AMA #3: Adaptogens, Fasting & Fertility, Bluetooth/EMF Risks, Cognitive Load Limits & More

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ANDREW HUBERMAN: Welcome to the Huberman Lab podcast,

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where we discuss science and science-based tools

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for everyday life.

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[MUSIC PLAYING]

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I'm Andrew Huberman, and I'm a professor

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of neurobiology and ophthalmology

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at Stanford School of Medicine.

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Today is an ask-me-anything or AMA

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Without further ado, let's get to answering your questions.

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And as always, I will strive to be as accurate as possible,

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as thorough as possible, and yet as concise as possible.

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The first question today is about adaptogens.

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Some of you may have heard of adaptogens.

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I'm guessing many of you have not heard of adaptogens.

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The strict definition of adaptogens is still evolving.

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Meaning, no one really knows what adaptogens mean

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and what's included in adaptogens

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and what's excluded from adaptogens.

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But the most common definition of an adaptogen

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is a compound that is typically a supplement or a drug.

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Although, it could be a behavior, if you really

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think about it, that helps you adapt to and buffer stress.

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So when you hear about adaptogens,

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there are three main categories of adaptogens

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that come to mind.

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The first are things that are contained in food.

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So these would be vitamins or micronutrients

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that one could easily find in food.

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But one would have to consume a fairly restricted number

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or type of foods in order to obtain those things,

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or consume a lot of those foods in order

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to get sufficient dosages of those adaptogen compounds

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in order to buffer stress.

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Some good examples of these would

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be any kind of vitamin, either water-soluble or fat-soluble,

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that can adjust or reduce what are so-called reactive oxygen

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species.

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And then that's what gives rise to this idea

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that antioxidants are good for us.

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Now, over the last 10 years or so, there's been a shift.

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What shift has occurred?

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Well, about 10 years ago, you often heard

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about antioxidants, antioxidants, antioxidants

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and vitamins, antioxidants in this food,

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this superfood, et cetera.

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And why were people talking about antioxidants?

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Well, just to remind you, reactive oxygen species

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are types of reactions and molecules

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that occur in cells when cells get stressed and/or age.

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And antioxidants are the compounds

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that reduce those reactive oxygen species.

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Reactive oxygen species are bad for cells

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because they tend to hinder the function of mitochondria,

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which are associated with energy production in those cells.

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So what do we know for sure?

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We know that as cells get older, or as any cell

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or biological system organ tissue,

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et cetera, get stressed a lot over time,

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the number of reactive oxygen species

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increases in those cells and tissues and organs.

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And antioxidants, which can include certain vitamins

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but also some micronutrients, are

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effective in reducing those reactive oxygen species.

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Now, what's occurred over the last 10 years

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is that we know that reactive oxygen species are

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a major source of depleting cellular function by way

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of depleting mitochondrial function.

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But they are just one of many mechanisms

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that can deplete cellular function

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mitochondrial function.

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So nowadays, you'll hear about reactive oxygen species

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and antioxidants, but not as much as you used to.

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Now, you hear a lot more about inflammatory responses

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and inflammatory cytokines also being an issue.

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And the truth is all of these things are an issue.

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So going back to this question about adaptogens,

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adaptogens include these three categories.

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I've told you the first, which are the vitamins

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and micronutrients that are contained in food that

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can reduce reactive oxygen species

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and other aspects of cell or stress,

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such as inflammatory cytokines.

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What are some of those things that occur in foods?

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Well, in order to answer that, let's

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just think about what sorts of foods, themselves,

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can act as adaptogens.

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It's commonly held that the dark, leafy greens type foods,

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for those of you that eat plants.

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And I think the majority of people out there do eat plants.

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I know that the carnivore diet and lion

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diet and some other diets tend to exclude plants,

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and we'll address that briefly at some point

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in today's discussion.

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But dark, leafy greens are known to contain

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a number of compounds in the form of vitamins

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and micronutrients that are very effective in reducing

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reactive oxygen species and inflammatory cytokines.

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So if you're somebody who's interested

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in adaptogens and adaptogenic processes, reducing

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stress and buffering stress, which, of course, has

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its role in buffering daily stress in order

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to help you sleep better to improve

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cellular function for longevity sports performance,

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cognitive performance, that is all good

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and it makes sense why people would

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be interested in adaptogens.

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But remember that the two main adaptogens

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that you should think to first are going

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to be behaviors and nutrition.

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I started with nutrition on purpose.

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As I mentioned, we'll get to behaviors in a moment.

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So if you're interested in adaptogens at all,

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I highly recommend that you include at least two

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to four servings of dark, leafy greens

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and/or cruciferous vegetables per day.

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I think that would be highly advantageous.

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And just be aware that excessively heating dark,

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leafy greens or cruciferous vegetables

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can actually destroy the very nutrients

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and micronutrients that act in an adaptogenic way.

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That does not mean that you need to eat raw broccoli

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or cauliflower, just the thought of that makes me nauseous,

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it's very hard to digest.

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Some people might like that or can digest it more easily

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than others.

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So it's perfectly fine to cook your cruciferous

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vegetables and dark leafy greens,

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but you don't want to overcook them.

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What's overcooking and what's undercooking?

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There's no strict cutoff in terms of temperature.

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But basically, what the literature

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says is that if you heat vegetables to the point

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where the colored fluid is leaching out

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of them into a broth type, into water

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or whatever fluid surrounds them, well, then you

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would be well off to ingest that fluid as well because it

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contained in the water or the fluid that's leaching out

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from the cruciferous vegetables or from the dark leafy greens,

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are going to be a lot of those very adaptogenic molecules

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that you're interested in the first place.

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OK.

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So I probably surprised some people

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by starting off my answer to the question of "What

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are adaptogens?

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Are they worth thinking about in pursuing?

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And if so, how can I get them?" by talking about food.

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But I think it is important to understand that you can get

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a lot of adaptogens from food.

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And indeed, some of the best adaptogens

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do come from dark leafy greens and cruciferous vegetables.

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So I'd be remiss if I didn't mention that.

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The other two categories of adaptogens

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are going to be supplement-based adaptogens and then

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behavioral adaptogens.

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Again, here adaptogen defined as anything

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that can buffer stress in a substantial or meaningful way

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in order to support cellular health, organ

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health, and overall daily living and functioning,

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including sleep and performance in mental health.

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So the second category of adaptogens

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are going to be supplements.

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And here, again, I just want to take a step back,

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make sure that we are clear about

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our operational definition about what a supplement is.

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We had an episode all about how to design a rational guide

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to supplementation, which included,

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for example, the idea that for some people,

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the optimal dosage of many supplements

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is going to be zero.

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And for other people, the dosage will be something else.

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But to really pinpoint the key message from that episode

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that I'd like to reiterate now, but a key message

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from that episode that I'd like to reiterate now

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is that many people think of supplements

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as just vitamin supplements.

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And for that reason, you'll often

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hear the argument, "Oh, well, aren't supplements just

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expensive urine.

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Couldn't you get all of that from food?"

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Aren't you just urinating out all the water-soluble vitamins

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and maybe even storing excess amounts

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of the fat-soluble vitamins in a way that's unhealthy

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or not cost-effective?"

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And so on.

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When we talk about supplements, yes, it

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can include vitamin supplements.

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However, there are many compounds

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that we would describe as supplements that are not

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vitamin supplements, and that you could not obtain from food

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or that you could never obtain from food

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in sufficient enough qualities to have

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a robust positive biological effect without consuming

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an enormous number of calories or overriding your gut

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mechanically.

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For instance, if there were, say, a herb, and we'll

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talk about such herbs in a moment,

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that contained an effective adaptogen,

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but you would never want to eat the plant

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itself or include that herb in any kind of recipe,

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well then, chances are this herb, which

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we'll define in a moment, is not a vitamin supplement.

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It is probably not even best thought of as a supplement,

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it's best thought of as a compound

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that sold over the counter, much like a prescription drug.

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Although, it's not prescription.

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It doesn't require a prescription to get it.

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So there are a lot of things like that we

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include under the umbrella of this word supplements.

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And unfortunately, because of that, a lot of people

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think, "Oh, you don't need supplements."

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And, of course, you don't need supplements per se,

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but many people do derive tremendous benefit from them.

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In the context of adaptogens, there

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are two or three in particular that

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can be very beneficial for buffering the stress

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response, especially, over short periods of time

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of about two to three weeks.

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So when would you use these?

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Well, for instance, if you are in a particularly stressful

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mode of life, either because of family or relational or school

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or work demands or new kid in the house

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or-- any number of different things, or you've been ill

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or you're recovering from injury,

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taking an adaptogen in the form of a supplement

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can actually be very useful for buffering this hormone

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and the general system is associated with,

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called cortisol.

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It's very healthy to have high levels

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of cortisol early in the day, shortly after you wake up.

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And then that ought to taper off toward the afternoon

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and evening.

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However, if cortisol is chronically

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elevated throughout the day, or if that peak in cortisol

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is arriving too late in the day, that

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is known to be associated with mental health

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and physical health issues.

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Has been shown by labs at Stanford and elsewhere.

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It's been shown in animal models and in humans.

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Talked many times before, and I'll just remind you again.

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One of the best ways to restrict that cortisol peak

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to the early part of the day is to get morning sunlight

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in your eyes as soon as you can.

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Once the sun is up, get outside face

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in the direction of the sun, even on overcast days.

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Don't wear sunglasses, look at it for five to 30 minutes.

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Definitely blink so you don't damage your eyes,

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so on and so forth.

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Why five minutes or 30 minutes?

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Well, five minutes on a clear day should be sufficient,

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longer would be fine.

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Again, blink so that you protect your eyes.

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Blink as needed.

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Face in the general direction of the sun.

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On days when you have a lot of overcast or it's really dark,

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dense cloud cover, well, then, you'd

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want to be outside longer.

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And if you don't have access to sunlight for whatever reason,

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then you want to do the same thing

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with bright artificial lights indoors, either so-called SAD

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lamp or otherwise.

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That's a great way to restrict that cortisol peak

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to early in the day.

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But even if you're doing that, if you

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have a stressful life for whatever reason,

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even if you're getting that morning sunlight, which I hope

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you are, you're getting your exercise,

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you're trying to sleep better and more as we all

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should most of the time, well, then you

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may be somebody who wants to take a adaptogen

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in the form of a supplement.

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And the three supplements that can

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be very effective in buffering cortisol

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are ashwagandha, which I'll talk about first, lion's mane

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and chaga.

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Lion's mane and chaga are in the fungi group,

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so they count as mushrooms.

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They are not psychedelic mushrooms.

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Let's talk about ashwagandha first.

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Ashwagandha is at the top of the list

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because it is indeed a very potent adaptogen.

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How can I say that?

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Well, there are a number of studies

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now, including several excellent ones

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in humans, that report that taking

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two doses of 300 milligrams of ashwagandha per day

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can, very dramatically, buffer cortisol.

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So this is something that you would

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have a near-impossible time accessing from food.

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I can't imagine that, unless you're

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cooking with the very sources of ashwagandha

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and extracting exact amounts that you'd

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be able to get this in any other form except supplement form.

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So here I'm going to just briefly reference a paper

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and we can provide a reference link to this, that is.

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This is a paper from 2012 that's had

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a lot of excellent follow-up papers that support it.

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The title of the paper is A prospective randomized

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double-blind placebo-controlled study of safety and efficacy

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of high concentration of full spectrum

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extract of ashwagandha root in reducing

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stress and anxiety in adults.

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And it's a really nice study.

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Not a huge subject pool, but both men and women, and

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has carried out for long enough that they

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got to see some really interesting results.

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And I think the most interesting result

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is that taking 300 milligrams of ashwagandha twice a day

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led to enormous--

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I mean, just enormous changes in serum cortisol.

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The statistical significance that they observed in the study

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was really fantastic, fantastically high

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statistical significance.

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They saw the effects of ashwagandha on day 15,

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having initiated the ashwagandha consumption on day one,

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of course, day 30 and day 45.

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And again, this was dramatic reductions

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in stress as perceived by people.

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So subjective stress and cortisol levels.

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So ashwagandha is very potent at reducing cortisol.

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How would you recapitulate this if you

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wanted to use ashwagandha to buffer stress?

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Well, a couple of key points.

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I mentioned earlier that you want your cortisol peak

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to come earlier in the day.

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Therefore, you would not want to buffer

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cortisol early in the day.

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In fact, cortisol peaking early in the day

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provides an anti-inflammatory immune-supporting, focus

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and mood supporting effect all day long.

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So I would recommend that people take

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their first dose of ashwagandha anywhere from 250 to 300

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milligrams.

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Sometime in the early afternoon and again in the evening,

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as opposed to taking a morning dose in an afternoon dose.

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Also, if you're somebody who's exercising

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for sake of trying to induce adaptations like hypertrophy,

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the growth of muscles or strength,

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or improve your endurance in any way,

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muscular endurance or more traditional cardiovascular

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endurance, then I recommend that you not take your ashwagandha

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prior to exercise because part of the adaptation response

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is triggered by increases in cortisol during exercise.

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Sort of in the same way that some of the best

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adaptations to exercise are reductions in blood pressure

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and resting heart rate.

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And those are stimulated by increases in blood pressure

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and increases in heart rate during exercise.

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That's just how these biological systems work.

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So the takeaway is pretty simple.

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If you're interested in using ashwagandha as an adaptogen,

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I would restrict it to later in the day

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if you can and not before exercise.

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Divide it into two doses of 250 to 300 milligrams.

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That's what this paper and other papers

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like it seem to indicate.

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And then a very important final point about ashwagandha,

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which is that if you're going to take ashwagandha,

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I recommend not taking it for longer than a month-and-a-half

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as they did in this study.

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In fact, I would suggest that you only

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take ashwagandha around periods of moderate to extreme stress.

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What's moderate, what's extreme is

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going to depend on what you're going through.

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Only how much stress and life events you can tolerate.

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So if you've had trouble sleeping and that's

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unusual for you.

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Or, you're dealing with a very difficult life circumstances

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or excessive work demand, or a new kid, as I mentioned before.

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Well, then buffering stress with ashwagandha,

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buffering cortisol in the afternoon and evening

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can be very beneficial for you.

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But then I would say after about 30 days maximum,

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I would take at least two to four weeks off.

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Two weeks is probably enough, but four weeks off

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because you don't want to chronically buffer cortisol.

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It's just not a good idea.

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But that said, I think ashwagandha

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is a very powerful adaptogen. I would

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place at the top of the list of supplement-based adaptogens.

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But keep in mind that even if you're

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taking a supplement-based adaptogen,

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that's no reason to abandon the nutrition and behavioral type

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adaptogenic effects that you can create through eating

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dark leafy greens, cruciferous vegetables,

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then we'll talk about the behaviors in a moment.

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The other two supplement-based adaptogens, as I mentioned,

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are lion's mane mushroom and chaga.

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And I get asked a lot about lion's mane and chaga for sake

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of their purported roles in acting as nootropics as quote

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unquote "smart drugs."

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There are fewer data on the beneficial roles

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of lion's mane and chaga for sake of nootropic effects--

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we'll do an entire episode on nootropics at some point.

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But there have been a few studies showing

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that lion's made in supplementation and chaga

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supplementation can improve memory,

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and maybe even divergent thinking

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associated with creativity and things of that sort.

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Again, these are not psychedelic mushrooms.

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That said, there are good data showing that 1,000 milligrams,

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that is 1 gram, of lion's mane per day and/or--

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I will talk about the end/or portion in a moment,

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and/or chaga mushroom at 500 to 1,500 milligrams per day

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can act as adaptogens in, again, reducing cortisol.

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But also and mainly reducing some of the anti-inflammatory

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cytokines that are known to circulate in high abundance

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when you're under a lot of psychological and/or physical

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stress.

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Things like interleukin 6 and some related molecules.

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So here's what I would recommend.

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If you are interested in exploring adaptogens,

Time: 1079.71

I'm a big fan, as some of you probably

Time: 1081.57

know, if you heard that episode on rational guide

Time: 1083.838

to supplementation.

Time: 1084.63

I'm a big fan of mainly focusing on taking supplements

Time: 1088.47

in single-ingredient formulations

Time: 1090.42

so that you can figure out what dosages are best for you,

Time: 1094.21

and so that you can toggle in and out those adaptogens as

Time: 1097.26

needed.

Time: 1097.9

So I, of course, am a fan of taking

Time: 1100.11

certain blends and mixes, the one that we talk

Time: 1102.03

about a lot on this podcast and we have been

Time: 1104.292

a sponsor from the beginning, I've taken for a decade

Time: 1106.5

now long before I ever had a podcast,

Time: 1108.6

is Athletic Greens, which some of you might note

Time: 1111.06

does contain some ashwagandha.

Time: 1112.59

Although, the levels of ashwagandha

Time: 1114.18

that are contained in Athletic Greens

Time: 1115.722

are low enough that I don't see any issue with taking Athletic

Time: 1119.01

Greens consistently, day to day, every day, because you're

Time: 1122.64

not getting anywhere near that 600-milligram dosage.

Time: 1125.46

But the idea is that if you were going

Time: 1127.35

to take any adaptogen for sake of buffering stress

Time: 1131.55

over the short term, say for a week or two weeks or a month,

Time: 1135.03

and then taking that recommended time off,

Time: 1137.22

I would start with ashwagandha.

Time: 1139.08

And then if you feel you need something else to buffer

Time: 1142.05

stress, keeping in mind, of course,

Time: 1143.552

that you're doing the behavioral and the nutritional things

Time: 1146.01

to buffer stress as well.

Time: 1146.91

You can never abandon those, right?

Time: 1148.44

Well, then I would suggest adding 1,000 milligrams

Time: 1151.02

or 1,000 milligrams of chaga per day

Time: 1153.84

and seeing how that further benefits your system in terms

Time: 1158.197

of buffering stress.

Time: 1159.03

How would you measure if your stress is being reduced?

Time: 1161.31

Well, you're going to be sleeping better at night.

Time: 1163.41

You're going to feel subjectively better, lower

Time: 1165.368

levels of anxiety.

Time: 1166.45

All the things that are measured in the types of studies

Time: 1168.783

I described before.

Time: 1170.11

Now, of course, there's nothing preventing you

Time: 1172.56

from taking 600 milligrams of ashwagandha,

Time: 1174.76

a gram of lion's mane, and a gram of chaga.

Time: 1176.82

I know some people like to just kind of go

Time: 1178.827

full tilt into everything.

Time: 1179.91

But I am a big believer in really trying to isolate which

Time: 1184.17

supplements and molecules work best for you and which ones

Time: 1186.96

don't.

Time: 1187.71

Do you need to cycle on and off lion's mane and chaga?

Time: 1191.25

I'm not aware of any data showing that you do.

Time: 1193.5

If, however, you're taking them every day,

Time: 1195.72

I recommend that you cycle off them after a period of 30 days

Time: 1199.41

or so.

Time: 1199.95

And I want to be very clear about this,

Time: 1201.63

just because I said cycle off after a period of 30 days

Time: 1203.94

or so does not mean that you can't take them

Time: 1206.31

for a shorter period of time.

Time: 1207.587

So for instance, if you know that you're coming up

Time: 1209.67

on a big week of stress, well, then you

Time: 1212.94

could take ashwagandha and/or lion's mane and/or chaga

Time: 1218.19

for that week or just that week or heading into that week

Time: 1220.8

or in the following week and then stop.

Time: 1222.06

There's no reason why you couldn't take them even just

Time: 1223.71

for one day.

Time: 1224.31

Although, the effects tend to be a bit cumulative, at least,

Time: 1227.46

when we're talking about buffering anxiety.

Time: 1230.587

In terms of buffering cortisol, that's

Time: 1232.17

a very potent effect that as far as we know,

Time: 1234.31

is going to take place on day one.

Time: 1235.74

Again, keep that cortisol buffering effect away

Time: 1238.86

from exercise.

Time: 1240.18

At least, don't take it before exercise.

Time: 1242.31

And try and buffer your cortisol in the afternoon and evening,

Time: 1245.498

and this is assuming that you're working a conventional shift

Time: 1248.04

and you're not up all night and sleeping

Time: 1249.78

all day for sake of shift work.

Time: 1252.27

So hopefully, that clarifies things

Time: 1253.92

about what adaptogens are.

Time: 1255.39

In fact, I never actually read the specific question,

Time: 1257.67

but I think I've touched on a number of issues

Time: 1260.888

that were related to the specific question.

Time: 1262.68

And then I'll answer the last portion of the answer

Time: 1264.805

to this question in a moment, as it

Time: 1266.52

relates to behavioral tools that can act as adaptogens.

Time: 1270.395

The question, itself, was there's

Time: 1271.77

a lot of mixed information out there about adaptogens

Time: 1274.302

like ashwagandha.

Time: 1275.01

And I think that relates to what I said earlier, which

Time: 1276.78

is that the definition of an adaptogen

Time: 1278.64

has not really been cemented in various communities.

Time: 1283.543

It's different in different communities,

Time: 1285.21

and it's generally used as a matter of convenience

Time: 1288.75

rather than really strictly defining what it is.

Time: 1290.92

And hopefully, we've defined it accurately and broadly enough

Time: 1295.32

today as something that buffers stress.

Time: 1298.092

The second part of the question was

Time: 1299.55

what does the scientific evidence say about adaptogens

Time: 1301.8

and their ability to mediate body stress response?

Time: 1304.21

They say quite a lot, and they say

Time: 1306.09

that the stress response can be buffered substantially

Time: 1309.39

by certain adaptogens.

Time: 1311.19

Mainly, dark leafy greens, cruciferous vegetables,

Time: 1315.54

ashwagandha, lion's mane, and chaga,

Time: 1317.7

and of course, all the behavioral things

Time: 1319.44

that are critical that I will list off in a moment.

Time: 1321.34

And then the third portion of the question

Time: 1322.83

is, is there any solid evidence that

Time: 1324.33

has an effect on neurotransmitters or the HPA,

Time: 1327.24

which is part of the stress modulation access?

Time: 1330.42

The best evidence is that adaptogens can reduce cortisol

Time: 1333.93

itself.

Time: 1335.19

There is very little evidence that adaptogens can directly

Time: 1338.85

modulate neurotransmitters or neuromodulators like dopamine,

Time: 1342.55

serotonin, et cetera.

Time: 1343.59

But by adjusting the timing and levels of cortisol,

Time: 1346.5

especially in the afternoon and evening,

Time: 1349.38

that is going to have indirect effects on levels

Time: 1352.86

of dopamine, norepinephrine, et cetera, and serotonin.

Time: 1356.16

But not direct effects.

Time: 1357.64

So the general contour that makes for an ideal diurnal

Time: 1361.233

schedule-- you heard of nocturnal, well,

Time: 1362.9

the opposite that is diurnal, being awake during the daytime

Time: 1365.27

and asleep at night.

Time: 1366.103

The ideal kind of landscape of neurotransmitters

Time: 1368.72

is higher levels of dopamine, norepinephrine, and epinephrine

Time: 1372.59

in the early part of the day and cortisol,

Time: 1374.45

so-called catecholamines, dopamine, norepinephrine,

Time: 1376.83

and epinephrine.

Time: 1377.75

And high levels of cortisol early in the day as

Time: 1381.11

directed by sunlight, exercise, caffeine, hydration, movement,

Time: 1385.01

all that stuff, being awake and busy and outside

Time: 1387.29

or indoors with bright lights and moving

Time: 1389.36

about in the early part of the day

Time: 1390.89

and into the early afternoon, that's the best possible way

Time: 1393.392

that we are aware of to try and get

Time: 1394.85

those catecholamines released at the highest

Time: 1396.65

levels in the early part of the day.

Time: 1398.15

And then the ideal contour of a 24-hour cycle

Time: 1400.898

will be in the later half of the day.

Time: 1402.44

The evening and nighttime, you have higher levels

Time: 1405.11

of things like serotonin the GABAergic system,

Time: 1407.87

all the things that are somewhat sedative in preparing you

Time: 1410.36

for sleep and lower levels of the catecholamines and cortisol

Time: 1414.65

as I described before.

Time: 1415.89

So to directly answer the question,

Time: 1417.47

"Is there any evidence that adaptogens can

Time: 1419.24

alter your neurotransmitters?"

Time: 1421.22

Yes, but only indirectly.

Time: 1423.44

And yet, that indirect control over neurotransmitters

Time: 1426.53

is substantial and is important.

Time: 1428.67

And if you do what I described, such as getting morning

Time: 1430.993

sunlight and ideally, you'd get a little bit of deliberate

Time: 1433.41

cold water exposure, by the way, to boost

Time: 1435.118

adrenaline and norepinephrine and dopamine,

Time: 1437.63

those catecholamines early in the day.

Time: 1439.46

So quick one-minute cold shower, even

Time: 1441.467

or a three-minute cold shower, or if you have access to an ice

Time: 1444.05

bath early in the day, plus some sunlight,

Time: 1446.037

doesn't matter which one you do first,

Time: 1447.62

doing that early in the day is really

Time: 1449.18

going to create that peak of cortisol, dopamine, epinephrine

Time: 1452.51

early in the day.

Time: 1454.1

I can't emphasize how beneficial all of that can be.

Time: 1457.22

And exercise, if you can, early end of the day.

Time: 1459.288

Some people can't exercise till later in the day.

Time: 1461.33

I'd rather see people exercise later in the day

Time: 1463.46

than not at all, provided it does not

Time: 1465.23

disrupt their nighttime sleep, which of course, sleep

Time: 1467.503

is the foundation of mental health, physical health,

Time: 1469.67

and performance.

Time: 1470.58

So yes, there is modulation of neurotransmitters,

Time: 1473.122

but most of those are downstream of the effects on cortisol

Time: 1475.58

that we've been talking about.

Time: 1476.83

So we've defined nutritional adaptogens,

Time: 1479.27

supplement-based adaptogens-- although, I don't really

Time: 1482.03

like the word supplements anymore

Time: 1483.405

unless we're talking about vitamin supplements

Time: 1485.322

for reasons we talked about earlier.

Time: 1486.87

And then there's the third category

Time: 1488.33

of adaptogens, which are the behavioral tools that you

Time: 1490.58

can use to buffer stress, which qualifies

Time: 1492.89

those as an adaptogen. I think it's really important that we

Time: 1495.86

always keep in mind that yes, there are supplements,

Time: 1498.18

yes, there are prescription drugs out there.

Time: 1499.65

In fact, there are prescription drugs

Time: 1501.38

that you can get from a doctor that will potently

Time: 1505.16

zero out your cortisol.

Time: 1506.9

But most doctors are very reluctant to prescribe

Time: 1509.33

those drugs because cortisol provides

Time: 1511.52

a very important and functional role early in the day.

Time: 1514.97

Behaviors are very effective at reducing cortisol.

Time: 1518.03

What are the most effective behaviors to reduce cortisol?

Time: 1520.49

Well, we talked about, one, to restrict cortisol

Time: 1524.27

the early part of the day, which is viewing morning sunlight.

Time: 1527.06

But how would you buffer cortisol in the late afternoon?

Time: 1529.9

It's going to be all the things associated

Time: 1531.65

with reducing stress.

Time: 1532.88

For instance, 10 minutes or even--

Time: 1536.57

my laboratory and other laboratories have shown

Time: 1538.61

is even five minutes a day of just what

Time: 1541.28

would be called mindfulness meditation, very simple.

Time: 1543.447

You don't need to overcomplicate this.

Time: 1545.03

You could use a great app like the Waking Up app

Time: 1547.13

or another app of the sort.

Time: 1548.66

Or, you can simply sit down, eyes

Time: 1550.363

closed, breathe through your nose,

Time: 1551.78

and just concentrate on your breathing.

Time: 1553.13

Every time your mind drifts to something else,

Time: 1554.81

bring it back to your breathing.

Time: 1556.16

That's shown to reduce stress.

Time: 1558.38

You could do a five-minute deliberate breath work

Time: 1560.82

practice.

Time: 1561.32

My laboratory has published some work related to that.

Time: 1565.16

The breath work practice could be any number of things.

Time: 1567.53

The two that I recommend the most

Time: 1569.18

would be double inhale, followed by a full exhale,

Time: 1571.925

and then repeat for a period of five minutes.

Time: 1573.8

Known to substantially reduce anxiety, stress,

Time: 1576.35

and the various physiological systems

Time: 1578.24

associated with arousal.

Time: 1579.5

You could also use box breathing,

Time: 1581.21

inhale, hold, exhale, hold for equal durations

Time: 1583.88

for a period of five minutes, will substantially

Time: 1586.01

reduce stress.

Time: 1586.94

I'm a big fan, as many of you know, of yoga nidra,

Time: 1589.46

which involves no movement.

Time: 1590.683

It involves just lying there, listening to a script.

Time: 1592.85

Lots of yoga or scripts available online.

Time: 1595.43

If you're not interested in the intentions and other things,

Time: 1598.35

including yoga nidra, you can buffer stress

Time: 1600.71

using an adaptogen like NSDR, non-sleep deep breast.

Time: 1604.07

If you're interested in trying these sorts of things.

Time: 1606.77

There's a NSDR protocol that's 10 minutes long.

Time: 1610.56

Just put my name, Huberman, and NSDR

Time: 1613.79

into the search browser on YouTube.

Time: 1615.56

And Virtusan is provided in NSDR that's completely zero cost

Time: 1620.06

and works very well for reducing stress.

Time: 1622.16

It will also help teach your system

Time: 1624.08

and teach you how to learn to fall asleep better at night.

Time: 1627.08

So any of those practices, five to 10-minute breathing practice

Time: 1630.5

or meditation, or a NSDR yoga nidra.

Time: 1634.94

If you can do longer 20 or 30 minutes in the afternoon,

Time: 1637.28

that's known to buffer cortisol substantially as well.

Time: 1641.25

Any time you're encountering stress in real time,

Time: 1643.52

I highly recommend a tool over and over

Time: 1645.857

because it's so effective.

Time: 1646.94

The fastest way we to buffer stress and calm down

Time: 1649.46

is the so-called physiological sigh,

Time: 1651.35

big Inhale through the nose till your lungs are empty, but then

Time: 1654.71

sneak in a little bit more air by second inhale,

Time: 1658.16

maximally inflate the lungs, then

Time: 1659.54

a long exhale until you're lungs are empty.

Time: 1661.62

One to three of those will reduce your stress

Time: 1664.11

substantially.

Time: 1665.16

Over time that should reduce, that is, buffer

Time: 1667.89

your cortisol acting as an adaptogen.

Time: 1669.597

There are a lot of things.

Time: 1670.68

You can take a hot bath, you could take a hot shower,

Time: 1672.36

you can listen to some pleasant music.

Time: 1673.95

Anything that reduces your stress, technically,

Time: 1676.47

is an adaptogen. So I hope I've thoroughly answered

Time: 1679.62

your question by yours--

Time: 1680.753

I mean, of course, this answer is going out to all of you.

Time: 1683.17

This is a question that was asked by Justine Bevilacqua.

Time: 1686.07

I hope I pronounced that correctly, Justine.

Time: 1687.987

And thank you for that question.

Time: 1689.32

I think there are a lot of people

Time: 1690.06

interested in adaptogens.

Time: 1691.32

So now, you can use nutrition such as cruciferous vegetables,

Time: 1695.13

dark leafy greens.

Time: 1696.6

And I should also mention, if you're not

Time: 1698.43

ingesting enough calories each day, well,

Time: 1701.64

then you are going to be in a mild mode of stress.

Time: 1704.79

That's not to say that some people shouldn't take in fewer

Time: 1707.82

calories than they burn in order to lose weight,

Time: 1709.82

some people really need to do that for their health

Time: 1711.945

or for whatever other reason.

Time: 1713.227

But if you restrict calories too much,

Time: 1714.81

you are going to increase cortisol output.

Time: 1717.49

So keep that in mind.

Time: 1718.81

So ingest sufficient calories for you and for your goals.

Time: 1723.1

Aim to get dark leafy greens and cruciferous vegetables,

Time: 1726.09

don't overcook them.

Time: 1727.77

If you want to explore supplements,

Time: 1729.39

the best supplements to act as adaptogens

Time: 1731.49

are going to be ashwagandha, lion's mane, and chaga.

Time: 1734.7

One or two or three of those-- although, if you're

Time: 1738.42

going to pick one, I'd recommend ashwagandha, 600 milligrams

Time: 1741.42

per day, taken in the later-half of the day.

Time: 1743.29

And then there are the behavioral tools

Time: 1744.99

that we just talked about now, which are anything that reduces

Time: 1747.84

stress can reduce cortisol.

Time: 1750.45

And in doing so, are technically adaptogens.

Time: 1753.39

If you want to know more behavioral tools

Time: 1755.19

and other tools for adjusting stress

Time: 1756.81

and learn more about adaptogens, we

Time: 1758.28

did a whole episode called Mastering Stress.

Time: 1760.8

So you can look to that-- that episode also

Time: 1762.96

pretty clearly defines, I like to think, what short-term,

Time: 1766.39

medium-term, and long-term stress really are.

Time: 1768.348

Keep in mind, stress is part of life.

Time: 1769.89

Learning how to work with it, how to dance with it,

Time: 1772.015

how to buffer it is terrific.

Time: 1773.49

But zeroing out cortisol is not the goal.

Time: 1776.26

The goal is to learn to modulate and control your cortisol,

Time: 1779.97

and that's really what adaptogens are all about.

Time: 1782.31

Thank you for joining for the beginning

Time: 1784.05

of this ask-me-anything episode.

Time: 1785.85

To hear the full episode and to hear future episodes of these

Time: 1789.72

ask-me-anything sessions, plus to receive transcripts of them

Time: 1793.23

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Time: 1796.41

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Time: 1799.38

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Time: 1802.325

Just to remind you why we launched the Huberman Lab

Time: 1804.45

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Time: 1806.95

First of all, it's to raise support

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We are not going to change the format or anything

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And we are going to, specifically, fund research

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So this is a terrific way that they're

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Again, that's hubermanlab.com/premium.

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And as always, thank you for your interest in science.

Time: 1916.08

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