 6764.639

although for most people with dry eye it

Time: 6767.639

can be managed with just the regular

Time: 6769.52

over-the-counter artificial teardrops

Time: 6771.78

you can buy at the grocery store or over

Time: 6773.639

the counter at the pharmacy for a subset

Time: 6776.219

of people who have really much more

Time: 6777.84

severe symptoms with the dry eye it's

Time: 6780.36

it's really it's hard it's a really hard

Time: 6782.219

thing to have to live with all the time

Time: 6783.659

and and we Counsel on the use of Tears

Time: 6786.119

we Council on the use of eyelid cleaning

Time: 6789.06

like we talked about before where you

Time: 6790.739

take either these eyelid scrubs or a

Time: 6792.54

little dilute baby shampoo to keep those

Time: 6794.639

eyelashes really clean that keeps those

Time: 6797.159

oil glands functioning at their top

Time: 6799.38

capacity for you uh so that you're

Time: 6801.78

maximizing you know high quality cheer

Time: 6803.76

production reducing inflammation is also

Time: 6806.82

important whether that's inflammation

Time: 6808.32

from allergy and of course a lot of

Time: 6809.94

people's dry eye gets much worse in the

Time: 6812.88

spring with seasonal allergies when

Time: 6814.86

pollen is around if you have dust

Time: 6816.9

allergies in your home uh that worsens

Time: 6820.139

your symptomatic dry eye

Time: 6823.1

or other forms of inflammation there's a

Time: 6825.78

there's an element of dry eye that we

Time: 6827.52

actually think is

Time: 6829.159

inflammation kind of working against our

Time: 6831.659

tear glands and and in fact some of the

Time: 6834.06

prescription drops now to help combat

Time: 6836.76

more severe dry eye uh are

Time: 6839.6

anti-inflammatory or even low-dose

Time: 6841.679

steroid types of eye drops

Time: 6844.5

um so I think these are all uh sort of

Time: 6846.659

Next Generation treatments I think at

Time: 6848.94

the at the really Leading Edge of Next

Time: 6851.1

Generation treatment is trying to better

Time: 6852.719

understand the nerves on the cornea and

Time: 6856.139

ocular surface and if there are ways

Time: 6858.179

that we could better treat them and help

Time: 6859.98

help regenerate and rejuvenate kind of

Time: 6862.679

how the nerves and the and the tissue

Time: 6865.619

cells are interacting underneath that

Time: 6867.84

tear film and that's where for some

Time: 6870.06

patients we can actually use either for

Time: 6872.76

example blood serum your blood serum is

Time: 6874.92

actually very rich in growth factors

Time: 6878.4

and many of those growth factors it

Time: 6880.92

turns out empirically are really helpful

Time: 6883.32

for people with dry eye so if you're one

Time: 6886.5

of those people who's been really

Time: 6887.94

struggling with with dry eye you might

Time: 6890.1

ask your eye care provider hey I heard

Time: 6892.26

about serum tears is that something that

Time: 6894.42

could help me serum tears because this

Time: 6897.36

PRP is this platelet-rich plasma related

Time: 6899.88

but but not the plate platelet-rich

Time: 6902.34

portion at least not yet they can draw

Time: 6905.04

your blood spin out all the cells you're

Time: 6907.5

left with the kind of liquid part of

Time: 6909.179

your blood that's the serum and then

Time: 6911.159

they can dilute that with some salt

Time: 6913.08

water maybe with some preservatives in

Time: 6915.119

some cases yeah you could keep it in

Time: 6917.1

your freezer thaw a bottle when you're

Time: 6919.08

ready to use it you know each few weeks

Time: 6921.3

and and then use it just like an

Time: 6923.46

eyedropper bottle and those serum tears

Time: 6926.119

uh actually can be very helpful for

Time: 6928.86

people with with much more advanced or

Time: 6930.9

severe hard to control dry eye symptoms

Time: 6933.84

uh companies are really trying to figure

Time: 6936.36

out hey what are the most important

Time: 6938.04

parts of the the serum can we just

Time: 6940.8

identify and package just the growth

Time: 6943.44

factor and uh and turn that into a

Time: 6946.32

product for dry eye patients and so

Time: 6948.179

there's a lot of research on the ocular

Time: 6950.46

surface and dry eye uh going into

Time: 6954.179

um going into that space right now I'll

Time: 6956.46

tell you the one other recommendation

Time: 6957.96

that I always give patients

Time: 6960.9

there's a fair amount of evidence that

Time: 6963

if you're getting too much of some of

Time: 6965.28

these preservative chemicals which of

Time: 6968.46

course if you're going to use an eye

Time: 6969.6

drop bottle for a month it should have a

Time: 6971.82

preservative in it right so that you

Time: 6973.44

know open the bottle and then it grows

Time: 6975.06

bacteria a couple weeks later and now

Time: 6976.98

you're you're you know you're using

Time: 6978.719

contaminated eye drops so for bottles

Time: 6982.02

it's typical to have preservatives but I

Time: 6984.3

really recommend for patients if they're

Time: 6986.219

using anything more than a couple drops

Time: 6988.199

here and there for their dry eye control

Time: 6990.719

to actually go for one of the

Time: 6992.76

preservative free artificial tears they

Time: 6995.699

come in lots of Brands I'm sure the

Time: 6997.44

house brands at any of the pharmacies

Time: 6999.42

use them too I make them too and these

Time: 7001.94

are the ones that come in like strips

Time: 7003.619

plastic strips and you break one off you

Time: 7006.619

break off the little cap you can use as

Time: 7008.719

much as you want all day you have to

Time: 7010.76

throw that one out if you have anything

Time: 7012.32

left over you have to throw it out at

Time: 7014.179

the end of the night and the next day

Time: 7015.739

break off a new one because there's no

Time: 7017.36

preservatives and once you open it you

Time: 7020

don't want bacteria to grow in that salt

Time: 7022.1

water right but it's really good because

Time: 7025.4

the preservatives can be very irritating

Time: 7027.739

or even inflammatory to the ocular

Time: 7029.78

surface to the surface of our eyes so we

Time: 7032.3

really do want to if we're using more

Time: 7034.52

than a drop or two

Time: 7036.08

upgrade that cost a little bit more

Time: 7037.82

money if they're still over the counter

Time: 7039.38

upgrade yourself to the preservative

Time: 7041.3

free artificial tears those are great

Time: 7043.639

recommendations I'm also really

Time: 7046.34

interested in this serum

Time: 7048.56

thing uh because you know we're this

Time: 7051.32

discussion taking place 10 years ago and

Time: 7054.679

I raise PRP platelet-rich plasma there

Time: 7058.4

would probably be a lot of eye rolls no

Time: 7059.96

pun intended because I think myself and

Time: 7062.119

a lot of other people in the let's call

Time: 7063.86

the sort of standard scientific and

Time: 7065.54

medical community looked at

Time: 7066.86

platelet-rich plasma right alongside

Time: 7068.599

stem cell therapies because they were

Time: 7070.159

cheek to jowl back then as you recall

Time: 7071.84

before the FDA regulations about stem

Time: 7073.639

cell claims which we will get to

Time: 7076.099

um of course

Time: 7077.719

PRP was suggested as a source of stem

Time: 7080.119

cells it turns out there are very few if

Time: 7082.099

any true stem cells in PRP and yet now

Time: 7084.679

as I understand it PRP is an FDA

Time: 7087.56

approved protocol for injection into the

Time: 7091.88

uterus injection into pretty much every

Time: 7095.42

tissue and organ system of the body in

Time: 7097.699

order to quote unquote rejuvenate it and

Time: 7100.04

here I'm not promoting PRP and yet it is

Time: 7102.44

a very common practice now in more

Time: 7104.599

standard medical clinics but it started

Time: 7106.219

off kind of Niche even gray Market kind

Time: 7108.44

of underground it's diverged from stem

Time: 7110.54

cell therapies and we're going to talk

Time: 7112.699

about major modes of vision loss in a

Time: 7114.86

moment

Time: 7115.58

and this horrible situation that

Time: 7118.04

happened down in Florida of a clinic

Time: 7119.78

injecting stem cells into patients eyes

Time: 7121.699

to recover vision and it actually

Time: 7123.86

blinded them so we'll talk about stem

Time: 7126.02

cell therapies but for the record is PRP

Time: 7129.02

something that's now standard in major

Time: 7131.119

optimal ophthalmic clinics excuse me

Time: 7134.8

including your department at Stanford

Time: 7137.36

are you drawing out blood spinning it

Time: 7139.699

down taking plasma taking serum and

Time: 7142.34

re-injecting it or reapplying it to

Time: 7144.199

patients eyes not not yet in

Time: 7146.659

Ophthalmology uh in eye clinics I I

Time: 7149.3

would say we're sort of like right now

Time: 7150.92

on the edge of uh groups are starting to

Time: 7153.139

study that is it safe is it valuable is

Time: 7156.92

it any better for certain conditions

Time: 7158.659

like on the ocular surface than serum

Time: 7160.82

Tears For example this sort of diluting

Time: 7163.46

a patient's own own blood serum uh so so

Time: 7166.88

it's being studied it's a very active

Time: 7168.98

area now it turns out that this PRP

Time: 7171.639

plasma has uh you know again like a high

Time: 7175.04

concentration nation of growth factors

Time: 7177.139

that's probably what's responsible for a

Time: 7179.84

lot of the kind of quote tissue

Time: 7181.58

Rejuvenation effects uh be that be they

Time: 7184.76

as they may but but it's being studied

Time: 7187.639

but it's definitely not a standard of

Time: 7189.739

care yet uh at least in in Ophthalmology

Time: 7192.739

space and and you know I think whenever

Time: 7195.44

there's something really new it really

Time: 7197.42

deserves to be properly studied we

Time: 7199.4

talked before about you know at first

Time: 7201.739

you're going to do trials where you just

Time: 7203.42

test it carefully in a few people maybe

Time: 7205.699

a few of the most severely effective

Time: 7207.5

affected patients be really thoughtful

Time: 7210.44

about uh you know the ethics of trying

Time: 7212.719

out for safety then as you develop a

Time: 7215.36

little understanding of the safety you

Time: 7217.4

really want to eventually get to

Time: 7219.26

properly controlled randomized what

Time: 7221.9

people in the community often call

Time: 7223.159

double blind trials but we in

Time: 7224.9

Ophthalmology like to call Double masked

Time: 7226.699

trials blind is a bad word

Time: 7229.48

trials yeah yeah so you really want

Time: 7232.159

properly controlled trials testing is it

Time: 7234.8

really working thing is it really

Time: 7237.199

deserve the claims that people are

Time: 7239.719

making and that has not yet really come

Time: 7242.42

to fruition at that level for

Time: 7244.46

Ophthalmology or Eye Care yet so we've

Time: 7246.92

been talking a lot about normal visual

Time: 7248.84

development eye checks and some of the

Time: 7251.9

more typical challenges that people have

Time: 7254.239

with their vision

Time: 7255.739

but we haven't yet touched on some of

Time: 7257.659

the really debilitating stuff

Time: 7260

things like glaucoma things like

Time: 7263.36

retinitis Pigmentosa macular

Time: 7265.639

degeneration the things that if we could

Time: 7268.699

we would all avoid and yet are out there

Time: 7271.46

in the world at pretty high rates you

Time: 7274.159

know I'm sure you'll share with us what

Time: 7275.659

those rates are

Time: 7277.099

and as bad as these things are there are

Time: 7280.219

ways to detect and offset their

Time: 7283.219

progression so that people don't

Time: 7284.659

necessarily lose their Vision so if you

Time: 7287.3

could could you share with us what are

Time: 7289.219

the major forms of vision loss in

Time: 7291.86

childhood and in adulthood and what can

Time: 7294.98

each and all of us do in order to find

Time: 7297.56

out if we have one of these conditions

Time: 7299.119

and therefore treat it effectively yeah

Time: 7301.82

that's great you know

Time: 7303.8

let's start by just

Time: 7306.139

reminding ourselves what are the major

Time: 7307.94

causes of vision loss and these are

Time: 7310.88

going to differ where you are in the

Time: 7312.5

world

Time: 7313.46

but the major the number one cause of

Time: 7315.679

low vision is actually refractive error

Time: 7318.679

people who need glasses and especially

Time: 7322.04

in other countries affordability access

Time: 7325.9

can't even get glasses okay so that's

Time: 7328.88

just refractive error but that's

Time: 7330.8

fundamentally correctable

Time: 7333.26

the next most common cause of vision

Time: 7335.84

loss is cataract cataract is the

Time: 7339.679

blurring the Aging of the lens inside

Time: 7342.619

the eye behind the cornea we talked

Time: 7344.599

about how that is responsible for

Time: 7346.639

focusing light under the back of the eye

Time: 7348.26

it also has to be clear enough that the

Time: 7349.88

light gets through the lens

Time: 7351.739

and a cataract is a normal aging process

Time: 7354.92

you know as I said if we all live to 100

Time: 7356.9

or 110 years old we'll all get cataracts

Time: 7359.54

we'll all need cataract surgery we

Time: 7361.639

actually is you know in in the eye

Time: 7363.139

clinic we see cataracts years or even

Time: 7366.679

decades before they're affecting your

Time: 7368.9

vision in a meaningful way so that the

Time: 7371.42

cataracts are forming and that's okay

Time: 7373.159

but at some point they get bad enough

Time: 7375.46

that it's time to take them out we've

Time: 7378.26

actually solved for cataract surgery

Time: 7380.239

pretty efficiently we could do a four to

Time: 7384.32

eight minute surgery maybe if we're

Time: 7386.42

taking our time it's 10 or 12 minutes of

Time: 7389.119

surgical time take out a cataract it

Time: 7392.119

works beautifully 99 point something

Time: 7395.06

percent of the time we put a plastic a

Time: 7397.94

clear plastic lens inside the eye

Time: 7400.159

exactly where your lens used to be and

Time: 7403.099

there's even lenses that can Flex or

Time: 7406.099

focus light from far and near so

Time: 7408.44

cataracts is fundamentally a there's

Time: 7410.719

still room for improvement but there's

Time: 7411.739

it's fundamentally a solved problem the

Time: 7415.639

problem is is that worldwide there

Time: 7418.34

aren't enough cataract surgeons there's

Time: 7420.32

not access to care the Machinery or the

Time: 7423.739

lenses

Time: 7424.84

cost too much money in developing

Time: 7428.42

countries to get out to the number of

Time: 7430.58

people who would need them so it's

Time: 7432.92

actually just again an access to care

Time: 7434.599

cataract is a reversible treatable

Time: 7437.179

easily treatable problem

Time: 7439.82

but it's number two on the list of

Time: 7442.099

causes of vision loss in the world

Time: 7444.32

because we don't have enough access to

Time: 7446

care we need a lot more sort of

Time: 7447.52

programming around Global Ophthalmology

Time: 7449.78

Global Eye Care to solve for cataract

Time: 7452.02

just to bring that solution to countries

Time: 7455.36

around the world

Time: 7457.46

then after that you start hitting the

Time: 7460.159

eye diseases that lead to what are

Time: 7463.04

currently irreversible

Time: 7465.94

non-reversible causes of vision loss the

Time: 7469.639

number one cause of irreversible vision

Time: 7472.699

loss in the world is glaucoma

Time: 7475.76

so what is glaucoma glaucoma is actually

Time: 7477.56

probably a little cluster or

Time: 7479.239

constellation of diseases that we lump

Time: 7481.28

together it's a degenerative disease

Time: 7485.139

like a neurodegeneration we talk about

Time: 7487.52

neurodegenerations in the brain like

Time: 7489.32

Alzheimer's and Parkinson's glaucoma is

Time: 7491.659

a neurodegenerative disease it happens

Time: 7494.54

instead of affecting one or different

Time: 7496.28

area in your brain it happens to affect

Time: 7498.34

the optic nerve that connects the eye to

Time: 7501.44

the brain and we need our optic nerves

Time: 7503

to carry all the visual information from

Time: 7505.82

the eye to the brain and so if your

Time: 7507.32

optic nerve is degenerating in glaucoma

Time: 7510.92

and I should add there are other optic

Time: 7512.84

neuropathies so-called diseases of optic

Time: 7516.08

nerve degeneration for example you can

Time: 7517.699

get a stroke of the optic nerve you can

Time: 7520.219

have an inflammatory disease like

Time: 7522.5

multiple sclerosis called optic neuritis

Time: 7525.26

that affects the optic nerve so you can

Time: 7527.84

get other optic nerve diseases but

Time: 7530.54

glaucoma is by far the most common optic

Time: 7532.639

neuropathy and the problem is is just

Time: 7534.98

like you know just like spinal cord

Time: 7536.9

injury which is also part of the central

Time: 7539.179

nervous system right the brain the

Time: 7541.04

spinal cord the rat and the optic nerve

Time: 7542.78

that's the central nervous system and

Time: 7544.639

there's no regeneration and that's why

Time: 7546.679

spinal cord injury leads to permanent

Time: 7548.739

paralysis well optic nerve injury or

Time: 7551.54

optic nerve degeneration unfortunately

Time: 7553.76

leads to permanent vision loss so in the

Time: 7556.76

case of glaucoma how do we get ahead of

Time: 7558.86

that

Time: 7559.699

glaucoma has two major risk factors one

Time: 7563.659

is increasing age there are actually

Time: 7566

infantile and pediatric glaucomas

Time: 7568.88

unfortunately and those can be much more

Time: 7571.4

aggressive much more damaging when they

Time: 7573.619

present so early in kids uh in babies

Time: 7576.619

and in children

Time: 7578.659

most of the kind of run-of-the-mill

Time: 7580.46

glaucoma usually results presents in

Time: 7582.619

adulthood and even in in the Aging

Time: 7584.719

adults so much more common after 50 or

Time: 7586.76

60 or 70 years old increasing the other

Time: 7590.06

main risk factor for glaucoma is

Time: 7592.04

increasing eye pressure the eye actually

Time: 7594.92

you know it stays inflated it's a

Time: 7596.96

balloon it has to stay inflated we need

Time: 7598.94

some amount of eye pressure to keep our

Time: 7600.86

eye as a as an inflated balloon but if

Time: 7603.5

the eye pressure goes too high and we

Time: 7606.679

talked about this before you won't even

Time: 7608.179

feel it if it slowly gets too high if

Time: 7611.239

the eye pressure goes too high that

Time: 7613.82

causes glaucoma and

Time: 7616.88

um and that's one of the things that we

Time: 7618.38

talked about you really include in a

Time: 7620.84

comprehensive eye exam when you're just

Time: 7623

getting a screening checkup at your eye

Time: 7625.34

care provider at your optometrist or

Time: 7627.26

ophthalmologist office they're going to

Time: 7628.88

check your pressure and just as a

Time: 7630.56

screening tool check to make sure it's

Time: 7631.94

not too high

Time: 7634.28

we can treat glaucoma today

Time: 7637.94

by trying to reduce the impact of that

Time: 7640.76

high pressure by lowering the eye

Time: 7642.5

pressure so we have treatments for

Time: 7644.659

glaucoma that Target the eye pressure we

Time: 7647.119

have medications like eye drops we have

Time: 7649.76

lasers that can be used inside the eye

Time: 7652.219

that can also lower the eye pressure and

Time: 7655.46

ultimately if we need them we also have

Time: 7656.84

surgeries that can also provide an

Time: 7659.9

outflow that lets the fluid out of the

Time: 7661.76

eye in a controlled way so that the eye

Time: 7664.4

pressure can be brought back down into

Time: 7666.139

normal ranges

Time: 7668.48

again the reason that glaucoma

Time: 7671.9

ends up being the number one cause of

Time: 7674.719

irreversible blindness in the world is

Time: 7677.3

number one

Time: 7678.86

we can't get those therapies everywhere

Time: 7681.5

in the world the affordability of eye

Time: 7683.54

drops the access to lasers or surgical

Time: 7686.239

procedures Around The World Isn't equal

Time: 7688.34

to what it is here and even within our

Time: 7691.28

country you know people may not be

Time: 7693.5

accessing Health Care effectively to get

Time: 7696.08

screened for glaucoma or to get treated

Time: 7698

for glaucoma the other big problem with

Time: 7700.34

glaucoma is that it affects our

Time: 7702.56

peripheral vision first and only very

Time: 7706.34

late in the disease does it pinch in and

Time: 7709.52

finally pinch off the center of our

Time: 7711.199

vision in typical glaucomas

Time: 7714.56

and that's a real problem because

Time: 7716.9

we don't notice if our peripheral vision

Time: 7719.659

is down you know our peripheral vision

Time: 7721.58

isn't that good to begin with and if

Time: 7724.46

you're driving and you can see a

Time: 7725.96

pedestrian step off the sidewalk you

Time: 7728.119

think your peripheral vision is fine but

Time: 7730.88

actually your peripheral vision could

Time: 7732.44

already start being damaged by glaucoma

Time: 7735.199

and you won't notice it in regular daily

Time: 7737.84

life and that's where the importance of

Time: 7739.94

screening and early detection really

Time: 7742.46

comes in for glaucoma

Time: 7745.28

what we don't have for glaucoma we can

Time: 7747.619

come back to like kind of what's The

Time: 7749.06

Cutting Edge of the future in these eye

Time: 7751.34

diseases what we don't have are

Time: 7752.84

treatments that really Target the optic

Time: 7755.659

nerve degenerative process and we can

Time: 7758.84

come back and talk about that

Time: 7760.699

so that's glaucoma and optic

Time: 7762.32

neuropathies then the next two major

Time: 7765.86

causes of currently largely irreversible

Time: 7770.119

vision loss our age-related macular

Time: 7773.42

degeneration

Time: 7775.699

and then diabetic retinopathy now

Time: 7779.659

age-related macular generation is just

Time: 7782.3

like it sounds major risk factors age

Time: 7785.179

it's very common and actually in the

Time: 7787.76

developed world you know countries that

Time: 7790.159

are more developed also countries that

Time: 7791.599

have a larger Caucasian white population

Time: 7794.119

it's more common in certain populations

Time: 7796.46

than in others

Time: 7798.38

um it actually is you know definitely a

Time: 7801.08

leading cause of vision loss in the

Time: 7803.84

elderly population for example in the

Time: 7805.699

United States

Time: 7807.679

um and uh there's two forms of macular

Time: 7811.88

degeneration but they both end up

Time: 7814.58

targeting the same part the same part of

Time: 7817.58

the retina and the part of the retina is

Time: 7819.8

really like the rods and the cones that

Time: 7821.9

we talked about before the rods do your

Time: 7823.76

low light vision at night time primarily

Time: 7827.119

your cones do color vision and bright

Time: 7829.159

light you know sort of normal lighting

Time: 7831.38

that we experience you know through most

Time: 7833.3

of our awake day

Time: 7835.58

and in that back of the retina you can

Time: 7838.28

have what's called dry macular

Time: 7840.56

degeneration which is a slow thankfully

Time: 7844.099

slow but slow Insidious disease that

Time: 7847.76

causes the degeneration of the rods and

Time: 7850.58

cones and also the support cells that

Time: 7853.46

help feed the rods and cones and take

Time: 7855.199

care of the rods and cons they're called

Time: 7856.94

rpe cells retinal pigment epithelium

Time: 7859.82

it's not really critical of course the

Time: 7862.46

names of every different cell type but

Time: 7864.139

these are like the the the light

Time: 7866.3

collecting cells in our eyes in the

Time: 7868.52

retina and they degenerate in macular

Time: 7870.38

degeneration and in the dry form there's

Time: 7873.02

this slow degeneration but some percent

Time: 7876.139

of people with the dry form of macular

Time: 7878.179

generation will actually convert to

Time: 7879.92

What's called the wet form it's called

Time: 7882.56

wet because new blood vessels actually

Time: 7884.96

grow inappropriately under and even into

Time: 7888.619

the retina and new blood vessels unlike

Time: 7891.5

our mature blood vessels tend to be

Time: 7893.42

leaky and so now the flu fluid leaks out

Time: 7896.78

of those blood vessels gets into the

Time: 7898.52

retina interferes with vision and that

Time: 7900.26

can lead to a much more acute loss of

Time: 7903.02

vision now we have some treatments for

Time: 7907.04

wet macular degeneration we have

Time: 7909.5

injections that can go into the eye that

Time: 7911.659

actually fight against the molecules

Time: 7914.48

that are causing those new blood vessels

Time: 7916.58

to grow and these are antibodies that

Time: 7919.04

can be injected into the eye and they

Time: 7920.599

can be very effective controlling

Time: 7922.82

patients wet macular degeneration

Time: 7926

it's been a much bigger uphill battle

Time: 7928.58

even over the last decade as advances

Time: 7931.34

are being made to to really try to knock

Time: 7933.8

back or or slow down even the dry form

Time: 7937.82

of macular degeneration there was just

Time: 7940.46

some exciting news even just in the last

Time: 7942.619

few months the first uh successful

Time: 7946.219

Trials of a treatment for the dry form

Time: 7950.06

uh have just shown success and properly

Time: 7952.76

randomized controlled human clinical

Time: 7955.099

trials phase three clinical trials so

Time: 7957.92

it's an exciting time

Time: 7960.26

those new treatments are not going to be

Time: 7962.119

a Panacea they slow the progression like

Time: 7965.659

the an anatomic progression of the

Time: 7968.239

disease

Time: 7969.38

uh maybe by 20 or 25 so so patients are

Time: 7973.28

still going to get worse even with those

Time: 7975.079

treatments so there's still a lot more

Time: 7976.94

to be done to really knock back macular

Time: 7980.06

degeneration I want to mention you

Time: 7982.28

mentioned retinitis Pigmentosa that's

Time: 7984.26

like an inherited form of a type of

Time: 7988.099

macular degeneration it's also affecting

Time: 7990.38

the rods and cones and also the support

Time: 7992.9

cells the rpe cells in the back of the

Time: 7995

eye retinized Pigmentosa is an inherited

Time: 7997.639

form

Time: 7999.32

there are actually many different genes

Time: 8002.32

you could have that could leave to

Time: 8003.579

retinized pigments Pigmentosa in

Time: 8006.099

aggregate if you add up all the people

Time: 8008.619

with all those different genes uh and it

Time: 8011.8

can be very devastating because it can

Time: 8014.139

really affect the vision knock out your

Time: 8015.82

vision very early in life including in

Time: 8017.92

children and even versions of that and

Time: 8020.139

babies but you add that all up it's

Time: 8022.42

still much less common in aggregate than

Time: 8024.76

macular degeneration

Time: 8026.619

but in a way it's you know quite a bit

Time: 8028.78

more severe because it does affect

Time: 8030.28

people much earlier in life so so I sort

Time: 8033.04

of Clump those together macular

Time: 8034.78

degeneration retinitis Pigmentosa

Time: 8036.579

degeneration of the rods and cones and

Time: 8039.579

the support cells the rpe support cells

Time: 8042.34

and then you you can't have this part of

Time: 8045.219

the discussion about what are the

Time: 8046.48

devastating eye diseases without

Time: 8047.92

bringing up diabetic retinopathy

Time: 8049.78

especially because diabetes

Time: 8053.139

unfortunately really continues to grow

Time: 8055.599

in especially let's say in the United

Time: 8058.659

States certainly in the developed world

Time: 8060.76

you know as we

Time: 8063.4

um especially type 2 diabetes with

Time: 8065.619

eating habits exercise habits

Time: 8068.02

contributing to a proliferation of some

Time: 8070.84

of the risk factors for type 2 diabetes

Time: 8073.06

metabolic syndrome obesity

Time: 8076.44

we're unfortunately seeing a

Time: 8078.52

proliferation a growth in the number of

Time: 8080.5

people with diabetes and with the growth

Time: 8083.32

in diabetes unfortunately comes the

Time: 8085.06

growth of the complications of diabetes

Time: 8088.119

and one of the major complications of

Time: 8091

diabetes is damage to the retina inside

Time: 8093.699

the eye and we call that diabetic

Time: 8095.38

retinopathy and there again some of the

Time: 8098.44

same

Time: 8099.52

damage that occurs

Time: 8101.5

especially when in diabetes again some

Time: 8104.139

new blood vessels are growing or blood

Time: 8106.119

vessels are leaky some of that can be

Time: 8108.76

treated with it used to be lasers and

Time: 8111.82

now more commonly is often being treated

Time: 8113.619

with some of the same injectable drugs

Time: 8116.619

that are treating macular degeneration

Time: 8119.92

um but there's still a lot of vision

Time: 8121.78

loss with diabetes and diabetic

Time: 8123.699

retinopathy I think that's an area where

Time: 8126.88

again early screening making sure if you

Time: 8130.239

have diabetes that's that's an

Time: 8132.159

indication where you definitely have to

Time: 8133.9

be going in and getting your at least

Time: 8136.06

annual exam with an eye care provider or

Time: 8139.36

having someone take a photograph of the

Time: 8141.219

inside of your eye and rate that

Time: 8143.26

photograph to say if you have any

Time: 8144.52

diabetic retinopathy or not

Time: 8146.8

in terms of interventions can we talk

Time: 8149.199

about diabetic retinopathy first because

Time: 8151.179

of course type 1 diabetes is a failure

Time: 8153.46

to produce insulin relatively rare

Time: 8156.52

compared to type 2 diabetes which as you

Time: 8158.56

mentioned is proliferating in developing

Time: 8161.619

countries right this is probably

Time: 8163.86

unprecedented in the sense that

Time: 8166.239

developing countries have better Medical

Time: 8168.699

Care typically than non-developed

Time: 8170.32

countries

Time: 8171.36

more opportunities for food nourishment

Time: 8174.52

and yet it's clearly a problem of

Time: 8177.28

overnourishment insulin insensitivity

Time: 8179.679

obesity Etc

Time: 8181.9

is this type of diabetic retinopathy

Time: 8184.48

that one observes the same for type 1

Time: 8188.44

diabetics versus type 2 diabetics

Time: 8190.42

because my understanding is that type 2

Time: 8191.98

diabetes this insulin insensitivity is

Time: 8196.359

a bit of a Continuum right I mean the

Time: 8198.76

type 1 diabetes is as far as I know is

Time: 8201.219

all or none you either make insulin or

Time: 8202.78

you don't but type 2 diabetes someone

Time: 8204.639

could be mildly in insulin insensitive

Time: 8207.76

or severely insulin insensitive and

Time: 8210.219

sometimes I'm told people are not

Time: 8212.74

necessarily obese and can have type 2

Time: 8215.019

diabetes as well certainly things like

Time: 8217.42

smoking and alcohol intake can

Time: 8219.099

contribute to that so how equivalent are

Time: 8222.76

type 1 and type 2 diabetes when framed

Time: 8225.219

Under the Umbrella of diabetic

Time: 8227.5

retinopathy yeah the the time to

Time: 8230.92

presentation can be different

Time: 8233.5

a type 1 diabetic usually presents with

Time: 8237.399

sort of a

Time: 8238.5

cataclysmic sudden loss sudden sort of

Time: 8242.08

final loss of their ability to make

Time: 8243.76

insulin it usually presents in childhood

Time: 8246.58

or teenage years but can present you can

Time: 8249.16

have late onset type 1 diabetes because

Time: 8252.099

it's kind of a sudden presentation it

Time: 8255.58

can take some years after that to show

Time: 8259.179

any diabetic retinopathy whereas just

Time: 8261.82

because just just like you said type 2

Time: 8264.519

diabetes can be on a Continuum and

Time: 8266.26

people can have like kind of a mild type

Time: 8268.24

2 diabetes but kind of be you know

Time: 8270.34

getting along you know going through

Time: 8272.439

life kind of maybe not even realizing

Time: 8274.54

you know at first and so when you're

Time: 8276.939

diagnosed with type 2 diabetes you've

Time: 8279.219

probably had some insulin resistance for

Time: 8282.639

the years prior to your diagnosis and so

Time: 8285.46

in that case you often can have

Time: 8288.04

um you know like you're you're at higher

Time: 8289.479

risk for presenting sooner with the

Time: 8292.359

complications of diabetes like diabetic

Time: 8295.24

retinopathy now given that the actual

Time: 8299.519

retinopathy

Time: 8301.059

is very similar maybe the same uh

Time: 8303.88

between type 1 diabetes and type 2

Time: 8305.979

diabetes and again it involves things

Time: 8308.8

like leaky blood vessels new blood

Time: 8311.2

vessel growth there's some amount of

Time: 8313.24

neurodegenerative dysfunction that just

Time: 8315.099

simply occurs uh so so uh you can have

Time: 8318.34

little little hemorrhages or bleeding

Time: 8320.559

spots in the retina tiny little strokes

Time: 8323.38

or microvascular uh events in the retina

Time: 8326.439

so that can happen in either type 1 or

Time: 8329.32

type 2 diabetes once you start having

Time: 8331.479

the retinopathy it does look pretty

Time: 8333.219

similar

Time: 8334.3

so what can people do to prevent or

Time: 8338.5

treat diabetic retinopathy obviously the

Time: 8340.54

type 1 diabetic needs to take insulin in

Time: 8343.12

order to survive really type 2 diabetics

Time: 8345.82

need to get their obesity under control

Time: 8347.5

if they are in fact obese and get their

Time: 8350.62

blood sugar levels under control

Time: 8352.32

regardless that's my understanding and

Time: 8356.099

by extension are you seeing any

Time: 8359.679

reductions in diabetic retinopathy with

Time: 8362.26

people that are taking these glucose

Time: 8364.24

like peptide mimics like ozempic which

Time: 8367.42

is used to treat type 2 diabetes yeah

Time: 8369.76

it's been a very exciting development

Time: 8371.559

for the diabetes field this new class of

Time: 8374.559

of um of

Time: 8377.16

anti-diabetic drugs and

Time: 8380.559

um so uh there you've touched on a

Time: 8383.139

couple of them there are a few key

Time: 8385.3

things for reducing the risk of diabetes

Time: 8388.96

or the impact of an diabetes on your

Time: 8391.18

retina at risk of diabetic retinopathy

Time: 8394.3

or impact of diabetes on your retina

Time: 8397.359

uh one is as I mentioned get regular eye

Time: 8400.18

exams be screened you know any diabetic

Time: 8402.76

should be screened at least once a year

Time: 8404.62

uh with a with a good comprehensive

Time: 8407.62

retinal exam looking for any of these uh

Time: 8410.74

items the number one most important

Time: 8414.34

element to prevent diabetic retinopathy

Time: 8417.34

is to control your diabetes and having a

Time: 8420.82

real good blood sugar control keeping

Time: 8422.859

your hemoglobin A1c which is one of the

Time: 8425.02

blood tests that gets used to measure

Time: 8426.939

how your kind of long-term diabetes

Time: 8428.859

management is going

Time: 8430.479

uh that's really uh you know first and

Time: 8434.2

foremost the most important and that's

Time: 8436.359

been shown in large clinical trials they

Time: 8438.64

actually randomize patients to hey take

Time: 8441.22

care of your diabetes or do a real good

Time: 8443.92

job taking care of your diabetes and the

Time: 8446.14

patients who did a real good job taking

Time: 8448

care of their diabetes have much less

Time: 8450.28

diabetic retinopathy so that's number

Time: 8452.859

one it turns out that if you have high

Time: 8456.04

blood pressure and diabetes that blood

Time: 8459.64

pressure is also really damaging to your

Time: 8463.6

retina also by the way the kidneys and

Time: 8465.52

probably all the other organs that are

Time: 8467.2

suffering from the diabetic insult so in

Time: 8470.14

addition to controlling blood sugar

Time: 8471.66

really important to have blood pressure

Time: 8474.1

under great control now both blood sugar

Time: 8477.34

and blood pressure in type 2 diabetics

Time: 8479.859

especially if you're catching them early

Time: 8481.8

can be improved with some of these you

Time: 8485.38

know so-called Lifestyle Changes like

Time: 8487.359

improving eating watching what your food

Time: 8489.88

intake is you know getting good exercise

Time: 8492.42

trying to lose weight uh so these are

Time: 8496.54

definitely on that list of how do you

Time: 8499.359

get to good blood sugar and blood

Time: 8501.28

pressure control

Time: 8502.96

but suffice it to say blood sugar and

Time: 8506.38

blood pressure control right at the top

Time: 8508.5

and then also including the regular at

Time: 8512.02

least annual exams and then if diabetic

Time: 8514.06

retinopathy is detected and blood sugar

Time: 8517.12

and blood pressure control are not going

Time: 8518.859

to be enough for that patient we do have

Time: 8521.62

treatments as I mentioned before there

Time: 8523.3

are drugs that can be injected if your

Time: 8524.979

retina is getting you know kind of leaky

Time: 8527.2

blood vessels from diabetes there are

Time: 8530.319

treatments that we can give the eye

Time: 8532.66

specifically to try to counter the

Time: 8535.24

diabetic retinopathy terrific in terms

Time: 8538.78

of glaucoma as you mentioned glaucoma is

Time: 8541.96

related to pressure although there is

Time: 8544.78

pressure normal glaucoma

Time: 8547.6

glaucoma is a death of the retinal

Time: 8550.06

ganglion cells the neurons that connect

Time: 8551.74

the eye to the brain and once they are

Time: 8554.2

gone at least at this point in human

Time: 8555.88

history they can't be replaced although

Time: 8558.34

hopefully because of work that you've

Time: 8560.26

done in the other Laboratories are doing

Time: 8561.88

at some point that statement I just made

Time: 8563.859

will not be true in the rgcs can be

Time: 8566.08

replaced

Time: 8567.28

meanwhile what can and should people do

Time: 8571.02

to find out if they have glaucoma

Time: 8574.12

and to treat glaucoma

Time: 8577

and is it true that even if somebody has

Time: 8579.7

normal pressure that lowering their eye

Time: 8582.22

pressure further protects them against

Time: 8584.08

glaucoma yeah that's absolutely right so

Time: 8586.72

most important is to get screened with a

Time: 8589.42

formal exam at your optometrist or

Time: 8592.42

ophthalmologist because you you won't

Time: 8594.819

notice you won't have any symptoms if

Time: 8597.819

your eye pressure is too high you won't

Time: 8599.92

know you're not likely to notice until

Time: 8601.899

very late in the disease if your

Time: 8604.06

peripheral vision is being damaged

Time: 8606.22

through the course of glaucoma so most

Time: 8608.859

important us have a screening exam a

Time: 8610.78

good comprehensive screening exam will

Time: 8612.819

always include checking the eye

Time: 8614.979

pressures and also looking in the back

Time: 8617.439

of your eye the head of the optic nerve

Time: 8620.38

where all the fibers leave the eye and

Time: 8622.12

carry the optic nerve information back

Time: 8624.04

to the brain we can see that when we

Time: 8626.14

look inside your eye and uh and and

Time: 8628.66

glaucoma has a fairly characteristic

Time: 8631.42

look to it in the optic nerve head so so

Time: 8634.54

looking at the optic nerve had uh we

Time: 8637.479

have Imaging and peripheral vision

Time: 8639.64

testing that can also be included in

Time: 8641.92

those screening exams so if you really

Time: 8644.2

get a comprehensive screening exam you

Time: 8646.24

can very reliably detect if you have

Time: 8648.88

glaucoma to worry about or you're in the

Time: 8651.22

clear

Time: 8652.18

if you have glaucoma to worry about we

Time: 8654.34

have treatments and you're absolutely

Time: 8655.72

right whether you start with a

Time: 8657.58

abnormally high pressure or you start

Time: 8659.92

with a pressure that's on the face of it

Time: 8662.08

in the normal range

Time: 8664.24

in either case lowering the pressure has

Time: 8666.7

been shown in large properly controlled

Time: 8669.88

clinical trials to slow the progression

Time: 8673.18

of optic nerve damage and vision loss so

Time: 8677.26

absolutely in either case starting with

Time: 8680.14

high pressure or starting with normal

Time: 8681.52

pressure in either case you've got to

Time: 8683.62

lower the pressure further and as I

Time: 8685.84

mentioned we have eye drops those are

Time: 8687.58

usually the first line there's very good

Time: 8689.68

data that there's a very benign

Time: 8692.02

non-invasive laser it's not the same

Time: 8694.12

kind of laser that gets used for Lasik

Time: 8695.92

but there's a benign very safe type of

Time: 8698.56

laser called selective laser

Time: 8701.16

trabeculoplasty SLT we call it and

Time: 8704.56

that's also very effective as a first

Time: 8706.54

line actually in the largest clinical

Time: 8708.7

trial from which the data have been

Time: 8711.34

coming out just even over the last few

Time: 8712.84

years it's called the light trial in the

Time: 8715.42

light trial patients with glaucoma were

Time: 8717.939

randomly assigned to either get the

Time: 8719.74

laser or the sort of most common first

Time: 8722.62

strongest eye drop and uh that gets used

Time: 8726.52

clinically and actually

Time: 8729.22

on many features they both worked at

Time: 8731.74

least as well but when looking out over

Time: 8734.02

the long term actually the laser had

Time: 8735.88

some advantages over the eye drop not in

Time: 8738.52

the least of which by the way it's very

Time: 8739.96

nice for patients to not have to like

Time: 8741.46

remember to use the eye drop every night

Time: 8743.439

and so um so that's quite helpful I

Time: 8745.78

think uh to to keep in mind as a

Time: 8748.3

treatment option uh early in the course

Time: 8750.46

of the disease of course if the eye

Time: 8752.8

drops under our lasers are not enough

Time: 8755.14

early in the disease we also have

Time: 8756.939

surgical approaches to lower the eye

Time: 8758.92

pressure further you know even with all

Time: 8761.979

of our treatments all of these

Time: 8764.2

treatments stepping patients through all

Time: 8766.18

of this

Time: 8767.92

about 10 15 even 20 percent of patients

Time: 8771.04

will lose very meaningful functional

Time: 8773.26

vision and maybe five ten fifteen

Time: 8775.78

percent of patients especially depending

Time: 8777.52

where you are in the world will go blind

Time: 8780.22

from glaucoma

Time: 8781.92

including in you know quote-unquote

Time: 8785.14

developed countries uh there's still a

Time: 8788.319

very significant cohort of patients that

Time: 8791.08

go blind legally blind and then you know

Time: 8794.08

absolute blindness I can't even tell if

Time: 8796.3

the lights are on in the room uh so it's

Time: 8799

it's it's it's devastating it's

Time: 8801.16

Insidious it's hard to detect early

Time: 8805.18

um and so glaucoma's still a tough one

Time: 8807.399

even with all of the treatments that we

Time: 8809.859

have okay so get your pressures checked

Time: 8812.08

folks and if you are prescribed drops

Time: 8815.319

take your drops

Time: 8817.12

I hear about patients not taking their

Time: 8818.979

drops which to me just seems like

Time: 8821.08

baffling but I guess having to do

Time: 8824.56

something day in and day out is it can

Time: 8826.72

be Troublesome enough that unless people

Time: 8828.939

are losing their Vision very quickly or

Time: 8830.5

they are very afraid of losing their

Time: 8831.88

Vision sometimes they just neglect to

Time: 8833.319

take them it's hard it's hard for

Time: 8835.18

glaucoma eye drops it's hard for taking

Time: 8837.22

your blood pressure medication it's hard

Time: 8839.14

for a lot of medicines you know if

Time: 8840.52

you're if you're taking a medicine where

Time: 8842.08

you don't feel better you know if you

Time: 8843.819

have a headache and you take an aspirin

Time: 8846.04

or Tylenol or an ibuprofen uh you know

Time: 8849.22

you feel better you feel reinforced gosh

Time: 8851.74

taking that pill made sense right but if

Time: 8854.74

you're using an eye drop that like hey

Time: 8856.42

this is going to protect you for the

Time: 8857.92

next 20 years from losing your vision

Time: 8859.78

but you don't notice every day that

Time: 8862.54

anything's better and by the way the eye

Time: 8864.399

drops could be a little irritating maybe

Time: 8866.08

it stings a little for a minute or two

Time: 8867.76

and you put it in your eye some people

Time: 8869.08

are even less tolerant of the eye drops

Time: 8871.479

it's hard to feel motivated every day

Time: 8873.64

and we know that we call that compliance

Time: 8875.56

we know that it's very hard for patients

Time: 8877.42

to stay compliant with prescribed

Time: 8880.3

medications where they don't feel or

Time: 8883.12

notice a difference in a daily way

Time: 8887.319

I realize that we can't stop aging

Time: 8890.2

yet

Time: 8891.7

um but right now you can't stop aging

Time: 8893.319

and age is a risk factor for glaucoma my

Time: 8896.08

understanding is so is smoking or vaping

Time: 8900.58

nicotine

Time: 8902.02

and so is alcohol

Time: 8905.5

and by that reasoning should people

Time: 8908.74

strive to drink less and smoke less

Time: 8910.899

including vaping nicotine less if they

Time: 8913.359

are concerned about glaucoma yeah and

Time: 8916.06

not just glaucoma macular degeneration

Time: 8917.859

actually macular degeneration has a

Time: 8920.02

couple major risk factors macular

Time: 8922.18

degeneration aging just like with

Time: 8924.399

glaucoma major risk factor

Time: 8927.22

smoking including exposure to secondhand

Time: 8930.34

smoke major risk factor for macular

Time: 8932.74

degeneration and for the progression and

Time: 8934.84

vision loss potentially associated with

Time: 8936.939

macular degeneration in the case of

Time: 8938.92

macular degeneration there's also a

Time: 8940.3

couple of genes that we've sequenced the

Time: 8942.1

human genome and there's a couple of

Time: 8943.6

genes associated with magnet generation

Time: 8945.52

two

Time: 8946.66

that's less true for your typical

Time: 8948.399

run-of-the-mill adult Kuma there are

Time: 8950.62

genes for the Pediatric and infantile

Time: 8952.479

forms of glaucoma uh so yeah smoking a

Time: 8956.2

hundred percent including vaping uh it's

Time: 8959.319

a No-No for your eyes just like it's a

Time: 8961.18

No-No for the rest of your body and uh

Time: 8963.58

it's tough as the eye doctor to have

Time: 8965.74

these conversations with patients

Time: 8967.42

because you kind of feel like well you

Time: 8969.52

know they must know it already and I'm

Time: 8972.16

trying to be the good guy in the room

Time: 8973.72

with the patient convince them to use

Time: 8975.22

their other medications but it's it's

Time: 8977.859

important for us also as Eye Care

Time: 8979.899

Providers to reinforce the message with

Time: 8982.359

our patients a smoking terrible idea uh

Time: 8986.2

for maca degeneration also for glaucoma

Time: 8989.02

you know glaucoma is interesting because

Time: 8991

the optic nerve where it degenerates

Time: 8992.979

kind of right at the head of the optic

Time: 8994.54

nerve where it exits the eye it's what

Time: 8997.24

we call a watershed Zone it's kind of an

Time: 8999.34

edge of two blood vessel supplies and if

Time: 9003.6

either of those blood vessels supplies

Time: 9005.399

are a little bit short on blood or

Time: 9007.8

oxygen supply to that optic nerve head

Time: 9009.899

your glaucoma is going to get worse your

Time: 9012.3

optic nerve is going to be under fed and

Time: 9014.22

that's going to worsen this degenerative

Time: 9015.899

process just by not having all the right

Time: 9017.76

nutrients and oxygen so the other thing

Time: 9020.64

is that especially for glaucoma

Time: 9022.74

everything that we talk about for being

Time: 9025.08

heart healthy

Time: 9027

for the rest of our body is is almost

Time: 9030

certainly true for glaucoma and so I

Time: 9032.819

also always counsel glaucoma patients

Time: 9034.859

it's not just no smoking but eat healthy

Time: 9037.68

have a multivitamin uh get some exercise

Time: 9040.979

all those things that are good for your

Time: 9042.84

cardiovascular system are going to be

Time: 9044.939

good for your eyes in general and in

Time: 9046.56

particular if you have glaucoma or at

Time: 9050.22

risk high risk for glaucoma I realize

Time: 9053.16

that smoking or vaping are problematic

Time: 9055.92

for glaucoma and for macular

Time: 9057.78

degeneration but we can't have a

Time: 9059.7

conversation about glaucoma without at

Time: 9061.439

least mentioning cannabis I did an

Time: 9063.66

entire episode about cannabis which

Time: 9065.16

touched on some of the real dangers of

Time: 9067.26

very high THC concentration cannabis

Time: 9069.6

this lost me a few

Time: 9071.64

um followers I'm sure no problem because

Time: 9074.22

what was important was to convey the

Time: 9076.62

fact that the Cannabis that's out there

Time: 9079.38

nowadays comes in a variety of different

Time: 9081.42

strains and ratios of THC to CBD there's

Time: 9085.26

some severe risks of high THC especially

Time: 9088.08

in young males although not always the

Time: 9091.14

point being that there are and I want to

Time: 9093.6

be very clear about this because for

Time: 9095.04

whatever reason cannabis gets people

Time: 9096.359

really up in arms they always say it's

Time: 9097.74

not as bad as alcohol but guess what we

Time: 9099.3

did an entire episode about alcohol and

Time: 9100.92

there the message is very clear zero is

Time: 9102.72

better than any and two a week is

Time: 9104.52

probably the limit and if you're an

Time: 9105.899

alcoholic zero is the rule so

Time: 9109.68

with cannabis it's clear by my read of

Time: 9113.58

the data that it can lower eye pressure

Time: 9115.979

which may undermine the progression of

Time: 9118.439

glaucoma somewhat but if people are

Time: 9120.479

smoking that cannabis is it therefore

Time: 9122.64

going to offset any gain that one would

Time: 9124.56

get from that cannabis and then how does

Time: 9127.26

one account for the potentially

Time: 9129.12

problematic aspects of very high THC

Time: 9131.88

cannabis yeah it's a great question and

Time: 9134.46

the truth is is that in most patients

Time: 9136.68

cannabis will lower the eye pressure the

Time: 9140.399

problem is is it really only lowers that

Time: 9142.859

eye pressure During the period that

Time: 9144.899

you're high from the Cannabis and the

Time: 9147.18

second problem is that smoking version

Time: 9150

of getting that cannabis into your

Time: 9152.16

system the smoking is bad for your lungs

Time: 9154.859

by the way the smoke from Cannabis or

Time: 9157.74

from cigarettes is also terrible for

Time: 9160.5

your dry eyes it causes inflammation it

Time: 9163.859

dries out your eyes so it's also very

Time: 9166.439

bad from that perspective now so the the

Time: 9169.859

problem with cannabis is not that it

Time: 9171.42

doesn't work to lower the price we want

Time: 9172.979

to lower the pressure that's great the

Time: 9174.78

problem with cannabis is that it's not

Time: 9176.76

realistic for most of our patients

Time: 9179.76

to prescribe could you go out and be

Time: 9182.28

high from Cannabis 24 hours a day seven

Time: 9185.1

days a week for the next 20 years I'm

Time: 9187.56

sure some people have tried and

Time: 9189.12

succeeded

Time: 9190.26

um but right that's not practical for

Time: 9192.3

most people and certainly for young

Time: 9193.74

people it could be really especially

Time: 9195.72

problematic yeah I should say absolutely

Time: 9197.819

so so I recommend not taking that

Time: 9199.979

approach but that said I I'm definitely

Time: 9202.08

not a decryer of it and now that there

Time: 9204.359

are edible forms I certainly have

Time: 9206.7

patients who are using it in a

Time: 9209.399

responsible way uh especially edible

Time: 9212.46

forms and uh and in select cases like

Time: 9215.58

that could make the difference for them

Time: 9217.2

helping to keep the pressure down and

Time: 9218.939

I'll say for example you know it turns

Time: 9220.979

out you've talked a lot over the last

Time: 9223.26

couple years about diurnal curves and

Time: 9225.6

circadian rhythms it turns out that our

Time: 9228.54

eye pressure also undergoes a circadian

Time: 9231.3

rhythm and it's actually highest at

Time: 9233.46

night while we're sleeping kind of peaks

Time: 9235.8

in those early morning hours then hits a

Time: 9237.78

low throughout the early day and then

Time: 9239.46

kind of rises again throughout the

Time: 9241.2

afternoon into the evening and we have a

Time: 9243.96

lot of patients who they come into their

Time: 9245.34

Clinic visit their eye pressure looks

Time: 9246.96

normal but it's actually quite a bit

Time: 9248.52

higher when they're at home and that

Time: 9250.02

could explain some fraction of what we

Time: 9252.6

call normal pressure glaucoma it just

Time: 9254.58

looks normal during the day it's

Time: 9255.66

actually high at night and so in

Time: 9258.24

particular some patients I certainly

Time: 9259.8

have some patients who are using these

Time: 9261.66

products like let's say before bed and

Time: 9264.72

if it's controlling their eye pressure

Time: 9266.399

at night while they're asleep when the

Time: 9268.14

eye pressure would have been the highest

Time: 9269.76

it may confer some protective advantage

Time: 9272.76

over time but that said again like for

Time: 9275.34

most patients it's not going to be the

Time: 9276.84

primary approach I'm most excited about

Time: 9279.12

the idea of

Time: 9280.939

you know Laboratories or companies

Time: 9283.5

figuring out which

Time: 9285.359

the compounds Within These cannabinoids

Time: 9289.56

they're called within these products are

Time: 9292.08

actually responsible for lowering the

Time: 9294.359

eye pressure and could we get like a

Time: 9296.58

more potent eye specific

Time: 9299.78

long-acting drug that's basically

Time: 9302.64

derived from the concept of cannabis but

Time: 9305.58

works better and is more compatible with

Time: 9308.1

not bringing along all the other adverse

Time: 9310.8

elements that can come with cannabis use

Time: 9313.68

you mentioned the Circadian rhythm and

Time: 9315.84

eye pressure and the fact that eye

Time: 9318.12

pressure is higher at night

Time: 9319.92

is there any advantage to sleeping in a

Time: 9323.16

particular position I know this might

Time: 9324.66

sound a little detailed but I seem to

Time: 9326.1

recall an abstract or a paper a few

Time: 9327.96

years ago at a meeting that you and I

Time: 9329.28

both attended were that said that if

Time: 9331.319

people slept with their head below their

Time: 9333.12

feet eye pressures were higher than if

Time: 9335.399

their head was slightly elevated above

Time: 9336.899

their feet and for somebody who has

Time: 9338.399

glaucoma this could make a pretty

Time: 9340.26

substantial difference in terms of their

Time: 9341.7

eye pressures at precisely the hours of

Time: 9343.979

the night we should say in which they

Time: 9346.8

could be doing the most damage to the

Time: 9348.12

ganglion cells yeah absolutely and we

Time: 9351.3

will sometimes counsel patients with

Time: 9353.46

severe glaucoma especially if they're

Time: 9355.68

you know poorly responsive to standard

Time: 9357.96

therapies or poorly able to tolerate

Time: 9360.72

standard therapies we'll counsel them if

Time: 9363.3

they're able to sleep up on a couple

Time: 9364.92

pillows get kind of a 30 degree sleep

Time: 9367.08

angle going what I don't want to do is

Time: 9370.2

interfere with a person's sleep because

Time: 9372.18

I just I fundamentally feel for the

Time: 9374.28

total health of the whole human being

Time: 9377.7

getting a good night's sleep is maybe

Time: 9380.34

more important than that 30 degrees and

Time: 9382.2

if trying to sleep up on pillows at 30

Time: 9384.12

degrees it's going to lead to kind of

Time: 9385.92

restless difficult sleep night I'd

Time: 9388.26

rather the patient get a good night's

Time: 9390.72

sleep but if they can tolerate it and

Time: 9392.939

especially if they have a sort of a

Time: 9394.62

tough version of glaucoma then we'll

Time: 9397.74

we'll let them try see if they can sleep

Time: 9399.78

up the other really interesting question

Time: 9401.88

that arises is uh does which side you

Time: 9405.06

sleep on affect uh which I might have

Time: 9408.54

worse glaucoma glaucoma is almost always

Time: 9410.88

with with a few rare exceptions almost

Time: 9413.22

always a disease of two eyes but it can

Time: 9415.979

present very asymmetrically in fact it's

Time: 9418.2

quite common to have one eye kind of

Time: 9420.24

have worse damage than the other and and

Time: 9422.28

we don't know fundamentally why that is

Time: 9424.2

but one hypothesis was gosh maybe if you

Time: 9427.02

sleep on the right eye uh then your

Time: 9429.899

right eye will have worse glaucoma

Time: 9431.399

because the pressure is a little higher

Time: 9432.78

down below or maybe it's pressing on the

Time: 9435.899

pillow in a way or some something like

Time: 9438.3

that there have been a couple studies

Time: 9439.979

really really looking at that question a

Time: 9442.859

couple Studies have said the lower aisle

Time: 9444.84

have worse glaucoma a couple Studies

Time: 9446.7

have said the higher I will have worse

Time: 9448.439

glaucoma so the upshot is it probably

Time: 9450.6

doesn't matter which side you sleep on

Time: 9452.16

we also know when you video people in

Time: 9454.8

their normal sleep pattern even if you

Time: 9456.72

feel you always fall asleep on the left

Time: 9459.06

side of your face people toss and turn

Time: 9461.58

all night probably over the course of

Time: 9463.2

the night you're spending a similar

Time: 9464.76

amount of time on each eye I'm glad you

Time: 9467.88

brought up that point in terms of

Time: 9469.56

macular degeneration I'm curious about

Time: 9471.899

the things that people can do as opposed

Time: 9474.359

to the don'ts in order to perhaps offset

Time: 9477.24

macular degeneration one of the things

Time: 9478.859

that I'm intrigued by are the results of

Time: 9480.359

Glenn Jeffery's laboratory over at

Time: 9482.04

University College London I had known

Time: 9483.78

Jeff for probably a decade or more and

Time: 9486.96

he typically worked on animal models but

Time: 9489.54

then a few years ago started publishing

Time: 9491.04

studies I believe there are now two

Time: 9492.72

published studies showing how red light

Time: 9494.88

exposure

Time: 9496.319

and near infrared

Time: 9498.359

light exposure done early in the day to

Time: 9501.359

the eye at a distance of about two feet

Time: 9503.22

for just a couple of minutes a few times

Time: 9505.5

a week could offset some of the vision

Time: 9508.979

loss associated with age-related macular

Time: 9510.84

degeneration in people older than 40.

Time: 9513.3

that's my understanding of these studies

Time: 9514.68

and there's a theory there about

Time: 9515.939

enhancing function of mitochondria and

Time: 9517.979

photoreceptors by reducing reactive

Time: 9519.66

oxygen species there's a whole

Time: 9520.92

mechanistic hypothesis but

Time: 9523.8

my question is is that the sort of

Time: 9526.5

protocol that produces significant

Time: 9528.899

enough offset of macular degeneration

Time: 9531.3

like we should all be looking at red

Time: 9532.859

lights in the morning

Time: 9534.42

um or is it still too early days in

Time: 9537.12

order to really conclude that

Time: 9540.42

data is very compelling the data are

Time: 9543.12

very compelling that this kind of red or

Time: 9546.359

near infrared light therapy can be at

Time: 9549.6

some level neuroprotective and yes uh

Time: 9551.76

the the data suggests that uh kind of

Time: 9555.479

ramping up high high functioning

Time: 9558.24

mitochondria is a part of that

Time: 9560.3

activating neuroprotective Pathways in

Time: 9562.92

the retina it's actually been

Time: 9564.54

demonstrated in animal models and a

Time: 9567.06

little human data here and there but

Time: 9568.859

both for macular degeneration kind of uh

Time: 9571.62

degenerative is but also for optic

Time: 9574.02

neuropathies you know like glaucoma

Time: 9576.24

retinal ganglion cells the cells that

Time: 9578.58

carry all that visual information from

Time: 9580.26

the eye to the brain they're chock full

Time: 9582.06

of mitochondria too and uh and so the

Time: 9585.359

idea that this could be a therapeutic

Time: 9587.52

approach I think is very compelling

Time: 9589.62

there are a number of studies actually I

Time: 9591.42

think still ongoing today

Time: 9593.64

really trying to figure out what's the

Time: 9595.439

right dose how much brightness do you

Time: 9597.96

need is there an optimal wavelength how

Time: 9600.06

many minutes does it matter when during

Time: 9602.28

the day you provide that light or how

Time: 9605.7

many minutes or hours

Time: 9607.92

um these are still very much open

Time: 9610.02

questions you know what's the dose

Time: 9611.819

what's the delivery

Time: 9613.8

um but it's it's it's it's it's very

Time: 9616.439

promising looking and there's biological

Time: 9618.479

premise and I'm excited to see where

Time: 9620.76

that goes because again that's like a

Time: 9622.439

that's a very accessible uh sort of

Time: 9625.979

therapeutic approach that could be

Time: 9627.96

brought to a very broad swath of of

Time: 9630.359

people so I'm excited about that sorry I

Time: 9633.66

didn't mean to interrupt and completely

Time: 9634.92

non-invasive

Time: 9636.42

um I should um probably mention a

Time: 9639.12

warning which is if people are going to

Time: 9640.8

decide that they're going to jump on

Time: 9642.54

this result and do red light exposure in

Time: 9644.399

the early part of the day no matter what

Time: 9646.56

color a light is if it's too bright you

Time: 9648.899

can damage your eye so I think this is

Time: 9651.12

why you're pointing the fact that we

Time: 9652.319

need established protocol calls before

Time: 9655.38

people really start blasting their eyes

Time: 9657

with red light and if they are going to

Time: 9658.56

expose themselves to Red Light it

Time: 9660

shouldn't be uncomfortably bright do I

Time: 9661.859

have that yeah that's absolutely right

Time: 9663.12

you know actually uh light effect

Time: 9666.18

um we talked about this a little bit

Time: 9667.38

earlier

Time: 9668.88

um there's actually now data also that

Time: 9671.1

red light and actually interestingly

Time: 9673.92

studies using light at the other end of

Time: 9676.2

the visible spectrum violet light either

Time: 9678.84

of those in small daily doses can also

Time: 9682.62

be used to prevent progression of

Time: 9685.02

nearsightedness in children in

Time: 9687.06

school-aged children and so I think

Time: 9689.939

we're really just on the cusp of really

Time: 9691.56

understanding the biology of how these

Time: 9694.14

different light therapies might be

Time: 9696.84

leveraged maximally to to maximize our

Time: 9700.02

Eye Health and both during development

Time: 9702.72

and at the other end of the spectrum as

Time: 9705.06

we age so it's an exciting area and I

Time: 9708.3

think this kind of phototherapy is uh

Time: 9710.64

you know a very hot topic for research

Time: 9713.76

right now very hot topic one has to

Time: 9716.04

wonder whether or not these light

Time: 9717.12

therapies the fact that infrared works

Time: 9719.819

and maybe ultraviolet works is are

Time: 9722.58

really just capturing some of what

Time: 9724.02

sunlight

Time: 9725.04

is naturally doing when as you mentioned

Time: 9728.34

before a child or perhaps an adult also

Time: 9730.56

spends a certain number of hours

Time: 9731.64

outdoors I mean maybe we're just filling

Time: 9733.319

in the blanks that are neglected

Time: 9735.12

nowadays because we're spending so much

Time: 9736.5

time indoors under artificial lights and

Time: 9738.18

in front of screens yeah yeah

Time: 9740.6

very thoughtful possibility yeah

Time: 9743.58

I have a couple of we don't have to call

Time: 9745.5

them quick questions but common

Time: 9747.3

questions that perhaps have a brief uh

Time: 9751.08

explanations uh for instance I put out a

Time: 9754.439

request for questions in an anticipation

Time: 9756.78

of this episode and I got a lot of

Time: 9758.58

people asking what are floaters in the

Time: 9761.64

eye and is there anything that people

Time: 9763.26

can do to get rid of floaters yeah our

Time: 9766.439

eye when we're born is actually filled

Time: 9768.6

in the middle of it with a jelly it's

Time: 9770.64

not just fluid it's kind of a jelly

Time: 9772.38

there's collagen fibers and thankfully

Time: 9774.96

the whole jelly is largely invisible so

Time: 9778.26

the light can get through our eye back

Time: 9779.819

to the retina without being impeded as

Time: 9783.06

we age those different fibers and gels

Time: 9786.439

shrink and contract and they peel off of

Time: 9791.58

the back of the retina so there's just

Time: 9793.08

in the middle now your your eyeball

Time: 9794.939

doesn't shrink because it fills in with

Time: 9797.04

with fluid with salt water basically but

Time: 9799.92

the gel part shrinks and as it shrinks

Time: 9802.5

and also pulls peels off the retina it

Time: 9806.64

can pull off kind of little tiny retinal

Time: 9808.68

bits not important to your vision bits

Time: 9811.14

but just like little tissue bits and

Time: 9813.06

also as it congeals it kind of uh can

Time: 9815.16

get little concretions in the jelly and

Time: 9818.46

we perceive those as floaters you know

Time: 9821.1

little almost semi-translucent or in

Time: 9823.5

some cases kind of grayish blackish

Time: 9826.2

sometimes sometimes you get a big one if

Time: 9828.24

it peels off the edge of the optic nerve

Time: 9830.28

in the back of the eye as happens we

Time: 9832.14

call that a posterior vitreous

Time: 9833.939

detachment you can actually see like a

Time: 9835.92

moon or a half moon floater in Your

Time: 9838.5

Vision these are very frustrating to a

Time: 9842.819

lot of people

Time: 9844.38

um and uh the good news is in almost all

Time: 9847.92

cases they will just go away by

Time: 9849.42

themselves in theory it's been played

Time: 9852.359

with gosh we could do like a big surgery

Time: 9854.819

to chew up all that jelly replace it all

Time: 9857.76

with salt water try to get rid of your

Time: 9859.62

floaters there's risk associated with

Time: 9862.02

that surgery we use it very effective

Time: 9863.58

actively in a retinal detachments or

Time: 9866.04

other diseases bad diabetic retinopathy

Time: 9868.62

bleeding inside the eye we can take out

Time: 9871.2

the jelly from the eye replace it with

Time: 9872.819

with salt water but that's not

Time: 9876.479

um you know putting patients through the

Time: 9878.76

risk of that surgery just to get rid of

Time: 9880.979

a couple of floaters or a few floaters

Time: 9882.72

that probably are going to go away over

Time: 9885.66

the next few months I actually like to

Time: 9888

tell patients it's nothing to worry

Time: 9890.399

about just ignore them and actually if

Time: 9893.819

you stop focusing on them your brain

Time: 9895.92

will actually start filtering them out

Time: 9897.96

you'll stop noticing them if you can

Time: 9900.78

kind of uh not worry about them be a

Time: 9903.6

little intentional about ignoring them

Time: 9905.399

in the beginning and then they do

Time: 9906.96

actually go away and look some will go

Time: 9908.939

away these three will go away these two

Time: 9910.68

will appear eventually you'll stop

Time: 9913.62

having floaters most patients will stop

Time: 9915.6

having floaters so we really don't like

Time: 9919.14

to put a patient at risk by intervening

Time: 9921.42

we really like to in this case just

Time: 9923.16

reassure them it's going to be okay just

Time: 9925.5

ignore them they'll eventually go away

Time: 9927.359

thank you for that answer

Time: 9930.479

twitching of the eye is something that

Time: 9933.18

people complain about I know when I get

Time: 9934.8

tired I'll get a twitch over one eye I

Time: 9937.439

think there's a condition is it called

Time: 9939

myasthena gravis where people go through

Time: 9941.76

a stressful period or get very fatigued

Time: 9943.5

and I think that's a depletion of the

Time: 9945.42

nerve terminal communication between the

Time: 9948.42

nerves that control the muscles of the

Time: 9950.1

eye and then people get this kind of

Time: 9951.3

like hooded eye look

Time: 9953.28

um where they have a hard time opening

Time: 9955.08

their eyes but barring something extreme

Time: 9957.479

like myasthena gravis

Time: 9959.28

or staying up for two days working or

Time: 9962.64

even just being a bit sleep deprived

Time: 9964.8

what causes the twitching of the eyelid

Time: 9966.78

and is there anything people can do

Time: 9968.04

about that most the time it's actually

Time: 9970.26

just a bad nerve ending you know maybe

Time: 9972.72

that one nerve cell you know your eyelid

Time: 9975.6

is fed by you know hundreds maybe it's

Time: 9979.02

thousands of nerve cells that are doing

Time: 9981.24

the muscles they're doing the feeling

Time: 9982.8

obviously if the ones controlling the

Time: 9984.84

muscles that can lead to a twitch if one

Time: 9987.18

of those nerve cells kind of just starts

Time: 9989.1

you know maybe that one nerve cell is

Time: 9991.68

dying just you know whatever the age you

Time: 9993.66

can process uh you know it happens in

Time: 9996.06

young people too though so you got one

Time: 9998.76

bad fiber that's just deciding to kind

Time: 10001.88

of ring off the hook that's that's that

Time: 10003.8

telephone's just ringing off the hook

Time: 10005.3

and it's just activating the muscle so

Time: 10007.64

you're just twitching that muscle I've

Time: 10010.16

had them as well and you can have

Time: 10011.72

notches in your eyelids you can have

Time: 10013.1

this anywhere in your body like one

Time: 10015.2

little spot on your leg where just the

Time: 10017.899

muscle right under the skin again is

Time: 10019.939

just

Time: 10021.74

and typically it'll happen over the

Time: 10024.26

course of a couple of months

Time: 10026.56

intermittently some days more sometimes

Time: 10029

less maybe it correlates with when

Time: 10030.319

you're tired a little bit sometimes and

Time: 10033.14

then it'll stop that nerve cell will

Time: 10035.06

either reconnect properly and stop doing

Time: 10037.22

that maybe it dies we don't really know

Time: 10039.56

but typically it lasts on that scale now

Time: 10042.8

there are other diseases not just

Time: 10044.78

myasthenia gravis you can have blepharos

Time: 10047

spasm like where you have a chronic

Time: 10048.979

spasming of of certain nerves causing

Time: 10053.18

muscles to spasm and there we we can use

Time: 10056

we can use treatments for example Botox

Time: 10058.399

as a treatment that you know people use

Time: 10061.34

for cosmetic reducing of wrinkles for

Time: 10064.16

example but you know a really good

Time: 10066.26

medical use of Botox is preventing that

Time: 10068.84

blepharospasm and patients can come in

Time: 10070.88

once every three or six months if they

Time: 10072.92

have a really severe spasming version of

Time: 10075.92

what you're describing but the regular

Time: 10077.78

occasional run-of-the-mill lasts a

Time: 10079.88

couple months nothing to worry about it

Time: 10082.34

does not pre-sage anything bad happening

Time: 10084.62

in your future and maybe let it run its

Time: 10087.62

course and you'll be okay great

Time: 10091.28

we've all heard that carrots are good

Time: 10093.859

for our vision which presumably stems

Time: 10096.08

from some peripheral understanding about

Time: 10098.66

the fact that vitamin A is integral to

Time: 10101.66

the photosynthesis pathway of converting

Time: 10103.76

light into electrical and chemical

Time: 10105.38

signals that the rest of the eye brain

Time: 10107.06

can use and yet I'm guessing that there

Time: 10109.939

probably aren't that many people walking

Time: 10111.439

around who are vitamin A deficient

Time: 10113.06

they're probably out there but not that

Time: 10114.979

many especially in developed countries

Time: 10117.62

and in addition in the last really five

Time: 10120.979

years but in particular in the last two

Time: 10123.02

years I've seen a proliferation of

Time: 10125.359

supplements on the market to promote Eye

Time: 10127.76

Health and Longevity of vision

Time: 10130.88

I'd love your thought on this General

Time: 10133.1

theme of nutrition and supplements for

Time: 10137

improving Eye Health or for maintaining

Time: 10139.399

Eye Health and before we started

Time: 10141.68

recording you mentioned that

Time: 10143.14

Ophthalmology or at least Eye Health is

Time: 10145.76

one area of medicine that has a bit not

Time: 10148.7

extensive but a bit of a longer history

Time: 10151.34

of exploring supplementation in rigorous

Time: 10154.28

randomized control trials whereas other

Time: 10157.76

areas of Neuroscience and Neural Health

Time: 10159.92

such as Alzheimer's Etc certainly there

Time: 10162.68

are brain health supplements out there

Time: 10164.06

but there aren't a lot of rigorous data

Time: 10166.04

to support them just yet so what are

Time: 10167.78

your thoughts on nutrition

Time: 10169.7

um aside from the standard thing of you

Time: 10171.859

know people shouldn't be ingesting too

Time: 10173.479

many calories such that they are obese

Time: 10175.1

and diabetic and therefore you know Etc

Time: 10176.96

indirect effects of nutrition

Time: 10179.78

um what are your thoughts on nutrition

Time: 10181.1

and supplementation for Eye Health yeah

Time: 10184.22

you know you're absolutely right and

Time: 10186.5

again in Ophthalmology we actually do

Time: 10188.24

have quite a bit of studies there's been

Time: 10189.92

quite a bit of attention over the years

Time: 10191.54

even over the decades looking at this

Time: 10193.46

question and I think it's worth

Time: 10195.02

highlighting

Time: 10196.34

um a couple of yeses and a couple of

Time: 10198.08

no's

Time: 10199.399

for macular degeneration which we talked

Time: 10201.74

about being an exceedingly common cause

Time: 10204.02

of vision loss there have been two

Time: 10207.939

age-related eye disease studies called

Time: 10211.1

arids age-related eye disease studies

Time: 10213.439

era there is arids and then arids too

Time: 10215.68

and those studies were a large

Time: 10218.74

randomized Trials of using giving giving

Time: 10222.8

patients supplements and in arids it was

Time: 10226.1

vitamin c and e

Time: 10228.02

uh higher dose than would just come in a

Time: 10230.06

multivitamin

Time: 10231.859

zinc and copper

Time: 10234.62

and then also beta-carotene

Time: 10237.26

and beta-carotene is one of these what

Time: 10239.3

are called carotenoids it's a it's a if

Time: 10241.22

you look at the extended family there's

Time: 10242.78

maybe 600 different chemical entities of

Time: 10246.26

these carotenoids and beta-carotene is

Time: 10248.42

one of them that's in the direct pathway

Time: 10250.1

of making vitamin A and so that was the

Time: 10252.2

principle in the Arid study and the Arid

Time: 10255.02

studies showed that patients randomized

Time: 10257.54

to these pills compared to controls it

Time: 10260.66

it did these are antioxidants in part

Time: 10263.3

right in addition to feeding into that

Time: 10265.16

vitamin A pathway and um and the

Time: 10268.399

patients randomized to get that

Time: 10269.96

supplement mixture

Time: 10271.76

showed less progression of their dry

Time: 10275.6

macular degeneration in the moderate to

Time: 10278.18

severe ranges if you had mild macular

Time: 10280.58

degeneration they didn't show a

Time: 10282.439

statistically significant Improvement

Time: 10284.24

but I will say it's my experience you

Time: 10286.88

know myself with patients and and seeing

Time: 10288.92

how the field works you know if you have

Time: 10290.72

mild macular degeneration even though

Time: 10292.28

it's not as clinically proven we're

Time: 10294.02

still often recommending hey if you can

Time: 10296.54

afford that supplement go ahead and buy

Time: 10298.52

that now arids Was Then followed by a

Time: 10301.1

second study arids too also with vitamin

Time: 10303.92

C vitamin E zinc and copper they

Time: 10307.46

actually tested whether a slightly lower

Time: 10309.14

dose of zinc would be as good as a

Time: 10311

higher dose and a lower dose was as good

Time: 10312.8

as a higher dose and then instead of the

Time: 10315.38

beta-carotene they tested against the

Time: 10317.18

beta-carotene they tried two other

Time: 10320.02

carotenoids that are called lutein and

Time: 10322.34

zeaxanthine and and they actually found

Time: 10325.52

head to head that the second the arids

Time: 10329.54

II formula without the beta-carotene and

Time: 10331.76

with the lutein and zeaxanthin that that

Time: 10334.64

formula was even better at slowing dry

Time: 10338.84

macro degeneration in the moderate to

Time: 10341.3

severe population again it's not clear

Time: 10343.279

how much it may help mild back the

Time: 10345.74

generation but in the uh sort of

Time: 10348.02

clinically defined moderate towards

Time: 10350

severe group there was a statistically

Time: 10352.34

significant it reduced it by about 20 25

Time: 10354.819

the progression of your dry Market

Time: 10357.68

generation and you know over a couple of

Time: 10360.14

years 25 five percent you may not notice

Time: 10362.6

but over a couple of decades you know

Time: 10364.46

that could really slow down the

Time: 10366.56

progression of your disease

Time: 10368.359

now it turns out that the beta carotene

Time: 10371.3

they noted a little bit of an increased

Time: 10373.16

cancer risk in the patients in the arids

Time: 10375.92

one who had that beta-carotene mostly in

Time: 10378.319

patients who are smokers

Time: 10380.18

they also noticed in the second one that

Time: 10382.819

if you were already not taking a

Time: 10384.859

multivitamin or not eating a diet that's

Time: 10387.859

already naturally rich in lutein or

Time: 10390.56

zeaxanthin that the effect of that

Time: 10392.84

supplement was even stronger

Time: 10395.359

so it was very strong clinical trial

Time: 10398.779

support for taking what we now use this

Time: 10401.479

arids II supplementation and I'm sure we

Time: 10405.26

can list the formula or put it in the

Time: 10407.06

links under under your podcast uh uh

Time: 10410.479

that that thus really does slow macular

Time: 10413.479

degeneration so that's like a very

Time: 10415.7

strong example of a yes you should do

Time: 10418.52

this

Time: 10419.54

there's one yes brewing in the glaucoma

Time: 10423.859

field right now and that's high dose

Time: 10426.5

vitamin B3 B is in boy three it's also

Time: 10430.52

called in its various forms either

Time: 10432.02

nicotinic acid or nicotinamide uh the

Time: 10436.04

nicotin sounds like nicotine but this is

Time: 10439.22

not a substitute for smoking or vaping

Time: 10441.74

this is a different this is a vitamin

Time: 10443.66

that just has a very similar sounding

Time: 10445.22

name it's in the NAD synthesis pathway

Time: 10447.74

that's exactly right it's in the NAD

Time: 10449.6

pathway NAD is one of the oxidative

Time: 10452.84

stress regulators and energy Regulators

Time: 10455.899

of our cells so it's a very critical

Time: 10458

molecule in the metabolism of our cells

Time: 10460.7

and there was very strong evidence in

Time: 10463.279

pre-clinical models of mice given

Time: 10465.92

glaucoma that manipulating this pathway

Time: 10468.68

and sort of increasing this pathway

Time: 10471.02

could be protective in glaucoma or other

Time: 10474.38

optic neuropathies optic nerve

Time: 10476.42

degenerative diseases and so there have

Time: 10479.24

now been been too limited but randomized

Time: 10483.68

controlled clinical trials one looking

Time: 10486.319

at glaucoma patients looking at their

Time: 10488

visual field so their actual visual

Time: 10489.859

performance and the other looking at the

Time: 10492.319

electrical signals in the eye called an

Time: 10494.439

electroretnogram kind of like an EEG

Time: 10496.46

does for your brain we can do an ERG for

Time: 10499.52

your retina and in both of those trials

Time: 10502.899

high-dose vitamin B3 was a found to be

Time: 10507.26

very safe and B was shown to actually

Time: 10510.439

improve at least in the short term

Time: 10512.319

improve retinal function measured either

Time: 10515

on visual field testing or on the

Time: 10518.54

electro retinogram now this is now

Time: 10521.779

entering

Time: 10523.46

clinical trials large kind of phase 3

Time: 10526.939

style clinical trials actually around

Time: 10529.58

the world it's a very hot topic for

Time: 10531.92

glaucoma the fact that this NAD boosting

Time: 10534.68

supplementation with high-dose vitamin

Time: 10537.08

B3 might be a great approach to helping

Time: 10539.72

protect the nerve in in glaucoma and so

Time: 10544.399

as I say there's there's three or four

Time: 10546.26

large randomized phase three style

Time: 10549.2

clinical trials uh starting now and so

Time: 10552.62

over the next year or two we'll get more

Time: 10554.359

data but I'll tell you like I have

Time: 10557.479

patience and if they're at the end of

Time: 10560.12

their rope and we are having a lot of

Time: 10562.34

trouble controlling their vision loss

Time: 10564.319

from glaucoma I'm already recommending

Time: 10566.96

in these limited cases uh hey why don't

Time: 10569.6

you try this it's almost certainly safe

Time: 10572.74

and it may and it may help and it may

Time: 10575.84

help protect your vision over time so so

Time: 10578.24

that's that's an area that's kind of

Time: 10580.04

another like kind of could be a yes

Time: 10582.38

early data's point in the right

Time: 10584.18

direction you want to be careful but uh

Time: 10587.84

but I but I am starting to recommend it

Time: 10590

at the same time that we're actually

Time: 10591.92

doing the clinical trials now that said

Time: 10594.92

there are a lot of other things that

Time: 10596.66

people talk about other supplements

Time: 10599.24

ginkgo biloba things with generic names

Time: 10602.84

on the internet like you know glaucoma

Time: 10604.939

preservation you know uh yeah that sort

Time: 10607.819

of thing makes my uh gives me hives you

Time: 10610.34

know yeah and these are areas where

Time: 10612.38

there might be scientific premise like a

Time: 10616.64

plausible explanation for how this

Time: 10618.5

should help but not good data that it

Time: 10621.62

actually helps thankfully in most cases

Time: 10624.02

these things are safe uh but I just

Time: 10627.26

worry about patience

Time: 10628.819

hitching their wagon to something that's

Time: 10630.979

not going to help them getting their

Time: 10632.42

hopes up uh worst case scenario not

Time: 10635.84

taking their actually proven prescribed

Time: 10638.3

treatments and instead using an

Time: 10640.399

alternative therapy that doesn't have

Time: 10642.02

data to support it and so I think there

Time: 10644.72

there's a lot of you know

Time: 10647.18

um uh you know either unfounded

Time: 10650.62

unsupported uh you know information it

Time: 10654.08

travels around chat rooms travels around

Time: 10656.3

the internet one person tells the next

Time: 10658.34

person you know there's inappropriate

Time: 10660.319

advertising for some of these uh and

Time: 10663.439

they're you know I really don't want

Time: 10665.359

patients to be hurt not necessarily hurt

Time: 10668.12

by taking something that's not helping

Time: 10669.979

but but maybe hurt by feeling like I

Time: 10672.2

don't have to go to the doctor I'm

Time: 10673.52

taking this supplement and that would be

Time: 10675.2

obviously a really bad potential outcome

Time: 10677.84

for a patient yeah I completely agree

Time: 10679.939

supplements are just as the name

Time: 10682.1

suggests a supplement to an already

Time: 10686.02

hopefully healthy lifestyle and use of

Time: 10689.54

medication where it's prescribed and

Time: 10691.24

I've often said on the podcast that

Time: 10693.68

sometimes the best dose of a supplement

Time: 10695.96

is zero milligrams so I do appreciate

Time: 10699.439

you touching on those themes because

Time: 10701.72

um supplementation is something that

Time: 10702.979

comes up from time to time on the

Time: 10704.42

podcast and I know that I've certainly

Time: 10706.7

have seen a number of these different I

Time: 10708.92

Envision support supplements we aren't

Time: 10710.84

affiliated with any of them I don't

Time: 10713.66

personally take any of them but these

Time: 10716.359

clinical trials sound promising so I'm

Time: 10718.46

going to keep an ear to the ground for

Time: 10721.819

them

Time: 10723.14

as a final question and hopefully a

Time: 10726.2

topic that we can cover in more detail

Time: 10727.7

in a subsequent episode of the podcast

Time: 10730.1

because I absolutely want to have you

Time: 10731.66

back to discuss this in more detail

Time: 10733.76

I'd like to just get your thoughts on

Time: 10735.319

the fact that the neural retina is in

Time: 10737.779

fact neural and it's part of the brain

Time: 10739.34

and we are hearing an increasing amount

Time: 10742.1

of positive chatter about the use of

Time: 10745.46

Imaging the eye and the retina directly

Time: 10748.16

as a way to detect other forms of

Time: 10750.08

neurodegeneration for those that are

Time: 10752.66

listening or for watching

Time: 10754.88

um you know I'm putting my hands up in

Time: 10756.68

kind of C shape at the back of your eye

Time: 10758.899

is lined with these with this three cell

Time: 10761.24

layer thick thing that is the neural

Time: 10762.979

retina which are really pieces of brain

Time: 10764.6

that connect to the rest of the brain

Time: 10766.22

and because it resides in the eyes and

Time: 10769.64

outside the cranial Vault people like

Time: 10772.04

you

Time: 10772.939

skilled clinicians with the appropriate

Time: 10774.8

tools can look into the eye and see the

Time: 10777.92

brain directly without having to cut

Time: 10779.18

through the skull

Time: 10780.26

and my understanding is that more and

Time: 10782.84

more ophthalmologists are seeing

Time: 10785.899

cases where degeneration of the retina

Time: 10788.66

is correlated with degeneration of

Time: 10792.26

structures deeper in the brain making

Time: 10794.12

Imaging of the neural retina perhaps one

Time: 10796.46

of the best diagnostic tools for

Time: 10798.56

predicting and tracking the progression

Time: 10800.3

of Alzheimer's and other forms of

Time: 10801.979

neurodegeneration do I have that right

Time: 10803.66

yeah absolutely actually this is a super

Time: 10805.88

exciting area you know we we have this

Time: 10807.979

long-standing sang in Ophthalmology that

Time: 10809.779

the eye is a window to the brain the

Time: 10811.279

eyes of window to the soul of course is

Time: 10813.2

a log standing sang right and and it

Time: 10815.899

turns out that you know in Alzheimer's

Time: 10818.96

disease as an example you know we really

Time: 10821.779

talk a lot about the degeneration of

Time: 10824.12

basal forebrain cholinergic neurons that

Time: 10826.64

are leading to the cognitive deficits in

Time: 10829.22

Alzheimer's disease but it turns out

Time: 10831.56

that there is also some degeneration

Time: 10833.479

throughout other areas of the brain

Time: 10835.04

including the retina and since we have

Time: 10837.319

such a relatively easy time Imaging the

Time: 10840.2

retina you can go into your doctor's

Time: 10842.18

office and get a quick little sort of

Time: 10844.46

laser scan of the retina a picture of

Time: 10846.979

the ratna compared to like going through

Time: 10848.96

a full MRI processor for your brain

Time: 10851.8

and we can detect the degeneration of

Time: 10855.56

the retina and optic nerve associated

Time: 10857.06

with Alzheimer's disease it looks like

Time: 10859.16

the same thing is happening in

Time: 10860.42

Parkinson's disease in Ms now one of the

Time: 10863.6

issues is that in a lot of these

Time: 10866.06

degenerative diseases were able to

Time: 10868.58

detect the difference in the retina but

Time: 10870.38

were not necessarily able to say hey if

Time: 10873.439

we see this in the retina it's multiple

Time: 10875.42

sclerosis but if we see that in the

Time: 10877.76

retina it's Alzheimer's disease so there

Time: 10880.46

may not be there may be good sensitivity

Time: 10882.56

to detecting the disease and to

Time: 10884.899

following whether your diseases your

Time: 10886.76

brain disease is getting worse but there

Time: 10889.1

may not be very good specificity

Time: 10891.04

differentiating the different diseases

Time: 10893

and I say that with a very big asterisk

Time: 10896

at the end of that sentence because

Time: 10897.68

there's actually amazingly cool new data

Time: 10901.279

one of our colleagues who you know Alf

Time: 10903.8

dubra

Time: 10905.18

has helped revolutionize a new way of

Time: 10907.939

Imaging the retina that's giving us now

Time: 10909.76

cellular resolution and even subcellular

Time: 10913.64

resolution seeing things smaller than

Time: 10916.46

the sizes of cells inside our retina and

Time: 10919.46

recently in one of his projects he's

Time: 10921.26

teamed up with another one of our

Time: 10922.52

faculty Heather Moss she's a

Time: 10925.1

neuro-ophthalmologist so she really

Time: 10926.899

specializes clinically in the eye brain

Time: 10929.84

connection and her research focuses on

Time: 10931.939

that and together they made actually an

Time: 10934.46

amazing recent discovery of very

Time: 10937.359

specialized unusual novel structures

Time: 10940.34

that they can detect in the retina of

Time: 10943.7

patients with multiple sclerosis and

Time: 10946.34

whether these kinds of discoveries or

Time: 10948.26

other similar kinds of discoveries are

Time: 10950

going to lead to kind of a a whole new

Time: 10952.22

generation of biomarkers which are ways

Time: 10955.34

of measuring disease diagnosing who has

Time: 10957.859

the disease figuring out who's getting

Time: 10959.479

worse from the disease figuring out

Time: 10961.58

who's responding to therapies that we're

Time: 10963.56

trying to use to treat the diseases this

Time: 10965.84

is a very exciting area and this really

Time: 10968.359

touches on what we're all hoping is the

Time: 10970.88

future of of eye care as well as the

Time: 10972.979

rest of medicine and that's that's

Time: 10974.3

Precision medicine but also what we call

Time: 10976.279

Precision Health we really want to not

Time: 10978.56

just figure out what drug treatment to

Time: 10980.6

give this patient versus that treatment

Time: 10981.979

but we really want to figure out who's

Time: 10984.08

at risk of even getting some of these

Time: 10986.12

diseases and gosh we could intervene now

Time: 10988.46

and prevent them from ever getting in

Time: 10990.5

trouble in the future

Time: 10992

fantastic can't wait to hear more about

Time: 10994.399

those developments and listen I want to

Time: 10997.52

say on behalf of the listeners and

Time: 10999.92

myself just thank you ever so much for

Time: 11002.62

the discussion today I don't think I can

Time: 11004.42

ever recall a conversation that's

Time: 11006.399

included so much basic science and

Time: 11008.319

clinical science and also so many

Time: 11010.18

actionable recommendations both do's and

Time: 11012.88

don'ts as it relates to something so

Time: 11015.399

critical as Eye Health I also I was just

Time: 11018.34

reflecting for a moment

Time: 11019.899

about the fact that I think you and I

Time: 11021.52

met 20 years ago when you were a

Time: 11023.2

graduate student by the way folks

Time: 11025

um Jeff is uh sort of the Kobe Bryant of

Time: 11027.64

sorts although unfortunately still with

Time: 11029.68

us in the sense that he went directly

Time: 11031.479

from his MD and phds skipped his postdoc

Time: 11035.02

didn't require one directly to being a

Time: 11036.64

faculty member most people don't do that

Time: 11039.04

they do a five-year postdoc in between

Time: 11040.54

wait and then I believe he's going to

Time: 11043.12

tell me all the places I'm wrong and I

Time: 11044.319

should just come clean that

Time: 11045.88

um Jeff is my chair of department at um

Time: 11048.939

Stanford School of Medicine Department

Time: 11050.38

of Ophthalmology so for me I I see this

Time: 11053.319

as a particularly warming but also

Time: 11056.439

um at once unpredictable but pure

Time: 11059.38

pleasure of an experience to get to

Time: 11061.3

learn so much from you because I don't

Time: 11062.439

think we've had this long to sit down

Time: 11063.7

and talk science in a very long time so

Time: 11066.359

thank you for doing that for my own sake

Time: 11070

thank you for teaching us so much about

Time: 11071.74

how to take care of our Eye Health and

Time: 11073.359

now you can tell me where my history is

Time: 11075.34

wrong maybe my hippocampus is

Time: 11076.72

degenerating no it's been a pleasure

Time: 11078.819

over the years I have nothing but the

Time: 11080.439

warmest memories of of you as a postdoc

Time: 11083.14

and me as a graduate student getting to

Time: 11084.76

be you know nerds in the laboratory uh

Time: 11087.52

20 years ago 20 years ago at Stanford in

Time: 11091

the lab of Ben Barris and uh and very

Time: 11093.819

warm wonderful feelings about you know

Time: 11096.22

learning science and how to do science

Time: 11098.02

and making real advances even at that

Time: 11100.3

time and then the fact that we've had

Time: 11101.979

the chance to cross paths in San Diego

Time: 11104.56

again at Stanford collaborate on

Time: 11107.2

important projects having to do with you

Time: 11109.66

know developing new ways of measuring

Time: 11111.16

diseases developing new ways of treating

Time: 11112.899

diseases the idea that we're going to

Time: 11115.24

actually bring forward some of the

Time: 11116.979

advances that our lab that you're a lab

Time: 11120.04

that other people's Labs have been

Time: 11121.779

making in neuroprotection in diseases

Time: 11124.84

like glaucoma and macular degeneration

Time: 11126.52

in regeneration of the optic nerve of

Time: 11129.46

the retina we're real close on a lot of

Time: 11132.819

those this is a major topic of really

Time: 11135.16

The Cutting Edge research that we're

Time: 11136.72

really trying to keep pushing forward

Time: 11138.46

because we know it's so important to

Time: 11140.14

patients you know I I often joke you

Time: 11142.779

know my mother had a uh a sign outside

Time: 11146.5

the bathroom and it said remember how

Time: 11149.68

long a minute is depends on what side of

Time: 11151.779

the door you're on and I I really

Time: 11154.42

appreciate that like as fast as we're

Time: 11156.279

trying to go with our research and

Time: 11157.899

moving that into clinical research which

Time: 11159.7

I think we're doing very effectively in

Time: 11161.56

the department really working on Vision

Time: 11163.779

restoration research in the department I

Time: 11166.479

appreciate that as fast as we think

Time: 11167.8

we're going it's not fast enough for so

Time: 11169.96

many patients who are suffering from

Time: 11171.279

these diseases so thanks very much for

Time: 11173.439

having me on it's been a real pleasure

Time: 11175.14

reconnecting over these many important

Time: 11177.46

topics I really appreciate the chance to

Time: 11179.8

talk with you well delighted to do it

Time: 11181.66

and looking forward to doing it again

Time: 11183.58

you're an amazing colleague friend

Time: 11185.74

clinician and now public health educator

Time: 11188.74

thank you

Time: 11190.06

thank you for joining me for today's

Time: 11191.56

discussion all about I Envision Health

Time: 11193.779

with Dr Jeffrey Goldberg I hope you

Time: 11196.06

enjoyed the discussion as much as I did

Time: 11198.04

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Time: 11200.26

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for your interest in science

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[Music]

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