AMA #3: Adaptogens, Fasting & Fertility, Bluetooth/EMF Risks, Cognitive Load Limits & More
ANDREW HUBERMAN: Welcome to the Huberman Lab podcast,
where we discuss science and science-based tools
for everyday life.
[MUSIC PLAYING]
I'm Andrew Huberman, and I'm a professor
of neurobiology and ophthalmology
at Stanford School of Medicine.
Today is an ask-me-anything or AMA
episode, which is part of our premium subscriber content.
Our premium channel was launched in order
to raise support for the standard Huberman Lab podcast
channel, which still comes out once a week every Monday.
And of course, is zero cost to consumer.
The premium channel is also designed
to support exciting research being
done at major universities like Stanford and elsewhere,
research that's done on humans that should lead to protocols
for mental health, physical health,
and performance in the near future.
If you'd like to check out the premium channel subscription
model, you can go to hubermanlab.com/premium
and there you can subscribe for $10 a month or $100 a year.
We also have a lifetime subscriber option.
For those of you that are already Huberman Lab podcast
premium subscribers and you're watching and/or hearing this,
please go to hubermanlab.com/premium
and download the premium podcast feed.
And for those of you that are not already
Huberman Lab premium podcast subscribers,
you will be able to hear the first 15 minutes or so
of this episode.
And hopefully, that will allow you to discern whether or not
you would like to become a premium subscriber.
Without further ado, let's get to answering your questions.
And as always, I will strive to be as accurate as possible,
as thorough as possible, and yet as concise as possible.
The first question today is about adaptogens.
Some of you may have heard of adaptogens.
I'm guessing many of you have not heard of adaptogens.
The strict definition of adaptogens is still evolving.
Meaning, no one really knows what adaptogens mean
and what's included in adaptogens
and what's excluded from adaptogens.
But the most common definition of an adaptogen
is a compound that is typically a supplement or a drug.
Although, it could be a behavior, if you really
think about it, that helps you adapt to and buffer stress.
So when you hear about adaptogens,
there are three main categories of adaptogens
that come to mind.
The first are things that are contained in food.
So these would be vitamins or micronutrients
that one could easily find in food.
But one would have to consume a fairly restricted number
or type of foods in order to obtain those things,
or consume a lot of those foods in order
to get sufficient dosages of those adaptogen compounds
in order to buffer stress.
Some good examples of these would
be any kind of vitamin, either water-soluble or fat-soluble,
that can adjust or reduce what are so-called reactive oxygen
species.
And then that's what gives rise to this idea
that antioxidants are good for us.
Now, over the last 10 years or so, there's been a shift.
What shift has occurred?
Well, about 10 years ago, you often heard
about antioxidants, antioxidants, antioxidants
and vitamins, antioxidants in this food,
this superfood, et cetera.
And why were people talking about antioxidants?
Well, just to remind you, reactive oxygen species
are types of reactions and molecules
that occur in cells when cells get stressed and/or age.
And antioxidants are the compounds
that reduce those reactive oxygen species.
Reactive oxygen species are bad for cells
because they tend to hinder the function of mitochondria,
which are associated with energy production in those cells.
So what do we know for sure?
We know that as cells get older, or as any cell
or biological system organ tissue,
et cetera, get stressed a lot over time,
the number of reactive oxygen species
increases in those cells and tissues and organs.
And antioxidants, which can include certain vitamins
but also some micronutrients, are
effective in reducing those reactive oxygen species.
Now, what's occurred over the last 10 years
is that we know that reactive oxygen species are
a major source of depleting cellular function by way
of depleting mitochondrial function.
But they are just one of many mechanisms
that can deplete cellular function
mitochondrial function.
So nowadays, you'll hear about reactive oxygen species
and antioxidants, but not as much as you used to.
Now, you hear a lot more about inflammatory responses
and inflammatory cytokines also being an issue.
And the truth is all of these things are an issue.
So going back to this question about adaptogens,
adaptogens include these three categories.
I've told you the first, which are the vitamins
and micronutrients that are contained in food that
can reduce reactive oxygen species
and other aspects of cell or stress,
such as inflammatory cytokines.
What are some of those things that occur in foods?
Well, in order to answer that, let's
just think about what sorts of foods, themselves,
can act as adaptogens.
It's commonly held that the dark, leafy greens type foods,
for those of you that eat plants.
And I think the majority of people out there do eat plants.
I know that the carnivore diet and lion
diet and some other diets tend to exclude plants,
and we'll address that briefly at some point
in today's discussion.
But dark, leafy greens are known to contain
a number of compounds in the form of vitamins
and micronutrients that are very effective in reducing
reactive oxygen species and inflammatory cytokines.
So if you're somebody who's interested
in adaptogens and adaptogenic processes, reducing
stress and buffering stress, which, of course, has
its role in buffering daily stress in order
to help you sleep better to improve
cellular function for longevity sports performance,
cognitive performance, that is all good
and it makes sense why people would
be interested in adaptogens.
But remember that the two main adaptogens
that you should think to first are going
to be behaviors and nutrition.
I started with nutrition on purpose.
As I mentioned, we'll get to behaviors in a moment.
So if you're interested in adaptogens at all,
I highly recommend that you include at least two
to four servings of dark, leafy greens
and/or cruciferous vegetables per day.
I think that would be highly advantageous.
And just be aware that excessively heating dark,
leafy greens or cruciferous vegetables
can actually destroy the very nutrients
and micronutrients that act in an adaptogenic way.
That does not mean that you need to eat raw broccoli
or cauliflower, just the thought of that makes me nauseous,
it's very hard to digest.
Some people might like that or can digest it more easily
than others.
So it's perfectly fine to cook your cruciferous
vegetables and dark leafy greens,
but you don't want to overcook them.
What's overcooking and what's undercooking?
There's no strict cutoff in terms of temperature.
But basically, what the literature
says is that if you heat vegetables to the point
where the colored fluid is leaching out
of them into a broth type, into water
or whatever fluid surrounds them, well, then you
would be well off to ingest that fluid as well because it
contained in the water or the fluid that's leaching out
from the cruciferous vegetables or from the dark leafy greens,
are going to be a lot of those very adaptogenic molecules
that you're interested in the first place.
OK.
So I probably surprised some people
by starting off my answer to the question of "What
are adaptogens?
Are they worth thinking about in pursuing?
And if so, how can I get them?" by talking about food.
But I think it is important to understand that you can get
a lot of adaptogens from food.
And indeed, some of the best adaptogens
do come from dark leafy greens and cruciferous vegetables.
So I'd be remiss if I didn't mention that.
The other two categories of adaptogens
are going to be supplement-based adaptogens and then
behavioral adaptogens.
Again, here adaptogen defined as anything
that can buffer stress in a substantial or meaningful way
in order to support cellular health, organ
health, and overall daily living and functioning,
including sleep and performance in mental health.
So the second category of adaptogens
are going to be supplements.
And here, again, I just want to take a step back,
make sure that we are clear about
our operational definition about what a supplement is.
We had an episode all about how to design a rational guide
to supplementation, which included,
for example, the idea that for some people,
the optimal dosage of many supplements
is going to be zero.
And for other people, the dosage will be something else.
But to really pinpoint the key message from that episode
that I'd like to reiterate now, but a key message
from that episode that I'd like to reiterate now
is that many people think of supplements
as just vitamin supplements.
And for that reason, you'll often
hear the argument, "Oh, well, aren't supplements just
expensive urine.
Couldn't you get all of that from food?"
Aren't you just urinating out all the water-soluble vitamins
and maybe even storing excess amounts
of the fat-soluble vitamins in a way that's unhealthy
or not cost-effective?"
And so on.
When we talk about supplements, yes, it
can include vitamin supplements.
However, there are many compounds
that we would describe as supplements that are not
vitamin supplements, and that you could not obtain from food
or that you could never obtain from food
in sufficient enough qualities to have
a robust positive biological effect without consuming
an enormous number of calories or overriding your gut
mechanically.
For instance, if there were, say, a herb, and we'll
talk about such herbs in a moment,
that contained an effective adaptogen,
but you would never want to eat the plant
itself or include that herb in any kind of recipe,
well then, chances are this herb, which
we'll define in a moment, is not a vitamin supplement.
It is probably not even best thought of as a supplement,
it's best thought of as a compound
that sold over the counter, much like a prescription drug.
Although, it's not prescription.
It doesn't require a prescription to get it.
So there are a lot of things like that we
include under the umbrella of this word supplements.
And unfortunately, because of that, a lot of people
think, "Oh, you don't need supplements."
And, of course, you don't need supplements per se,
but many people do derive tremendous benefit from them.
In the context of adaptogens, there
are two or three in particular that
can be very beneficial for buffering the stress
response, especially, over short periods of time
of about two to three weeks.
So when would you use these?
Well, for instance, if you are in a particularly stressful
mode of life, either because of family or relational or school
or work demands or new kid in the house
or-- any number of different things, or you've been ill
or you're recovering from injury,
taking an adaptogen in the form of a supplement
can actually be very useful for buffering this hormone
and the general system is associated with,
called cortisol.
It's very healthy to have high levels
of cortisol early in the day, shortly after you wake up.
And then that ought to taper off toward the afternoon
and evening.
However, if cortisol is chronically
elevated throughout the day, or if that peak in cortisol
is arriving too late in the day, that
is known to be associated with mental health
and physical health issues.
Has been shown by labs at Stanford and elsewhere.
It's been shown in animal models and in humans.
Talked many times before, and I'll just remind you again.
One of the best ways to restrict that cortisol peak
to the early part of the day is to get morning sunlight
in your eyes as soon as you can.
Once the sun is up, get outside face
in the direction of the sun, even on overcast days.
Don't wear sunglasses, look at it for five to 30 minutes.
Definitely blink so you don't damage your eyes,
so on and so forth.
Why five minutes or 30 minutes?
Well, five minutes on a clear day should be sufficient,
longer would be fine.
Again, blink so that you protect your eyes.
Blink as needed.
Face in the general direction of the sun.
On days when you have a lot of overcast or it's really dark,
dense cloud cover, well, then, you'd
want to be outside longer.
And if you don't have access to sunlight for whatever reason,
then you want to do the same thing
with bright artificial lights indoors, either so-called SAD
lamp or otherwise.
That's a great way to restrict that cortisol peak
to early in the day.
But even if you're doing that, if you
have a stressful life for whatever reason,
even if you're getting that morning sunlight, which I hope
you are, you're getting your exercise,
you're trying to sleep better and more as we all
should most of the time, well, then you
may be somebody who wants to take a adaptogen
in the form of a supplement.
And the three supplements that can
be very effective in buffering cortisol
are ashwagandha, which I'll talk about first, lion's mane
and chaga.
Lion's mane and chaga are in the fungi group,
so they count as mushrooms.
They are not psychedelic mushrooms.
Let's talk about ashwagandha first.
Ashwagandha is at the top of the list
because it is indeed a very potent adaptogen.
How can I say that?
Well, there are a number of studies
now, including several excellent ones
in humans, that report that taking
two doses of 300 milligrams of ashwagandha per day
can, very dramatically, buffer cortisol.
So this is something that you would
have a near-impossible time accessing from food.
I can't imagine that, unless you're
cooking with the very sources of ashwagandha
and extracting exact amounts that you'd
be able to get this in any other form except supplement form.
So here I'm going to just briefly reference a paper
and we can provide a reference link to this, that is.
This is a paper from 2012 that's had
a lot of excellent follow-up papers that support it.
The title of the paper is A prospective randomized
double-blind placebo-controlled study of safety and efficacy
of high concentration of full spectrum
extract of ashwagandha root in reducing
stress and anxiety in adults.
And it's a really nice study.
Not a huge subject pool, but both men and women, and
has carried out for long enough that they
got to see some really interesting results.
And I think the most interesting result
is that taking 300 milligrams of ashwagandha twice a day
led to enormous--
I mean, just enormous changes in serum cortisol.
The statistical significance that they observed in the study
was really fantastic, fantastically high
statistical significance.
They saw the effects of ashwagandha on day 15,
having initiated the ashwagandha consumption on day one,
of course, day 30 and day 45.
And again, this was dramatic reductions
in stress as perceived by people.
So subjective stress and cortisol levels.
So ashwagandha is very potent at reducing cortisol.
How would you recapitulate this if you
wanted to use ashwagandha to buffer stress?
Well, a couple of key points.
I mentioned earlier that you want your cortisol peak
to come earlier in the day.
Therefore, you would not want to buffer
cortisol early in the day.
In fact, cortisol peaking early in the day
provides an anti-inflammatory immune-supporting, focus
and mood supporting effect all day long.
So I would recommend that people take
their first dose of ashwagandha anywhere from 250 to 300
milligrams.
Sometime in the early afternoon and again in the evening,
as opposed to taking a morning dose in an afternoon dose.
Also, if you're somebody who's exercising
for sake of trying to induce adaptations like hypertrophy,
the growth of muscles or strength,
or improve your endurance in any way,
muscular endurance or more traditional cardiovascular
endurance, then I recommend that you not take your ashwagandha
prior to exercise because part of the adaptation response
is triggered by increases in cortisol during exercise.
Sort of in the same way that some of the best
adaptations to exercise are reductions in blood pressure
and resting heart rate.
And those are stimulated by increases in blood pressure
and increases in heart rate during exercise.
That's just how these biological systems work.
So the takeaway is pretty simple.
If you're interested in using ashwagandha as an adaptogen,
I would restrict it to later in the day
if you can and not before exercise.
Divide it into two doses of 250 to 300 milligrams.
That's what this paper and other papers
like it seem to indicate.
And then a very important final point about ashwagandha,
which is that if you're going to take ashwagandha,
I recommend not taking it for longer than a month-and-a-half
as they did in this study.
In fact, I would suggest that you only
take ashwagandha around periods of moderate to extreme stress.
What's moderate, what's extreme is
going to depend on what you're going through.
Only how much stress and life events you can tolerate.
So if you've had trouble sleeping and that's
unusual for you.
Or, you're dealing with a very difficult life circumstances
or excessive work demand, or a new kid, as I mentioned before.
Well, then buffering stress with ashwagandha,
buffering cortisol in the afternoon and evening
can be very beneficial for you.
But then I would say after about 30 days maximum,
I would take at least two to four weeks off.
Two weeks is probably enough, but four weeks off
because you don't want to chronically buffer cortisol.
It's just not a good idea.
But that said, I think ashwagandha
is a very powerful adaptogen. I would
place at the top of the list of supplement-based adaptogens.
But keep in mind that even if you're
taking a supplement-based adaptogen,
that's no reason to abandon the nutrition and behavioral type
adaptogenic effects that you can create through eating
dark leafy greens, cruciferous vegetables,
then we'll talk about the behaviors in a moment.
The other two supplement-based adaptogens, as I mentioned,
are lion's mane mushroom and chaga.
And I get asked a lot about lion's mane and chaga for sake
of their purported roles in acting as nootropics as quote
unquote "smart drugs."
There are fewer data on the beneficial roles
of lion's mane and chaga for sake of nootropic effects--
we'll do an entire episode on nootropics at some point.
But there have been a few studies showing
that lion's made in supplementation and chaga
supplementation can improve memory,
and maybe even divergent thinking
associated with creativity and things of that sort.
Again, these are not psychedelic mushrooms.
That said, there are good data showing that 1,000 milligrams,
that is 1 gram, of lion's mane per day and/or--
I will talk about the end/or portion in a moment,
and/or chaga mushroom at 500 to 1,500 milligrams per day
can act as adaptogens in, again, reducing cortisol.
But also and mainly reducing some of the anti-inflammatory
cytokines that are known to circulate in high abundance
when you're under a lot of psychological and/or physical
stress.
Things like interleukin 6 and some related molecules.
So here's what I would recommend.
If you are interested in exploring adaptogens,
I'm a big fan, as some of you probably
know, if you heard that episode on rational guide
to supplementation.
I'm a big fan of mainly focusing on taking supplements
in single-ingredient formulations
so that you can figure out what dosages are best for you,
and so that you can toggle in and out those adaptogens as
needed.
So I, of course, am a fan of taking
certain blends and mixes, the one that we talk
about a lot on this podcast and we have been
a sponsor from the beginning, I've taken for a decade
now long before I ever had a podcast,
is Athletic Greens, which some of you might note
does contain some ashwagandha.
Although, the levels of ashwagandha
that are contained in Athletic Greens
are low enough that I don't see any issue with taking Athletic
Greens consistently, day to day, every day, because you're
not getting anywhere near that 600-milligram dosage.
But the idea is that if you were going
to take any adaptogen for sake of buffering stress
over the short term, say for a week or two weeks or a month,
and then taking that recommended time off,
I would start with ashwagandha.
And then if you feel you need something else to buffer
stress, keeping in mind, of course,
that you're doing the behavioral and the nutritional things
to buffer stress as well.
You can never abandon those, right?
Well, then I would suggest adding 1,000 milligrams
or 1,000 milligrams of chaga per day
and seeing how that further benefits your system in terms
of buffering stress.
How would you measure if your stress is being reduced?
Well, you're going to be sleeping better at night.
You're going to feel subjectively better, lower
levels of anxiety.
All the things that are measured in the types of studies
I described before.
Now, of course, there's nothing preventing you
from taking 600 milligrams of ashwagandha,
a gram of lion's mane, and a gram of chaga.
I know some people like to just kind of go
full tilt into everything.
But I am a big believer in really trying to isolate which
supplements and molecules work best for you and which ones
don't.
Do you need to cycle on and off lion's mane and chaga?
I'm not aware of any data showing that you do.
If, however, you're taking them every day,
I recommend that you cycle off them after a period of 30 days
or so.
And I want to be very clear about this,
just because I said cycle off after a period of 30 days
or so does not mean that you can't take them
for a shorter period of time.
So for instance, if you know that you're coming up
on a big week of stress, well, then you
could take ashwagandha and/or lion's mane and/or chaga
for that week or just that week or heading into that week
or in the following week and then stop.
There's no reason why you couldn't take them even just
for one day.
Although, the effects tend to be a bit cumulative, at least,
when we're talking about buffering anxiety.
In terms of buffering cortisol, that's
a very potent effect that as far as we know,
is going to take place on day one.
Again, keep that cortisol buffering effect away
from exercise.
At least, don't take it before exercise.
And try and buffer your cortisol in the afternoon and evening,
and this is assuming that you're working a conventional shift
and you're not up all night and sleeping
all day for sake of shift work.
So hopefully, that clarifies things
about what adaptogens are.
In fact, I never actually read the specific question,
but I think I've touched on a number of issues
that were related to the specific question.
And then I'll answer the last portion of the answer
to this question in a moment, as it
relates to behavioral tools that can act as adaptogens.
The question, itself, was there's
a lot of mixed information out there about adaptogens
like ashwagandha.
And I think that relates to what I said earlier, which
is that the definition of an adaptogen
has not really been cemented in various communities.
It's different in different communities,
and it's generally used as a matter of convenience
rather than really strictly defining what it is.
And hopefully, we've defined it accurately and broadly enough
today as something that buffers stress.
The second part of the question was
what does the scientific evidence say about adaptogens
and their ability to mediate body stress response?
They say quite a lot, and they say
that the stress response can be buffered substantially
by certain adaptogens.
Mainly, dark leafy greens, cruciferous vegetables,
ashwagandha, lion's mane, and chaga,
and of course, all the behavioral things
that are critical that I will list off in a moment.
And then the third portion of the question
is, is there any solid evidence that
has an effect on neurotransmitters or the HPA,
which is part of the stress modulation access?
The best evidence is that adaptogens can reduce cortisol
itself.
There is very little evidence that adaptogens can directly
modulate neurotransmitters or neuromodulators like dopamine,
serotonin, et cetera.
But by adjusting the timing and levels of cortisol,
especially in the afternoon and evening,
that is going to have indirect effects on levels
of dopamine, norepinephrine, et cetera, and serotonin.
But not direct effects.
So the general contour that makes for an ideal diurnal
schedule-- you heard of nocturnal, well,
the opposite that is diurnal, being awake during the daytime
and asleep at night.
The ideal kind of landscape of neurotransmitters
is higher levels of dopamine, norepinephrine, and epinephrine
in the early part of the day and cortisol,
so-called catecholamines, dopamine, norepinephrine,
and epinephrine.
And high levels of cortisol early in the day as
directed by sunlight, exercise, caffeine, hydration, movement,
all that stuff, being awake and busy and outside
or indoors with bright lights and moving
about in the early part of the day
and into the early afternoon, that's the best possible way
that we are aware of to try and get
those catecholamines released at the highest
levels in the early part of the day.
And then the ideal contour of a 24-hour cycle
will be in the later half of the day.
The evening and nighttime, you have higher levels
of things like serotonin the GABAergic system,
all the things that are somewhat sedative in preparing you
for sleep and lower levels of the catecholamines and cortisol
as I described before.
So to directly answer the question,
"Is there any evidence that adaptogens can
alter your neurotransmitters?"
Yes, but only indirectly.
And yet, that indirect control over neurotransmitters
is substantial and is important.
And if you do what I described, such as getting morning
sunlight and ideally, you'd get a little bit of deliberate
cold water exposure, by the way, to boost
adrenaline and norepinephrine and dopamine,
those catecholamines early in the day.
So quick one-minute cold shower, even
or a three-minute cold shower, or if you have access to an ice
bath early in the day, plus some sunlight,
doesn't matter which one you do first,
doing that early in the day is really
going to create that peak of cortisol, dopamine, epinephrine
early in the day.
I can't emphasize how beneficial all of that can be.
And exercise, if you can, early end of the day.
Some people can't exercise till later in the day.
I'd rather see people exercise later in the day
than not at all, provided it does not
disrupt their nighttime sleep, which of course, sleep
is the foundation of mental health, physical health,
and performance.
So yes, there is modulation of neurotransmitters,
but most of those are downstream of the effects on cortisol
that we've been talking about.
So we've defined nutritional adaptogens,
supplement-based adaptogens-- although, I don't really
like the word supplements anymore
unless we're talking about vitamin supplements
for reasons we talked about earlier.
And then there's the third category
of adaptogens, which are the behavioral tools that you
can use to buffer stress, which qualifies
those as an adaptogen. I think it's really important that we
always keep in mind that yes, there are supplements,
yes, there are prescription drugs out there.
In fact, there are prescription drugs
that you can get from a doctor that will potently
zero out your cortisol.
But most doctors are very reluctant to prescribe
those drugs because cortisol provides
a very important and functional role early in the day.
Behaviors are very effective at reducing cortisol.
What are the most effective behaviors to reduce cortisol?
Well, we talked about, one, to restrict cortisol
the early part of the day, which is viewing morning sunlight.
But how would you buffer cortisol in the late afternoon?
It's going to be all the things associated
with reducing stress.
For instance, 10 minutes or even--
my laboratory and other laboratories have shown
is even five minutes a day of just what
would be called mindfulness meditation, very simple.
You don't need to overcomplicate this.
You could use a great app like the Waking Up app
or another app of the sort.
Or, you can simply sit down, eyes
closed, breathe through your nose,
and just concentrate on your breathing.
Every time your mind drifts to something else,
bring it back to your breathing.
That's shown to reduce stress.
You could do a five-minute deliberate breath work
practice.
My laboratory has published some work related to that.
The breath work practice could be any number of things.
The two that I recommend the most
would be double inhale, followed by a full exhale,
and then repeat for a period of five minutes.
Known to substantially reduce anxiety, stress,
and the various physiological systems
associated with arousal.
You could also use box breathing,
inhale, hold, exhale, hold for equal durations
for a period of five minutes, will substantially
reduce stress.
I'm a big fan, as many of you know, of yoga nidra,
which involves no movement.
It involves just lying there, listening to a script.
Lots of yoga or scripts available online.
If you're not interested in the intentions and other things,
including yoga nidra, you can buffer stress
using an adaptogen like NSDR, non-sleep deep breast.
If you're interested in trying these sorts of things.
There's a NSDR protocol that's 10 minutes long.
Just put my name, Huberman, and NSDR
into the search browser on YouTube.
And Virtusan is provided in NSDR that's completely zero cost
and works very well for reducing stress.
It will also help teach your system
and teach you how to learn to fall asleep better at night.
So any of those practices, five to 10-minute breathing practice
or meditation, or a NSDR yoga nidra.
If you can do longer 20 or 30 minutes in the afternoon,
that's known to buffer cortisol substantially as well.
Any time you're encountering stress in real time,
I highly recommend a tool over and over
because it's so effective.
The fastest way we to buffer stress and calm down
is the so-called physiological sigh,
big Inhale through the nose till your lungs are empty, but then
sneak in a little bit more air by second inhale,
maximally inflate the lungs, then
a long exhale until you're lungs are empty.
One to three of those will reduce your stress
substantially.
Over time that should reduce, that is, buffer
your cortisol acting as an adaptogen.
There are a lot of things.
You can take a hot bath, you could take a hot shower,
you can listen to some pleasant music.
Anything that reduces your stress, technically,
is an adaptogen. So I hope I've thoroughly answered
your question by yours--
I mean, of course, this answer is going out to all of you.
This is a question that was asked by Justine Bevilacqua.
I hope I pronounced that correctly, Justine.
And thank you for that question.
I think there are a lot of people
interested in adaptogens.
So now, you can use nutrition such as cruciferous vegetables,
dark leafy greens.
And I should also mention, if you're not
ingesting enough calories each day, well,
then you are going to be in a mild mode of stress.
That's not to say that some people shouldn't take in fewer
calories than they burn in order to lose weight,
some people really need to do that for their health
or for whatever other reason.
But if you restrict calories too much,
you are going to increase cortisol output.
So keep that in mind.
So ingest sufficient calories for you and for your goals.
Aim to get dark leafy greens and cruciferous vegetables,
don't overcook them.
If you want to explore supplements,
the best supplements to act as adaptogens
are going to be ashwagandha, lion's mane, and chaga.
One or two or three of those-- although, if you're
going to pick one, I'd recommend ashwagandha, 600 milligrams
per day, taken in the later-half of the day.
And then there are the behavioral tools
that we just talked about now, which are anything that reduces
stress can reduce cortisol.
And in doing so, are technically adaptogens.
If you want to know more behavioral tools
and other tools for adjusting stress
and learn more about adaptogens, we
did a whole episode called Mastering Stress.
So you can look to that-- that episode also
pretty clearly defines, I like to think, what short-term,
medium-term, and long-term stress really are.
Keep in mind, stress is part of life.
Learning how to work with it, how to dance with it,
how to buffer it is terrific.
But zeroing out cortisol is not the goal.
The goal is to learn to modulate and control your cortisol,
and that's really what adaptogens are all about.
Thank you for joining for the beginning
of this ask-me-anything episode.
To hear the full episode and to hear future episodes of these
ask-me-anything sessions, plus to receive transcripts of them
and transcripts of the Huberman Lab podcast standard channel
and premium tools not released anywhere else,
please go to hubermanlab.com/premium.
Just to remind you why we launched the Huberman Lab
podcast premium channel, it's really twofold.
First of all, it's to raise support
for the standard Huberman Lab podcast channel, which,
of course, will still be continued to be released
every Monday in full length.
We are not going to change the format or anything
about the standard Huberman Lab podcast,
and to fund research in particular research done
on human beings.
So not animal models, but on human beings,
which I think we all agree is the species
that we are most interested in.
And we are going to, specifically, fund research
that is aimed toward developing further protocols
for mental health, physical health, and performance.
And those protocols will be distributed
through all channels.
Not just the premium channel, but through all channels,
Huberman Lab podcast and other media channels.
So the idea here is to give you information to your burning
questions in depth and allow you the opportunity
to support the kind of research that
provides those kinds of answers in the first place.
Now, an especially exciting feature of the premium channel
is that the Tiny Foundation has generously
offered to do a dollar-for-dollar match
on all funds raised for research through the premium channel.
So this is a terrific way that they're
going to amplify whatever funds come in through the premium
channel to further support research for science
and science-related tools, for mental health, physical health,
and performance.
If you'd like to sign up for the Human Lab premium channel,
again, there's a cost of $10 per month,
or you can pay $100 up front for the entire year.
That will give you access to all the AMA's.
You can ask questions and get answers to your questions.
And you'll, of course, get answers to all the questions
that other people ask as well.
There will also be some premium content such as transcripts
of the AMA's and various transcripts and protocols
of Huberman Lab podcast episodes,
and not found elsewhere.
And again, you'll be supporting research
for mental health, physical health, and performance.
You can sign up for the premium channel by going
to hubermanlab.com/premium.
Again, that's hubermanlab.com/premium.
And as always, thank you for your interest in science.
[MUSIC PLAYING]